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The independent association of non-alcoholic fatty liver disease with lower urinary tract symptoms/benign prostatic hyperplasia and erectile function scores.
BJU Int. 2019 08; 124(2):329-335.BI

Abstract

OBJECTIVES

To evaluate the association between non-alcoholic fatty liver disease (NAFLD) and lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and erectile function.

PATIENTS AND METHODS

In all, 356 men diagnosed with LUTS/BPH were evaluated retrospectively between January 2016 and March 2018. Anthropometric and laboratory data were collected. According to the liver echogenicity degree, patients were divided into four NAFLD groups: Grade 0 was considered as normal with no NAFLD, whilst Grades 1-3 NAFLD had increasing fat deposits. LUTS symptoms, prostate-specific antigen (PSA) levels, prostate volumes (PVs), and five-item version of the International Index of Erectile Function (IIEF-5) scores were compared statistically between the NAFLD grades.

RESULTS

PSA levels did not differ between the groups. The International Prostate Symptom Score (IPSS), PV and post-voided residual urine volume (PVR) were significantly greater in men with higher NAFLD grades. Conversely, the maximum urinary flow rate (Qmax) and IIEF-5 score were lower in men with higher NAFLD grades. The NAFLD grade, rather than being metabolic syndrome (MetS) positive, affected prostate parameters and IIEF-5 scores. NAFLD grade correlated positively with IPSS, PV and PVR, whereas there was a negative correlation with Qmax and IIEF-5 score. Age and NAFLD were independent predictors of IPSS, PV, Qmax , and PVR on multivariate analysis.

CONCLUSION

We found that NAFLD was an independent predictive factor for IPSS, PV, Qmax , PVR and IIEF-5 score. MetS was only a significant predictive factor for IIEF-5 score, thus NAFLD may identify patients at high risk of LUTS better than MetS.

Authors+Show Affiliations

Department of Urology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.Department of Urology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30900792

Citation

Eren, Huseyin, and Mustafa O. Horsanali. "The Independent Association of Non-alcoholic Fatty Liver Disease With Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia and Erectile Function Scores." BJU International, vol. 124, no. 2, 2019, pp. 329-335.
Eren H, Horsanali MO. The independent association of non-alcoholic fatty liver disease with lower urinary tract symptoms/benign prostatic hyperplasia and erectile function scores. BJU Int. 2019;124(2):329-335.
Eren, H., & Horsanali, M. O. (2019). The independent association of non-alcoholic fatty liver disease with lower urinary tract symptoms/benign prostatic hyperplasia and erectile function scores. BJU International, 124(2), 329-335. https://doi.org/10.1111/bju.14753
Eren H, Horsanali MO. The Independent Association of Non-alcoholic Fatty Liver Disease With Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia and Erectile Function Scores. BJU Int. 2019;124(2):329-335. PubMed PMID: 30900792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The independent association of non-alcoholic fatty liver disease with lower urinary tract symptoms/benign prostatic hyperplasia and erectile function scores. AU - Eren,Huseyin, AU - Horsanali,Mustafa O, Y1 - 2019/04/18/ PY - 2019/3/23/pubmed PY - 2020/3/14/medline PY - 2019/3/23/entrez KW - #LUTS KW - #UroBPH KW - benign prostate hyperplasia KW - erectile dysfunction KW - lower urinary tract symptoms KW - metabolic syndrome KW - non-alcoholic fatty liver disease SP - 329 EP - 335 JF - BJU international JO - BJU Int VL - 124 IS - 2 N2 - OBJECTIVES: To evaluate the association between non-alcoholic fatty liver disease (NAFLD) and lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and erectile function. PATIENTS AND METHODS: In all, 356 men diagnosed with LUTS/BPH were evaluated retrospectively between January 2016 and March 2018. Anthropometric and laboratory data were collected. According to the liver echogenicity degree, patients were divided into four NAFLD groups: Grade 0 was considered as normal with no NAFLD, whilst Grades 1-3 NAFLD had increasing fat deposits. LUTS symptoms, prostate-specific antigen (PSA) levels, prostate volumes (PVs), and five-item version of the International Index of Erectile Function (IIEF-5) scores were compared statistically between the NAFLD grades. RESULTS: PSA levels did not differ between the groups. The International Prostate Symptom Score (IPSS), PV and post-voided residual urine volume (PVR) were significantly greater in men with higher NAFLD grades. Conversely, the maximum urinary flow rate (Qmax) and IIEF-5 score were lower in men with higher NAFLD grades. The NAFLD grade, rather than being metabolic syndrome (MetS) positive, affected prostate parameters and IIEF-5 scores. NAFLD grade correlated positively with IPSS, PV and PVR, whereas there was a negative correlation with Qmax and IIEF-5 score. Age and NAFLD were independent predictors of IPSS, PV, Qmax , and PVR on multivariate analysis. CONCLUSION: We found that NAFLD was an independent predictive factor for IPSS, PV, Qmax , PVR and IIEF-5 score. MetS was only a significant predictive factor for IIEF-5 score, thus NAFLD may identify patients at high risk of LUTS better than MetS. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/30900792/The_independent_association_of_non_alcoholic_fatty_liver_disease_with_lower_urinary_tract_symptoms/benign_prostatic_hyperplasia_and_erectile_function_scores_ L2 - https://doi.org/10.1111/bju.14753 DB - PRIME DP - Unbound Medicine ER -