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Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo.
J Curr Ophthalmol 2019; 31(1):102-105JC

Abstract

Purpose

To report an accelerated course of visual recovery in a case of Leber's hereditary optic neuropathy (LHON) following treatment with idebenone and hormone replacement therapy (HRT). We hereby demonstrate the clinical utility of estrogen's protective role in LHON in vivo.

Methods

We present a case of LHON in a menopausal woman carrying the 10197 mitochondrial DNA (mtDNA) mutation, who experienced loss of vision shortly after discontinuing her estrogen replacement regimen. Functional visual outcomes are reported following treatment with idebenone and HRT.

Results

The patient exhibited an accelerated course of visual recovery, experiencing improvement in vision as early as one month and complete reversal of vision loss by eight months post-therapy.

Conclusion

Idebenone treatment combined with HRT may have a synergistic effect in enhancing cellular bioenergetics and may explain the patient's accelerated visual improvement.

Authors+Show Affiliations

University of Udine, Department of Ophthalmology, Udine, Italy. Doheny Eye Institute, Los Angeles, CA, USA.Doheny Eye Institute, Los Angeles, CA, USA. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.Doheny Eye Institute, Los Angeles, CA, USA. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.Doheny Eye Institute, Los Angeles, CA, USA. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

30899856

Citation

Fantini, Michele, et al. "Hormone Replacement Therapy in Leber's Hereditary Optic Neuropathy: Accelerated Visual Recovery in Vivo." Journal of Current Ophthalmology, vol. 31, no. 1, 2019, pp. 102-105.
Fantini M, Asanad S, Karanjia R, et al. Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo. J Curr Ophthalmol. 2019;31(1):102-105.
Fantini, M., Asanad, S., Karanjia, R., & Sadun, A. (2019). Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo. Journal of Current Ophthalmology, 31(1), pp. 102-105. doi:10.1016/j.joco.2018.10.003.
Fantini M, et al. Hormone Replacement Therapy in Leber's Hereditary Optic Neuropathy: Accelerated Visual Recovery in Vivo. J Curr Ophthalmol. 2019;31(1):102-105. PubMed PMID: 30899856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo. AU - Fantini,Michele, AU - Asanad,Samuel, AU - Karanjia,Rustum, AU - Sadun,Alfredo, Y1 - 2018/11/03/ PY - 2018/09/14/received PY - 2018/10/02/revised PY - 2018/10/05/accepted PY - 2019/3/23/entrez PY - 2019/3/23/pubmed PY - 2019/3/23/medline KW - Accelerated visual improvement KW - Hormone replacement therapy KW - Leber's hereditary optic neuropathy KW - Mitochondrial disease SP - 102 EP - 105 JF - Journal of current ophthalmology JO - J Curr Ophthalmol VL - 31 IS - 1 N2 - Purpose: To report an accelerated course of visual recovery in a case of Leber's hereditary optic neuropathy (LHON) following treatment with idebenone and hormone replacement therapy (HRT). We hereby demonstrate the clinical utility of estrogen's protective role in LHON in vivo. Methods: We present a case of LHON in a menopausal woman carrying the 10197 mitochondrial DNA (mtDNA) mutation, who experienced loss of vision shortly after discontinuing her estrogen replacement regimen. Functional visual outcomes are reported following treatment with idebenone and HRT. Results: The patient exhibited an accelerated course of visual recovery, experiencing improvement in vision as early as one month and complete reversal of vision loss by eight months post-therapy. Conclusion: Idebenone treatment combined with HRT may have a synergistic effect in enhancing cellular bioenergetics and may explain the patient's accelerated visual improvement. SN - 2452-2325 UR - https://www.unboundmedicine.com/medline/citation/30899856/Hormone_replacement_therapy_in_Leber's_hereditary_optic_neuropathy:_Accelerated_visual_recovery_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2452-2325(18)30211-7 DB - PRIME DP - Unbound Medicine ER -