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Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review.
Gynecol Obstet Invest. 2019; 84(6):521-547.GO

Abstract

BACKGROUND

We reviewed published cases of uterus-like mass (U-LM), endomyometriosis, polypoid adenomyoma (PA), adenomyomatous polyp, atypical PA (APA), and adenomyoma.

SEARCH METHODS

PubMed, Medline, and Scopus searches of all cases published in the databases till November 26, 2018.

RESULTS

We identified 45 case reports of U-LM in the pelvis, 10 cases of endomyometriosis, 44 cases of adenomyomatous polyp, 466 cases of APA and case series of adenomyoma and PA. Most case reports focused on histological description of removed lesions with no or very limited clinical correlates. Histological descriptions were often used interchangeably, which creates considerable confusion. It is unclear if endomyometriosis warrants inclusions as a distinct entity, since the distinction is blurred between adenomyomatous polyp and PA. The glandular epithelium in atypical polypoid adenomyoma exhibits atypia and the lesions have a tendency to recur with a risk of malignant transformation. Smooth muscle metaplasia and Müllerian fusion defects have been proposed as etiology, but it is possible that the lesions do not share a common origin.

CONCLUSION

There is need for more detailed and structured description of reported cases including clinical presentation and associated pathology.

Authors+Show Affiliations

Department of Health Sciences University of Leicester and University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom, mah6@le.ac.uk.Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.Department of Human Pathology, Catholic University of the Sacred Heart, Rome, Italy.Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Rome, Italy.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

30889596

Citation

Habiba, Marwan, et al. "Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review." Gynecologic and Obstetric Investigation, vol. 84, no. 6, 2019, pp. 521-547.
Habiba M, Brosens I, Zannoni GF, et al. Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review. Gynecol Obstet Invest. 2019;84(6):521-547.
Habiba, M., Brosens, I., Zannoni, G. F., & Benagiano, G. (2019). Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review. Gynecologic and Obstetric Investigation, 84(6), 521-547. https://doi.org/10.1159/000499019
Habiba M, et al. Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review. Gynecol Obstet Invest. 2019;84(6):521-547. PubMed PMID: 30889596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review. AU - Habiba,Marwan, AU - Brosens,Ivo, AU - Zannoni,Gian Franco, AU - Benagiano,Giuseppe, Y1 - 2019/03/19/ PY - 2018/05/24/received PY - 2019/02/19/accepted PY - 2019/3/20/pubmed PY - 2019/3/20/medline PY - 2019/3/20/entrez KW - Atypical polypoid adenomyoma KW - Adenomyoma KW - Adenomyomatous polyp KW - Adenomyosis KW - Endomyometriosis KW - Polypoid adenomyoma KW - Uterus-like-mass SP - 521 EP - 547 JF - Gynecologic and obstetric investigation JO - Gynecol. Obstet. Invest. VL - 84 IS - 6 N2 - BACKGROUND: We reviewed published cases of uterus-like mass (U-LM), endomyometriosis, polypoid adenomyoma (PA), adenomyomatous polyp, atypical PA (APA), and adenomyoma. SEARCH METHODS: PubMed, Medline, and Scopus searches of all cases published in the databases till November 26, 2018. RESULTS: We identified 45 case reports of U-LM in the pelvis, 10 cases of endomyometriosis, 44 cases of adenomyomatous polyp, 466 cases of APA and case series of adenomyoma and PA. Most case reports focused on histological description of removed lesions with no or very limited clinical correlates. Histological descriptions were often used interchangeably, which creates considerable confusion. It is unclear if endomyometriosis warrants inclusions as a distinct entity, since the distinction is blurred between adenomyomatous polyp and PA. The glandular epithelium in atypical polypoid adenomyoma exhibits atypia and the lesions have a tendency to recur with a risk of malignant transformation. Smooth muscle metaplasia and Müllerian fusion defects have been proposed as etiology, but it is possible that the lesions do not share a common origin. CONCLUSION: There is need for more detailed and structured description of reported cases including clinical presentation and associated pathology. SN - 1423-002X UR - https://www.unboundmedicine.com/medline/citation/30889596/Uncommon_Mixed_Endometrial_Myometrial_Benign_Tumors_of_the_Reproductive_Tract:_Literature_Review_ L2 - https://www.karger.com?DOI=10.1159/000499019 DB - PRIME DP - Unbound Medicine ER -