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Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES).
Epilepsy Behav. 2019 05; 94:93-99.EB

Abstract

Few studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. For all patients, focal, multifocal, or generalized spike and wave activity occupied greater than 50% of the nonrapid eye movement (REM) sleep record. Patients were seen for follow-up EEG recording and neuropsychological testing with an average of 10 months following initiation of pulse-dose prednisone. Improvement in language or behavior was examined in relation to resolution of ESES on EEG, age at seizure onset and treatment, duration of ESES, duration of treatment, lesional versus nonlesional epilepsy, history of language or behavioral regression, seizure control at follow-up, and intelligence quotient (IQ). With the exception of a greater likelihood of patients with low IQ to demonstrate improvement in language or behavior, improvement was seen in most patients, irrespective of ESES or other factors.

Authors+Show Affiliations

Minnesota Epilepsy Group, P.A., St. Paul, Minnesota, USA. Electronic address: ahempel@mnepilepsy.net.Minnesota Epilepsy Group, P.A., St. Paul, Minnesota, USA; Children's Hospitals and Clinics of Minnesota, St. Paul, Minnesota, USA.Minnesota Epilepsy Group, P.A., St. Paul, Minnesota, USA; Children's Hospitals and Clinics of Minnesota, St. Paul, Minnesota, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30897536

Citation

Hempel, Ann, et al. "Language and Behavioral Outcomes of Treatment With Pulse-dose Prednisone for Electrical Status Epilepticus in Sleep (ESES)." Epilepsy & Behavior : E&B, vol. 94, 2019, pp. 93-99.
Hempel A, Frost M, Agarwal N. Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES). Epilepsy Behav. 2019;94:93-99.
Hempel, A., Frost, M., & Agarwal, N. (2019). Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES). Epilepsy & Behavior : E&B, 94, 93-99. https://doi.org/10.1016/j.yebeh.2019.02.016
Hempel A, Frost M, Agarwal N. Language and Behavioral Outcomes of Treatment With Pulse-dose Prednisone for Electrical Status Epilepticus in Sleep (ESES). Epilepsy Behav. 2019;94:93-99. PubMed PMID: 30897536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES). AU - Hempel,Ann, AU - Frost,Michael, AU - Agarwal,Nitin, Y1 - 2019/03/18/ PY - 2018/12/04/received PY - 2019/02/17/revised PY - 2019/02/17/accepted PY - 2019/3/22/pubmed PY - 2020/7/3/medline PY - 2019/3/22/entrez KW - Behavioral disorders KW - Cognition KW - Electrical status epilepticus in sleep KW - Neuropsychology KW - Prednisone KW - Steroids SP - 93 EP - 99 JF - Epilepsy & behavior : E&B JO - Epilepsy Behav VL - 94 N2 - Few studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. For all patients, focal, multifocal, or generalized spike and wave activity occupied greater than 50% of the nonrapid eye movement (REM) sleep record. Patients were seen for follow-up EEG recording and neuropsychological testing with an average of 10 months following initiation of pulse-dose prednisone. Improvement in language or behavior was examined in relation to resolution of ESES on EEG, age at seizure onset and treatment, duration of ESES, duration of treatment, lesional versus nonlesional epilepsy, history of language or behavioral regression, seizure control at follow-up, and intelligence quotient (IQ). With the exception of a greater likelihood of patients with low IQ to demonstrate improvement in language or behavior, improvement was seen in most patients, irrespective of ESES or other factors. SN - 1525-5069 UR - https://www.unboundmedicine.com/medline/citation/30897536/Language_and_behavioral_outcomes_of_treatment_with_pulse_dose_prednisone_for_electrical_status_epilepticus_in_sleep__ESES__ DB - PRIME DP - Unbound Medicine ER -