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Antibiotic resistance in drinking water systems: Occurrence, removal, and human health risks.
Sci Total Environ. 2019 Jun 15; 669:785-797.ST

Abstract

In recent years, there has been a growing interest on the occurrence of antibiotic-resistant bacteria (ARB) and antibiotic resistant genes (ARGs) in treated and untreated drinking water. ARB and ARGs pose a public health concern when they transfer antibiotic resistance (AR) to human pathogens. However, it is still unclear whether the presence of environmental ARB and ARGs in source water, drinking water treatment plants, and drinking water distribution systems has any significant impact on human exposure to pathogenic ARB. In this review, we critically examine the occurrence of AR in groundwater, surface water, and treated distributed water. This offered a new perspective on the human health threat posed by AR in drinking water and helped in crafting a strategy for monitoring AR effectively. Using existing data on removal of ARB and ARGs in drinking water treatment plants, presence and proliferation of AR in drinking water distribution systems, and mechanisms and pathways of AR transfer in drinking water treatment plants, we conclude that combining UV-irradiation with advanced oxidative processes (such as UV/chlorine, UV/H2O2, and H2O2/UV/TiO2) may enhance the removal of ARB and ARGs, while disinfection may promote horizontal gene transfer from environmental ARB to pathogens. The potential human health risks of AR were determined by examining human exposure to antibiotic resistant human pathogens and re-evaluating waterborne disease outbreaks and their links to environmental AR. We concluded that integrating disease outbreak analysis, human exposure modelling, and clinical data could provide critical information that can be used to estimate the dose-response relationships of pathogenic ARB in drinking water, which is required for accurate risk assessments.

Authors+Show Affiliations

Marine Biology Institute, Shantou University, Shantou, Guangdong Province, China.Biosystems and Environmental Engineering Research Group, Department of Soil Science and Agricultural Engineering, University of Zimbabwe, P.O. Box MP167, Mt. Pleasant, Harare, Zimbabwe. Electronic address: wgwenzi@agric.uz.ac.zw.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30897437

Citation

Sanganyado, Edmond, and Willis Gwenzi. "Antibiotic Resistance in Drinking Water Systems: Occurrence, Removal, and Human Health Risks." The Science of the Total Environment, vol. 669, 2019, pp. 785-797.
Sanganyado E, Gwenzi W. Antibiotic resistance in drinking water systems: Occurrence, removal, and human health risks. Sci Total Environ. 2019;669:785-797.
Sanganyado, E., & Gwenzi, W. (2019). Antibiotic resistance in drinking water systems: Occurrence, removal, and human health risks. The Science of the Total Environment, 669, 785-797. https://doi.org/10.1016/j.scitotenv.2019.03.162
Sanganyado E, Gwenzi W. Antibiotic Resistance in Drinking Water Systems: Occurrence, Removal, and Human Health Risks. Sci Total Environ. 2019 Jun 15;669:785-797. PubMed PMID: 30897437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic resistance in drinking water systems: Occurrence, removal, and human health risks. AU - Sanganyado,Edmond, AU - Gwenzi,Willis, Y1 - 2019/03/12/ PY - 2018/11/17/received PY - 2019/03/11/revised PY - 2019/03/11/accepted PY - 2019/3/22/pubmed PY - 2019/4/26/medline PY - 2019/3/22/entrez KW - Antibiotic resistance KW - Drinking water KW - Microbial risk assessment KW - Water treatment processes SP - 785 EP - 797 JF - The Science of the total environment JO - Sci Total Environ VL - 669 N2 - In recent years, there has been a growing interest on the occurrence of antibiotic-resistant bacteria (ARB) and antibiotic resistant genes (ARGs) in treated and untreated drinking water. ARB and ARGs pose a public health concern when they transfer antibiotic resistance (AR) to human pathogens. However, it is still unclear whether the presence of environmental ARB and ARGs in source water, drinking water treatment plants, and drinking water distribution systems has any significant impact on human exposure to pathogenic ARB. In this review, we critically examine the occurrence of AR in groundwater, surface water, and treated distributed water. This offered a new perspective on the human health threat posed by AR in drinking water and helped in crafting a strategy for monitoring AR effectively. Using existing data on removal of ARB and ARGs in drinking water treatment plants, presence and proliferation of AR in drinking water distribution systems, and mechanisms and pathways of AR transfer in drinking water treatment plants, we conclude that combining UV-irradiation with advanced oxidative processes (such as UV/chlorine, UV/H2O2, and H2O2/UV/TiO2) may enhance the removal of ARB and ARGs, while disinfection may promote horizontal gene transfer from environmental ARB to pathogens. The potential human health risks of AR were determined by examining human exposure to antibiotic resistant human pathogens and re-evaluating waterborne disease outbreaks and their links to environmental AR. We concluded that integrating disease outbreak analysis, human exposure modelling, and clinical data could provide critical information that can be used to estimate the dose-response relationships of pathogenic ARB in drinking water, which is required for accurate risk assessments. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/30897437/Antibiotic_resistance_in_drinking_water_systems:_Occurrence_removal_and_human_health_risks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(19)31144-1 DB - PRIME DP - Unbound Medicine ER -