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High-density lipoprotein and glycosylated hemoglobin in nondiabetic individuals.
Arch Intern Med. 1986 Aug; 146(8):1521-4.AI

Abstract

We investigated associations of high-density-lipoprotein (HDL) cholesterol, apolipoprotein A-I, and triglyceride levels with hemoglobin A1 (HbA1) and insulin levels in nondiabetic subjects (137 women and 111 men). In women, HDL cholesterol, apolipoprotein A-I, and log-triglyceride values were significantly correlated with those of HbA1 and log-fasting insulin. These univariate associations persisted when age and Quetelet's index were included as covariates in multiple regression analyses. Conversely, univariate associations of HDL cholesterol and log-triglyceride levels with Quetelet's index were diminished by the addition of insulin values to multivariate models. Insulin levels and Quetelet's index were highly correlated. Although there were weaker associations in men, apolipoprotein A-I and HbA1 values were inversely related. These data suggest that HDL cholesterol and apolipoprotein A-I levels are closely linked to glucose metabolism in nondiabetic individuals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3089186

Citation

Sosenko, J M., et al. "High-density Lipoprotein and Glycosylated Hemoglobin in Nondiabetic Individuals." Archives of Internal Medicine, vol. 146, no. 8, 1986, pp. 1521-4.
Sosenko JM, Kubrusly DB, Goldberg RB, et al. High-density lipoprotein and glycosylated hemoglobin in nondiabetic individuals. Arch Intern Med. 1986;146(8):1521-4.
Sosenko, J. M., Kubrusly, D. B., Goldberg, R. B., Fournier, A. M., Hsia, S. L., Gadia, M. T., & Skyler, J. S. (1986). High-density lipoprotein and glycosylated hemoglobin in nondiabetic individuals. Archives of Internal Medicine, 146(8), 1521-4.
Sosenko JM, et al. High-density Lipoprotein and Glycosylated Hemoglobin in Nondiabetic Individuals. Arch Intern Med. 1986;146(8):1521-4. PubMed PMID: 3089186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-density lipoprotein and glycosylated hemoglobin in nondiabetic individuals. AU - Sosenko,J M, AU - Kubrusly,D B, AU - Goldberg,R B, AU - Fournier,A M, AU - Hsia,S L, AU - Gadia,M T, AU - Skyler,J S, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 1521 EP - 4 JF - Archives of internal medicine JO - Arch Intern Med VL - 146 IS - 8 N2 - We investigated associations of high-density-lipoprotein (HDL) cholesterol, apolipoprotein A-I, and triglyceride levels with hemoglobin A1 (HbA1) and insulin levels in nondiabetic subjects (137 women and 111 men). In women, HDL cholesterol, apolipoprotein A-I, and log-triglyceride values were significantly correlated with those of HbA1 and log-fasting insulin. These univariate associations persisted when age and Quetelet's index were included as covariates in multiple regression analyses. Conversely, univariate associations of HDL cholesterol and log-triglyceride levels with Quetelet's index were diminished by the addition of insulin values to multivariate models. Insulin levels and Quetelet's index were highly correlated. Although there were weaker associations in men, apolipoprotein A-I and HbA1 values were inversely related. These data suggest that HDL cholesterol and apolipoprotein A-I levels are closely linked to glucose metabolism in nondiabetic individuals. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/3089186/High_density_lipoprotein_and_glycosylated_hemoglobin_in_nondiabetic_individuals_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/146/pg/1521 DB - PRIME DP - Unbound Medicine ER -