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Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015.
Emerg Infect Dis. 2019 06; 25(6):1161-1168.EI

Abstract

The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several "superspreading" events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak.

Authors

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Pub Type(s)

Historical Article
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30900977

Citation

Kim, Yeon-Sook, et al. "Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015." Emerging Infectious Diseases, vol. 25, no. 6, 2019, pp. 1161-1168.
Kim YS, Aigerim A, Park U, et al. Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015. Emerg Infect Dis. 2019;25(6):1161-1168.
Kim, Y. S., Aigerim, A., Park, U., Kim, Y., Rhee, J. Y., Choi, J. P., Park, W. B., Park, S. W., Kim, Y., Lim, D. G., Inn, K. S., Hwang, E. S., Choi, M. S., Shin, H. S., & Cho, N. H. (2019). Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015. Emerging Infectious Diseases, 25(6), 1161-1168. https://doi.org/10.3201/eid2506.181722
Kim YS, et al. Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015. Emerg Infect Dis. 2019;25(6):1161-1168. PubMed PMID: 30900977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sequential Emergence and Wide Spread of Neutralization Escape Middle East Respiratory Syndrome Coronavirus Mutants, South Korea, 2015. AU - Kim,Yeon-Sook, AU - Aigerim,Abdimadiyeva, AU - Park,Uni, AU - Kim,Yuri, AU - Rhee,Ji-Young, AU - Choi,Jae-Phil, AU - Park,Wan Beom, AU - Park,Sang Won, AU - Kim,Yeonjae, AU - Lim,Dong-Gyun, AU - Inn,Kyung-Soo, AU - Hwang,Eung-Soo, AU - Choi,Myung-Sik, AU - Shin,Hyoung-Shik, AU - Cho,Nam-Hyuk, Y1 - 2019/06/17/ PY - 2019/3/23/pubmed PY - 2019/12/24/medline PY - 2019/3/23/entrez KW - MERS-CoV KW - Middle East respiratory syndrome coronavirus KW - South Korea KW - antibody neutralization KW - respiratory infections KW - sequential emergence KW - spike KW - superspreading KW - viruses KW - zoonoses SP - 1161 EP - 1168 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 25 IS - 6 N2 - The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several "superspreading" events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/30900977/Sequential_Emergence_and_Wide_Spread_of_Neutralization_Escape_Middle_East_Respiratory_Syndrome_Coronavirus_Mutants_South_Korea_2015_ L2 - https://doi.org/10.3201/eid2506.181722 DB - PRIME DP - Unbound Medicine ER -