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Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in North Chinese: a cross-sectional study.
Sci Rep. 2019 03 19; 9(1):4874.SR

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese adults in 2015. 13C-urea breath tests were used to determine HP infection status. Abdominal ultrasonography was performed to diagnose NAFLD. Multivariable logistic regression was conducted to identify the association between HP infection and NAFLD. A total of 4081 individuals were included in this study; 2137 (52.36%) participants were HP-positive, and 1022 (47.82%) were diagnosed with NAFLD in HP-positive individuals. The odds ratios (OR) and 95% confidence intervals (CI) of participants with HP infection for NAFLD were 1.20 (1.06-1.36) in crude model and 1.27 (1.07-1.50) in fully adjusted model. When stratified by sex and dyslipidemia, the fully adjusted OR and 95% CI for NAFLD were 1.22 (1.10-1.80) in females and 1.44 (1.18-1.75) in subjects with dyslipidemia. There were not significant increased OR for NAFLD when stratified by age. The study indicate that HP infection is associated with NAFLD, particularly in females and patients with dyslipidemia, suggesting that HP eradication might be an alternative method for the prevention or treatment of NAFLD treatment.

Authors+Show Affiliations

Research Center for Translational Medicine, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.Department of Gastroenterology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.Department of Gastroenterology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.School of Public Health, Taishan Medical University, Tai'an, 271000, China.Department of Gastroenterology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.Department of Gastroenterology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China.Department of Urology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, 317500, Zhejiang, China. wuzb1399@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30890750

Citation

Jiang, Tian, et al. "Association Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease in North Chinese: a Cross-sectional Study." Scientific Reports, vol. 9, no. 1, 2019, p. 4874.
Jiang T, Chen X, Xia C, et al. Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in North Chinese: a cross-sectional study. Sci Rep. 2019;9(1):4874.
Jiang, T., Chen, X., Xia, C., Liu, H., Yan, H., Wang, G., & Wu, Z. (2019). Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in North Chinese: a cross-sectional study. Scientific Reports, 9(1), 4874. https://doi.org/10.1038/s41598-019-41371-2
Jiang T, et al. Association Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease in North Chinese: a Cross-sectional Study. Sci Rep. 2019 03 19;9(1):4874. PubMed PMID: 30890750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in North Chinese: a cross-sectional study. AU - Jiang,Tian, AU - Chen,Xia, AU - Xia,Chenmei, AU - Liu,Huamin, AU - Yan,Haifan, AU - Wang,Guoping, AU - Wu,Zhongbiao, Y1 - 2019/03/19/ PY - 2018/10/16/received PY - 2019/03/07/accepted PY - 2019/3/21/entrez PY - 2019/3/21/pubmed PY - 2020/10/2/medline SP - 4874 EP - 4874 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese adults in 2015. 13C-urea breath tests were used to determine HP infection status. Abdominal ultrasonography was performed to diagnose NAFLD. Multivariable logistic regression was conducted to identify the association between HP infection and NAFLD. A total of 4081 individuals were included in this study; 2137 (52.36%) participants were HP-positive, and 1022 (47.82%) were diagnosed with NAFLD in HP-positive individuals. The odds ratios (OR) and 95% confidence intervals (CI) of participants with HP infection for NAFLD were 1.20 (1.06-1.36) in crude model and 1.27 (1.07-1.50) in fully adjusted model. When stratified by sex and dyslipidemia, the fully adjusted OR and 95% CI for NAFLD were 1.22 (1.10-1.80) in females and 1.44 (1.18-1.75) in subjects with dyslipidemia. There were not significant increased OR for NAFLD when stratified by age. The study indicate that HP infection is associated with NAFLD, particularly in females and patients with dyslipidemia, suggesting that HP eradication might be an alternative method for the prevention or treatment of NAFLD treatment. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/30890750/Association_between_Helicobacter_pylori_infection_and_non_alcoholic_fatty_liver_disease_in_North_Chinese:_a_cross_sectional_study_ L2 - https://doi.org/10.1038/s41598-019-41371-2 DB - PRIME DP - Unbound Medicine ER -