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Host Determinants of MERS-CoV Transmission and Pathogenesis.
Viruses. 2019 03 19; 11(3)V

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen that causes respiratory infection in humans, ranging from asymptomatic to severe pneumonia. In dromedary camels, the virus only causes a mild infection but it spreads efficiently between animals. Differences in the behavior of the virus observed between individuals, as well as between humans and dromedary camels, highlight the role of host factors in MERS-CoV pathogenesis and transmission. One of these host factors, the MERS-CoV receptor dipeptidyl peptidase-4 (DPP4), may be a critical determinant because it is variably expressed in MERS-CoV-susceptible species as well as in humans. This could partially explain inter- and intraspecies differences in the tropism, pathogenesis, and transmissibility of MERS-CoV. In this review, we explore the role of DPP4 and other host factors in MERS-CoV transmission and pathogenesis-such as sialic acids, host proteases, and interferons. Further characterization of these host determinants may potentially offer novel insights to develop intervention strategies to tackle ongoing outbreaks.

Authors+Show Affiliations

Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. w.widagdo@erasmusmc.nl.Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. s.sooksawasdi@erasmusmc.nl.Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. g.hundie@erasmusmc.nl.Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. b.haagmans@erasmusmc.nl.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30893947

Citation

Widagdo, W, et al. "Host Determinants of MERS-CoV Transmission and Pathogenesis." Viruses, vol. 11, no. 3, 2019.
Widagdo W, Sooksawasdi Na Ayudhya S, Hundie GB, et al. Host Determinants of MERS-CoV Transmission and Pathogenesis. Viruses. 2019;11(3).
Widagdo, W., Sooksawasdi Na Ayudhya, S., Hundie, G. B., & Haagmans, B. L. (2019). Host Determinants of MERS-CoV Transmission and Pathogenesis. Viruses, 11(3). https://doi.org/10.3390/v11030280
Widagdo W, et al. Host Determinants of MERS-CoV Transmission and Pathogenesis. Viruses. 2019 03 19;11(3) PubMed PMID: 30893947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Host Determinants of MERS-CoV Transmission and Pathogenesis. AU - Widagdo,W, AU - Sooksawasdi Na Ayudhya,Syriam, AU - Hundie,Gadissa B, AU - Haagmans,Bart L, Y1 - 2019/03/19/ PY - 2019/03/01/received PY - 2019/03/11/revised PY - 2019/03/13/accepted PY - 2019/3/22/entrez PY - 2019/3/22/pubmed PY - 2019/12/18/medline KW - DPP4 KW - MERS-CoV KW - host factors KW - pathogenesis KW - transmission JF - Viruses JO - Viruses VL - 11 IS - 3 N2 - Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen that causes respiratory infection in humans, ranging from asymptomatic to severe pneumonia. In dromedary camels, the virus only causes a mild infection but it spreads efficiently between animals. Differences in the behavior of the virus observed between individuals, as well as between humans and dromedary camels, highlight the role of host factors in MERS-CoV pathogenesis and transmission. One of these host factors, the MERS-CoV receptor dipeptidyl peptidase-4 (DPP4), may be a critical determinant because it is variably expressed in MERS-CoV-susceptible species as well as in humans. This could partially explain inter- and intraspecies differences in the tropism, pathogenesis, and transmissibility of MERS-CoV. In this review, we explore the role of DPP4 and other host factors in MERS-CoV transmission and pathogenesis-such as sialic acids, host proteases, and interferons. Further characterization of these host determinants may potentially offer novel insights to develop intervention strategies to tackle ongoing outbreaks. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/30893947/Host_Determinants_of_MERS_CoV_Transmission_and_Pathogenesis_ L2 - https://www.mdpi.com/resolver?pii=v11030280 DB - PRIME DP - Unbound Medicine ER -