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Among the water-soluble vitamins, dietary intakes of vitamins C, B2 and folate are associated with the reduced risk of diabetes in Japanese women but not men.
Br J Nutr. 2019 06; 121(12):1357-1364.BJ

Abstract

Recent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B2 and homocysteine-lowering effects of vitamins B6, folate and B12 may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40-79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B2 and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B1, B3, B5, B6 and B12 were observed in either sex. The multivariable OR in the highest v. the lowest quartile of intakes among women were 0·61 (95 % CI 0·44, 0·94; P-trend = 0·04) for vitamin C, 0·56 (95 % CI 0·34, 0·93; P-trend = 0·03) for vitamin B2 and 0·70 (95 % CI 0·46, 0·98; P-trend = 0·03) for folate. Other than that for sex (P 0·10. In conclusion, higher dietary intakes of vitamins C, B2 and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women.

Authors+Show Affiliations

Department of Social Medicine, Public Health, Graduate School of Medicine,Osaka University,Osaka,Japan.Department of Social Medicine, Public Health, Graduate School of Medicine,Osaka University,Osaka,Japan.Department of Social Medicine, Public Health, Graduate School of Medicine,Osaka University,Osaka,Japan.Department of Public Health, Faculty of Medicine,Hokkaido University,Sapporo,Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30890201

Citation

Eshak, Ehab S., et al. "Among the Water-soluble Vitamins, Dietary Intakes of Vitamins C, B2 and Folate Are Associated With the Reduced Risk of Diabetes in Japanese Women but Not Men." The British Journal of Nutrition, vol. 121, no. 12, 2019, pp. 1357-1364.
Eshak ES, Iso H, Muraki I, et al. Among the water-soluble vitamins, dietary intakes of vitamins C, B2 and folate are associated with the reduced risk of diabetes in Japanese women but not men. Br J Nutr. 2019;121(12):1357-1364.
Eshak, E. S., Iso, H., Muraki, I., & Tamakoshi, A. (2019). Among the water-soluble vitamins, dietary intakes of vitamins C, B2 and folate are associated with the reduced risk of diabetes in Japanese women but not men. The British Journal of Nutrition, 121(12), 1357-1364. https://doi.org/10.1017/S000711451900062X
Eshak ES, et al. Among the Water-soluble Vitamins, Dietary Intakes of Vitamins C, B2 and Folate Are Associated With the Reduced Risk of Diabetes in Japanese Women but Not Men. Br J Nutr. 2019;121(12):1357-1364. PubMed PMID: 30890201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Among the water-soluble vitamins, dietary intakes of vitamins C, B2 and folate are associated with the reduced risk of diabetes in Japanese women but not men. AU - Eshak,Ehab S, AU - Iso,Hiroyasu, AU - Muraki,Isao, AU - Tamakoshi,Akiko, Y1 - 2019/03/20/ PY - 2019/3/21/pubmed PY - 2020/5/8/medline PY - 2019/3/21/entrez KW - T2DM type 2 diabetes mellitus KW - Diabetes KW - Japanese KW - Vitamin B KW - Vitamin C KW - Water-soluble vitamins SP - 1357 EP - 1364 JF - The British journal of nutrition JO - Br J Nutr VL - 121 IS - 12 N2 - Recent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B2 and homocysteine-lowering effects of vitamins B6, folate and B12 may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40-79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B2 and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B1, B3, B5, B6 and B12 were observed in either sex. The multivariable OR in the highest v. the lowest quartile of intakes among women were 0·61 (95 % CI 0·44, 0·94; P-trend = 0·04) for vitamin C, 0·56 (95 % CI 0·34, 0·93; P-trend = 0·03) for vitamin B2 and 0·70 (95 % CI 0·46, 0·98; P-trend = 0·03) for folate. Other than that for sex (P 0·10. In conclusion, higher dietary intakes of vitamins C, B2 and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/30890201/Among_the_water_soluble_vitamins_dietary_intakes_of_vitamins_C_B2_and_folate_are_associated_with_the_reduced_risk_of_diabetes_in_Japanese_women_but_not_men_ L2 - https://www.cambridge.org/core/product/identifier/S000711451900062X/type/journal_article DB - PRIME DP - Unbound Medicine ER -