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Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Clin Transplant. 2019 09; 33(9):e13546.CT

Abstract

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tissue and blood protozoal infections in the pre- and post-transplant period. Significant new developments in the field have made it necessary to divide the previous single guideline published in 2013 into two sections, with the intestinal parasites separated from this guideline devoted to tissue and blood protozoa. The current update reflects the increased focus on donor screening and risk-based recipient monitoring for parasitic infections. Increased donor testing has led to new recommendations for recipient management of Toxoplasma gondii and Trypanosoma cruzi. Molecular diagnostics have impacted the field, with access to rapid diagnostic testing for malaria and polymerase chain reaction testing for Leishmania. Changes in Babesia treatment regimens in the immunocompromised host are outlined. The risk of donor transmission of free-living amebae infection is reviewed. Changing immigration patterns and the expansion of transplant medicine in developing countries has contributed to the recognition of parasitic infections as an important threat to transplant outcomes. Medications such as benznidazole and miltefosine are now available to US prescribers as access to treatment of tissue and blood protozoa is increasingly prioritized.

Authors+Show Affiliations

Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30900295

Citation

La Hoz, Ricardo M., et al. "Tissue and Blood Protozoa Including Toxoplasmosis, Chagas Disease, Leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in Solid Organ Transplant Recipients- Guidelines From the American Society of Transplantation Infectious Diseases Community of Practice." Clinical Transplantation, vol. 33, no. 9, 2019, pp. e13546.
La Hoz RM, Morris MI, Infectious Diseases Community of Practice of the American Society of Transplantation. Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13546.
La Hoz, R. M., & Morris, M. I. (2019). Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation, 33(9), e13546. https://doi.org/10.1111/ctr.13546
La Hoz RM, Morris MI, Infectious Diseases Community of Practice of the American Society of Transplantation. Tissue and Blood Protozoa Including Toxoplasmosis, Chagas Disease, Leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in Solid Organ Transplant Recipients- Guidelines From the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13546. PubMed PMID: 30900295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. AU - La Hoz,Ricardo M, AU - Morris,Michele I, AU - ,, Y1 - 2019/04/29/ PY - 2019/02/02/received PY - 2019/02/27/accepted PY - 2019/3/23/pubmed PY - 2020/10/2/medline PY - 2019/3/23/entrez KW - Acanthamoeba KW - Babesia KW - Balamuthia KW - Naegleria KW - Toxoplasma gondii KW - Trypanosoma cruzi KW - donor-derived KW - leishmaniasis KW - malaria KW - parasites KW - transplant SP - e13546 EP - e13546 JF - Clinical transplantation JO - Clin Transplant VL - 33 IS - 9 N2 - These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of tissue and blood protozoal infections in the pre- and post-transplant period. Significant new developments in the field have made it necessary to divide the previous single guideline published in 2013 into two sections, with the intestinal parasites separated from this guideline devoted to tissue and blood protozoa. The current update reflects the increased focus on donor screening and risk-based recipient monitoring for parasitic infections. Increased donor testing has led to new recommendations for recipient management of Toxoplasma gondii and Trypanosoma cruzi. Molecular diagnostics have impacted the field, with access to rapid diagnostic testing for malaria and polymerase chain reaction testing for Leishmania. Changes in Babesia treatment regimens in the immunocompromised host are outlined. The risk of donor transmission of free-living amebae infection is reviewed. Changing immigration patterns and the expansion of transplant medicine in developing countries has contributed to the recognition of parasitic infections as an important threat to transplant outcomes. Medications such as benznidazole and miltefosine are now available to US prescribers as access to treatment of tissue and blood protozoa is increasingly prioritized. SN - 1399-0012 UR - https://www.unboundmedicine.com/medline/citation/30900295/Tissue_and_blood_protozoa_including_toxoplasmosis_Chagas_disease_leishmaniasis_Babesia_Acanthamoeba_Balamuthia_and_Naegleria_in_solid_organ_transplant_recipients__Guidelines_from_the_American_Society_of_Transplantation_Infectious_Diseases_Community_of_Practice_ L2 - https://doi.org/10.1111/ctr.13546 DB - PRIME DP - Unbound Medicine ER -