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Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes.
Invest Ophthalmol Vis Sci 2019; 60(4):1096-1104IO

Abstract

Purpose

To evaluate the 2-year changes in myopic maculopathy and its associations in highly myopic eyes.

Methods

This was a longitudinal, observational cohort study involving 657 Chinese participants with bilateral high myopia (≤ -6.00 diopters spherical power), who were followed for 2 years. The worst eye of each participant was considered for the analysis. Myopic maculopathy was graded based on fundus photographs, using the International Photographic Classification and Grading System for Myopic Maculopathy.

Results

The mean baseline age was 21.6 ± 12.2 years (range, 6.8-69.7 years). Myopic maculopathy progressed in 97 (14.8%) of 657 eyes, of which 24 eyes progressed to a higher category of myopic maculopathy, including from no maculopathy to tessellated fundus in 17 eyes, from tessellated fundus to diffuse atrophy in 6 eyes, and from diffuse to patchy atrophy in 1 eye. Among 122 lesion changes identified, the most common changes were enlargement of diffuse atrophy (n = 50, 41.0%), appearance of lacquer cracks (n = 28, 23.0%), enlargement of patchy atrophy (n = 10, 8.2%) and development of additional lacquer cracks (n = 7, 5.8%). In addition, we identified 1 eye with enlargement of a Fuch's spot, and 1 eye with active choroidal neovascularization. In multiple logistic regression analysis, myopic maculopathy progression was associated with older age, longer axial length, greater change in myopic spherical equivalent and more severe myopic maculopathy at baseline.

Conclusions

Myopic maculopathy progressed in approximately 15% of highly myopic eyes over a 2-year period. Further studies with longer follow up periods are required to confirm identified risk factors for progression.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China. New England College of Optometry, Boston, Massachusetts, United States.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China. Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.Brien Holden Vision Institute, Sydney, New South Wales, Australia.Brien Holden Vision Institute, Sydney, New South Wales, Australia.Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China. Centre for Eye Research Australia, Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30901386

Citation

Li, Zhixi, et al. "Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes." Investigative Ophthalmology & Visual Science, vol. 60, no. 4, 2019, pp. 1096-1104.
Li Z, Liu R, Xiao O, et al. Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes. Invest Ophthalmol Vis Sci. 2019;60(4):1096-1104.
Li, Z., Liu, R., Xiao, O., Guo, X., Wang, D., Zhang, J., ... He, M. (2019). Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes. Investigative Ophthalmology & Visual Science, 60(4), pp. 1096-1104. doi:10.1167/iovs.18-25800.
Li Z, et al. Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes. Invest Ophthalmol Vis Sci. 2019 03 1;60(4):1096-1104. PubMed PMID: 30901386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes. AU - Li,Zhixi, AU - Liu,Ran, AU - Xiao,Ou, AU - Guo,Xinxing, AU - Wang,Decai, AU - Zhang,Jian, AU - Ha,Jason James, AU - Lee,Jonathan Tak Loong, AU - Lee,Peiying, AU - Jong,Monica, AU - Sankaridurg,Padmaja, AU - Ohno-Matsui,Kyoko, AU - He,Mingguang, PY - 2019/3/23/entrez PY - 2019/3/23/pubmed PY - 2019/8/24/medline SP - 1096 EP - 1104 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 60 IS - 4 N2 - Purpose: To evaluate the 2-year changes in myopic maculopathy and its associations in highly myopic eyes. Methods: This was a longitudinal, observational cohort study involving 657 Chinese participants with bilateral high myopia (≤ -6.00 diopters spherical power), who were followed for 2 years. The worst eye of each participant was considered for the analysis. Myopic maculopathy was graded based on fundus photographs, using the International Photographic Classification and Grading System for Myopic Maculopathy. Results: The mean baseline age was 21.6 ± 12.2 years (range, 6.8-69.7 years). Myopic maculopathy progressed in 97 (14.8%) of 657 eyes, of which 24 eyes progressed to a higher category of myopic maculopathy, including from no maculopathy to tessellated fundus in 17 eyes, from tessellated fundus to diffuse atrophy in 6 eyes, and from diffuse to patchy atrophy in 1 eye. Among 122 lesion changes identified, the most common changes were enlargement of diffuse atrophy (n = 50, 41.0%), appearance of lacquer cracks (n = 28, 23.0%), enlargement of patchy atrophy (n = 10, 8.2%) and development of additional lacquer cracks (n = 7, 5.8%). In addition, we identified 1 eye with enlargement of a Fuch's spot, and 1 eye with active choroidal neovascularization. In multiple logistic regression analysis, myopic maculopathy progression was associated with older age, longer axial length, greater change in myopic spherical equivalent and more severe myopic maculopathy at baseline. Conclusions: Myopic maculopathy progressed in approximately 15% of highly myopic eyes over a 2-year period. Further studies with longer follow up periods are required to confirm identified risk factors for progression. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/30901386/Progression_of_Myopic_Maculopathy_in_Highly_Myopic_Chinese_Eyes_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.18-25800 DB - PRIME DP - Unbound Medicine ER -