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Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study.
Sao Paulo Med J. 2018 Nov-Dec; 136(6):511-519.SP

Abstract

BACKGROUND

It has been suggested that the levels of some liver enzymes, and especially alanine aminotransferase (ALT), might be correlatable with cardiometabolic risk factors. We investigated the relationship between ALT concentration and cardiometabolic risk factors among children and adolescents.

DESIGN AND SETTING

This nationwide study in Iran was conducted within the framework of the fifth survey of a national surveillance program known as the Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable disease study (CASPIAN-V).

METHODS

The participants comprised 4200 students aged 7-18 years, who were recruited through multi-stage random cluster sampling in 30 provinces in Iran. Physical examinations and laboratory tests were conducted in accordance with standard protocols.

RESULTS

Overall, 3843 students (participation rate: 91.5%) completed the survey. Mean ALT levels were significantly higher in individuals with dyslipidemia, in terms of elevated total cholesterol (TC) or LDL-cholesterol or triglycerides (TG), excess weight and dyslipidemia. Some cardiometabolic risk factors were associated with higher levels of ALT, with the following odds ratio (OR) and 95% confidence interval (CI):metabolic syndrome (OR: 1.013; 95% CI: 1.001-1.025); elevated TC (OR: 1.060; 95% CI: 1.039-1.081), elevated LDL (OR: 1.031; 95% CI: 1.016-1.046), elevated TG (OR: 1.056; 95% CI: 1.040-1.072) and dyslipidemia (OR: 1.051; 95% CI: 1.034-1.068).

CONCLUSION

This large population-based study revealed that some cardiometabolic risk factors were significantly associated with ALT levels. These findings suggest that an association with fatty liver is an underlying mechanism for development of cardiometabolic risk factors.

Authors+Show Affiliations

MD. Professor, Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.PhD. Epidemiologist andAssistant Professor,Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; and Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.MD. Associate Professor, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.MD.Researcher,Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.MD. Professor, Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.MD. Researcher, Office of Health and Fitness, Ministry of Education, Tehran, Iran.MD. Pediatrician and Researcher, Bureau of Population, Family and School Health, Ministry of Health and Medical Education, Tehran, Iran.MD. Researcher, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.BSc. Researcher, Bureau of Population, Family and School Health, Ministry of Health and Medical Education, Tehran, Iran.MSc. Researcher, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.PhD. Nutritionist and Assistant Professor, Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30892481

Citation

Kelishadi, Roya, et al. "Association of Alanine Aminotransferase Concentration With Cardiometabolic Risk Factors in Children and Adolescents: the CASPIAN-V Cross-sectional Study." Sao Paulo Medical Journal = Revista Paulista De Medicina, vol. 136, no. 6, 2018, pp. 511-519.
Kelishadi R, Qorbani M, Heshmat R, et al. Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study. Sao Paulo Med J. 2018;136(6):511-519.
Kelishadi, R., Qorbani, M., Heshmat, R., Motamed-Gorji, N., Motlagh, M. E., Ziaodini, H., Taheri, M., Shafiee, G., Aminaee, T., Ahadi, Z., & Heidari-Beni, M. (2018). Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study. Sao Paulo Medical Journal = Revista Paulista De Medicina, 136(6), 511-519. https://doi.org/10.1590/1516-3180.2018.0161161118
Kelishadi R, et al. Association of Alanine Aminotransferase Concentration With Cardiometabolic Risk Factors in Children and Adolescents: the CASPIAN-V Cross-sectional Study. Sao Paulo Med J. 2018 Nov-Dec;136(6):511-519. PubMed PMID: 30892481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study. AU - Kelishadi,Roya, AU - Qorbani,Mostafa, AU - Heshmat,Ramin, AU - Motamed-Gorji,Nazgol, AU - Motlagh,Mohammad Esmaeil, AU - Ziaodini,Hasan, AU - Taheri,Majzoubeh, AU - Shafiee,Gita, AU - Aminaee,Tahereh, AU - Ahadi,Zeinab, AU - Heidari-Beni,Motahar, PY - 2018/09/22/received PY - 2018/11/16/accepted PY - 2019/3/21/entrez PY - 2019/3/21/pubmed PY - 2019/6/6/medline SP - 511 EP - 519 JF - Sao Paulo medical journal = Revista paulista de medicina JO - Sao Paulo Med J VL - 136 IS - 6 N2 - BACKGROUND: It has been suggested that the levels of some liver enzymes, and especially alanine aminotransferase (ALT), might be correlatable with cardiometabolic risk factors. We investigated the relationship between ALT concentration and cardiometabolic risk factors among children and adolescents. DESIGN AND SETTING: This nationwide study in Iran was conducted within the framework of the fifth survey of a national surveillance program known as the Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable disease study (CASPIAN-V). METHODS: The participants comprised 4200 students aged 7-18 years, who were recruited through multi-stage random cluster sampling in 30 provinces in Iran. Physical examinations and laboratory tests were conducted in accordance with standard protocols. RESULTS: Overall, 3843 students (participation rate: 91.5%) completed the survey. Mean ALT levels were significantly higher in individuals with dyslipidemia, in terms of elevated total cholesterol (TC) or LDL-cholesterol or triglycerides (TG), excess weight and dyslipidemia. Some cardiometabolic risk factors were associated with higher levels of ALT, with the following odds ratio (OR) and 95% confidence interval (CI):metabolic syndrome (OR: 1.013; 95% CI: 1.001-1.025); elevated TC (OR: 1.060; 95% CI: 1.039-1.081), elevated LDL (OR: 1.031; 95% CI: 1.016-1.046), elevated TG (OR: 1.056; 95% CI: 1.040-1.072) and dyslipidemia (OR: 1.051; 95% CI: 1.034-1.068). CONCLUSION: This large population-based study revealed that some cardiometabolic risk factors were significantly associated with ALT levels. These findings suggest that an association with fatty liver is an underlying mechanism for development of cardiometabolic risk factors. SN - 1806-9460 UR - https://www.unboundmedicine.com/medline/citation/30892481/Association_of_alanine_aminotransferase_concentration_with_cardiometabolic_risk_factors_in_children_and_adolescents:_the_CASPIAN_V_cross_sectional_study_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000600511&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -