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Hyperspectral Imaging for Resection Margin Assessment during Cancer Surgery.
Clin Cancer Res 2019; 25(12):3572-3580CC

Abstract

PURPOSE

Complete tumor removal during cancer surgery remains challenging due to the lack of accurate techniques for intraoperative margin assessment. This study evaluates the use of hyperspectral imaging for margin assessment by reporting its use in fresh human breast specimens.

EXPERIMENTAL DESIGN

Hyperspectral data were first acquired on tissue slices from 18 patients after gross sectioning of the resected breast specimen. This dataset, which contained over 22,000 spectra, was well correlated with histopathology and was used to develop a support vector machine classification algorithm and test the classification performance. In addition, we evaluated hyperspectral imaging in clinical practice by imaging the resection surface of six lumpectomy specimens. With the developed classification algorithm, we determined if hyperspectral imaging could detect malignancies in the resection surface.

RESULTS

The diagnostic performance of hyperspectral imaging on the tissue slices was high; invasive carcinoma, ductal carcinoma in situ, connective tissue, and adipose tissue were correctly classified as tumor or healthy tissue with accuracies of 93%, 84%, 70%, and 99%, respectively. These accuracies increased with the size of the area, consisting of one tissue type. The entire resection surface was imaged within 10 minutes, and data analysis was performed fast, without the need of an experienced operator. On the resection surface, hyperspectral imaging detected 19 of 20 malignancies that, according to the available histopathology information, were located within 2 mm of the resection surface.

CONCLUSIONS

These findings show the potential of using hyperspectral imaging for margin assessment during breast-conserving surgery to improve surgical outcome.

Authors+Show Affiliations

Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands. e.kho@nki.nl.Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands.Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Department of Pathology, Ghent University Hospital, Ghent, Belgium.Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands.Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands.Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, Amsterdam, the Netherlands.Department of Surgery, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Faculty of Science and Technology, University of Twente, Enschede, the Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30885938

Citation

Kho, Esther, et al. "Hyperspectral Imaging for Resection Margin Assessment During Cancer Surgery." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 25, no. 12, 2019, pp. 3572-3580.
Kho E, de Boer LL, Van de Vijver KK, et al. Hyperspectral Imaging for Resection Margin Assessment during Cancer Surgery. Clin Cancer Res. 2019;25(12):3572-3580.
Kho, E., de Boer, L. L., Van de Vijver, K. K., van Duijnhoven, F., Vrancken Peeters, M. T. F. D., Sterenborg, H. J. C. M., & Ruers, T. J. M. (2019). Hyperspectral Imaging for Resection Margin Assessment during Cancer Surgery. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 25(12), pp. 3572-3580. doi:10.1158/1078-0432.CCR-18-2089.
Kho E, et al. Hyperspectral Imaging for Resection Margin Assessment During Cancer Surgery. Clin Cancer Res. 2019 Jun 15;25(12):3572-3580. PubMed PMID: 30885938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperspectral Imaging for Resection Margin Assessment during Cancer Surgery. AU - Kho,Esther, AU - de Boer,Lisanne L, AU - Van de Vijver,Koen K, AU - van Duijnhoven,Frederieke, AU - Vrancken Peeters,Marie-Jeanne T F D, AU - Sterenborg,Henricus J C M, AU - Ruers,Theo J M, Y1 - 2019/03/18/ PY - 2018/07/04/received PY - 2018/10/24/revised PY - 2019/03/12/accepted PY - 2019/3/20/pubmed PY - 2019/3/20/medline PY - 2019/3/20/entrez SP - 3572 EP - 3580 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin. Cancer Res. VL - 25 IS - 12 N2 - PURPOSE: Complete tumor removal during cancer surgery remains challenging due to the lack of accurate techniques for intraoperative margin assessment. This study evaluates the use of hyperspectral imaging for margin assessment by reporting its use in fresh human breast specimens. EXPERIMENTAL DESIGN: Hyperspectral data were first acquired on tissue slices from 18 patients after gross sectioning of the resected breast specimen. This dataset, which contained over 22,000 spectra, was well correlated with histopathology and was used to develop a support vector machine classification algorithm and test the classification performance. In addition, we evaluated hyperspectral imaging in clinical practice by imaging the resection surface of six lumpectomy specimens. With the developed classification algorithm, we determined if hyperspectral imaging could detect malignancies in the resection surface. RESULTS: The diagnostic performance of hyperspectral imaging on the tissue slices was high; invasive carcinoma, ductal carcinoma in situ, connective tissue, and adipose tissue were correctly classified as tumor or healthy tissue with accuracies of 93%, 84%, 70%, and 99%, respectively. These accuracies increased with the size of the area, consisting of one tissue type. The entire resection surface was imaged within 10 minutes, and data analysis was performed fast, without the need of an experienced operator. On the resection surface, hyperspectral imaging detected 19 of 20 malignancies that, according to the available histopathology information, were located within 2 mm of the resection surface. CONCLUSIONS: These findings show the potential of using hyperspectral imaging for margin assessment during breast-conserving surgery to improve surgical outcome. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/30885938/Hyperspectral_Imaging_for_Resection_Margin_Assessment_during_Cancer_Surgery_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=30885938 DB - PRIME DP - Unbound Medicine ER -