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[Mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in chronic kidney disease: a network pharmacology-based study].
Nan Fang Yi Ke Da Xue Xue Bao. 2019 02 28; 39(2):227-234.NF

Abstract

OBJECTIVE

To identify the main active components in Shenbing decoction Ⅲ and their targets and explore the mechanism by which Shenbing decoction Ⅲ alleviates proteinuria in chronic kidney disease (CKD) based on network pharmacology.

METHODS

The active components of Shenbing decoction Ⅲ and their potential targets, along with the oral bioavailability and drug-like properties of each component were searched in the TCMSP database. The proteinuria-related targets were searched in the GeneCards database. The active component-target network was constructed using Cytoscape software, and the acquired information of the targets from ClueGO was used for enrichment analysis of the gene pathways.

RESULTS

A total of 102 active components were identified from Shenbing decoction Ⅲ. These active components acted on 126 targets, among which 69 were related to proteinuria. Enrichment analysis revealed fluid shear stress- and atherosclerosisrelated pathways as the highly significant pathways in proteinuria associated with CKD.

CONCLUSIONS

We preliminarily validated the prescription of Shenbing decoction Ⅲ and obtained scientific evidence that supported its use for treatment of proteinuria in CKD. The findings in this study provide a theoretical basis for further study of the mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in CKD.

Authors+Show Affiliations

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30890513

Citation

Liu, Huaxi, et al. "[Mechanism of Shenbing Decoction Ⅲ in the Treatment of Proteinuria in Chronic Kidney Disease: a Network Pharmacology-based Study]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 39, no. 2, 2019, pp. 227-234.
Liu H, Lü Z, Tian C, et al. [Mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in chronic kidney disease: a network pharmacology-based study]. Nan Fang Yi Ke Da Xue Xue Bao. 2019;39(2):227-234.
Liu, H., Lü, Z., Tian, C., Ouyang, W., Xiong, Y., You, Y., Chen, L., Deng, Y., Zhao, X., & Sun, X. (2019). [Mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in chronic kidney disease: a network pharmacology-based study]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 39(2), 227-234. https://doi.org/10.12122/j.issn.1673-4254.2019.02.16
Liu H, et al. [Mechanism of Shenbing Decoction Ⅲ in the Treatment of Proteinuria in Chronic Kidney Disease: a Network Pharmacology-based Study]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 02 28;39(2):227-234. PubMed PMID: 30890513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in chronic kidney disease: a network pharmacology-based study]. AU - Liu,Huaxi, AU - Lü,Zhihao, AU - Tian,Chunyang, AU - Ouyang,Wenkun, AU - Xiong,Yifan, AU - You,Yanting, AU - Chen,Liqian, AU - Deng,Yijian, AU - Zhao,Xiaoshan, AU - Sun,Xiaomin, PY - 2019/3/21/entrez PY - 2019/3/21/pubmed PY - 2019/4/4/medline KW - Shenbing decoction Ⅲ KW - chronic kidney disease KW - mechanism KW - network pharmacology KW - proteinuria SP - 227 EP - 234 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 39 IS - 2 N2 - OBJECTIVE: To identify the main active components in Shenbing decoction Ⅲ and their targets and explore the mechanism by which Shenbing decoction Ⅲ alleviates proteinuria in chronic kidney disease (CKD) based on network pharmacology. METHODS: The active components of Shenbing decoction Ⅲ and their potential targets, along with the oral bioavailability and drug-like properties of each component were searched in the TCMSP database. The proteinuria-related targets were searched in the GeneCards database. The active component-target network was constructed using Cytoscape software, and the acquired information of the targets from ClueGO was used for enrichment analysis of the gene pathways. RESULTS: A total of 102 active components were identified from Shenbing decoction Ⅲ. These active components acted on 126 targets, among which 69 were related to proteinuria. Enrichment analysis revealed fluid shear stress- and atherosclerosisrelated pathways as the highly significant pathways in proteinuria associated with CKD. CONCLUSIONS: We preliminarily validated the prescription of Shenbing decoction Ⅲ and obtained scientific evidence that supported its use for treatment of proteinuria in CKD. The findings in this study provide a theoretical basis for further study of the mechanism of Shenbing decoction Ⅲ in the treatment of proteinuria in CKD. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/30890513/[Mechanism_of_Shenbing_decoction_Ⅲ_in_the_treatment_of_proteinuria_in_chronic_kidney_disease:_a_network_pharmacology-based_study] L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30890513/ DB - PRIME DP - Unbound Medicine ER -