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Anti-inflammatory effect and the effect on acute pharyngitis rats model of compound Lobelia oral liquid.
Saudi J Biol Sci 2019; 26(3):577-581SJ

Abstract

Objective

Observe anti-inflammatory effect and the effect on acute pharyngitis rats model induced by ammonia water of compound Lobelia oral liquid, providing experimental basis for its clinical use.

Methods

Use egg white establish foot swelling rats model and use carboxymethyl cellulose establish white blood cell migration rats model. Then observe the anti-inflammatory effect of compound Lobelia oral liquid. Use 15% ammonia spray at pharyngeal establish acute pharyngitis rats model, Visual observation and conduct grading of pharyngeal tissue stimulation in rats, measure the levels of TNF-α and IL-6 in serum. Pharyngeal tissue was taken to observe the morphological changes.

Result

All dose groups of compound Lobelia oral liquid can reduce the rate of foot swelling of rats at all time points (P < 0.01 or P < 0.05), and significantly reduce the number of white blood cells of rats (P < 0.01); And improve the local hyperemia degree, reduce secretion, reduce local swelling of pharyngeal tissue, reduce the serum TNF-α and IL-6 levels of acute pharyngitis rats with different degrees (P < 0.01 or P < 0.05).

Conclusion

Compound Lobelia oral liquid has a good anti-inflammatory effect on foot swelling and white blood cell migration rats model, as well as significant improvement effect on acute pharyngitis rats model.

Authors+Show Affiliations

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30899174

Citation

Liu, Baosong, et al. "Anti-inflammatory Effect and the Effect On Acute Pharyngitis Rats Model of Compound Lobelia Oral Liquid." Saudi Journal of Biological Sciences, vol. 26, no. 3, 2019, pp. 577-581.
Liu B, Bai M, Peng M, et al. Anti-inflammatory effect and the effect on acute pharyngitis rats model of compound Lobelia oral liquid. Saudi J Biol Sci. 2019;26(3):577-581.
Liu, B., Bai, M., Peng, M., & Miao, M. (2019). Anti-inflammatory effect and the effect on acute pharyngitis rats model of compound Lobelia oral liquid. Saudi Journal of Biological Sciences, 26(3), pp. 577-581. doi:10.1016/j.sjbs.2018.11.018.
Liu B, et al. Anti-inflammatory Effect and the Effect On Acute Pharyngitis Rats Model of Compound Lobelia Oral Liquid. Saudi J Biol Sci. 2019;26(3):577-581. PubMed PMID: 30899174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory effect and the effect on acute pharyngitis rats model of compound Lobelia oral liquid. AU - Liu,Baosong, AU - Bai,Ming, AU - Peng,Mengfan, AU - Miao,Mingsan, Y1 - 2018/11/26/ PY - 2018/08/13/received PY - 2018/11/24/revised PY - 2018/11/25/accepted PY - 2019/3/23/entrez PY - 2019/3/23/pubmed PY - 2019/3/23/medline KW - Acute pharyngitis KW - Anti-inflammatory effect KW - Foot swelling KW - Pathological changes KW - White blood cell migration SP - 577 EP - 581 JF - Saudi journal of biological sciences JO - Saudi J Biol Sci VL - 26 IS - 3 N2 - Objective: Observe anti-inflammatory effect and the effect on acute pharyngitis rats model induced by ammonia water of compound Lobelia oral liquid, providing experimental basis for its clinical use. Methods: Use egg white establish foot swelling rats model and use carboxymethyl cellulose establish white blood cell migration rats model. Then observe the anti-inflammatory effect of compound Lobelia oral liquid. Use 15% ammonia spray at pharyngeal establish acute pharyngitis rats model, Visual observation and conduct grading of pharyngeal tissue stimulation in rats, measure the levels of TNF-α and IL-6 in serum. Pharyngeal tissue was taken to observe the morphological changes. Result: All dose groups of compound Lobelia oral liquid can reduce the rate of foot swelling of rats at all time points (P < 0.01 or P < 0.05), and significantly reduce the number of white blood cells of rats (P < 0.01); And improve the local hyperemia degree, reduce secretion, reduce local swelling of pharyngeal tissue, reduce the serum TNF-α and IL-6 levels of acute pharyngitis rats with different degrees (P < 0.01 or P < 0.05). Conclusion: Compound Lobelia oral liquid has a good anti-inflammatory effect on foot swelling and white blood cell migration rats model, as well as significant improvement effect on acute pharyngitis rats model. SN - 1319-562X UR - https://www.unboundmedicine.com/medline/citation/30899174/Anti-inflammatory_effect_and_the_effect_on_acute_pharyngitis_rats_model_of_compound_Lobelia_oral_liquid L2 - https://linkinghub.elsevier.com/retrieve/pii/S1319-562X(18)30296-1 DB - PRIME DP - Unbound Medicine ER -