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Morphofunctional status of cardio-vascular system of rats with congenital hypothyreosis.
Wiad Lek 2019; 72(2):229-233WL

Abstract

OBJECTIVE

Introduction: There is an increasing number of cases of congenital hypothyroidism. One of the most common complications of hypothyroidism is damage to the cardiovascular system, which in 30-50% of patients leads to the development of arterial hypertension. The aim: studying the features of the ultrastructure of myocardial capillaries in mature rats with hypothyroidism.

PATIENTS AND METHODS

Materials and methods: Experiments were conducted on 40Wistar line rats with congenital hypothyroidism: juvenile young (45-day) and sexually mature (100-day) rats, as well as intact animals of the corresponding age. While extracted from the experiment rats of all experimental groups had their arterial pressure measured using a plethysmograph while the development of hypothyroidism was controlled by the immune-enzymatic method. Electron microscopic examination of the left ventricular myocardium and morphometric study of volumetric and quantitative densities, cross-section area, and form factor of micropinocytotic vesicles were conducted.

RESULTS

Results: In the sexually mature rats with congenital hypothyroidism the quantitative density of the capillaries in the myocardium decreases. Activation of transcytosis is accompanied by significant violations of vesiculation. Some of the endothelial cells of experimental animals contain a moderate amount of transport vesicles, while others are overfilled with these structures and desquamate into the lumen. In older rats with congenital hypothyroidism there is a further dilution of capillaries, the development of hypoxic state in them, mucinous edema of interstitial space, decrease of biosynthetic and transport processes activity.

CONCLUSION

Conclusions: In young (45-day) rats with congenital hypothyroidism the direction and expressiveness of compensatory processes is to enhance the transcytosis processes. Dystrophicdestructive changes are manifested by apoptosis in some endothelial cells, decrease in the number of biosynthetic organelles, lysis and edema of their cytoplasm. In sexually mature (100-day) rats with congenital hypothyroidism destructively-dystrophic processes in the blood capillaries of the myocardium are approximately balanced with compensatory-adaptive.

Authors+Show Affiliations

Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine.Department of Fundamental Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.Department of Human Anatomy, Bogomolets National Medical University, Kyiv, Ukraine.Department of Human Anatomy, Bogomolets National Medical University, Kyiv, Ukraine.Department of Human Anatomy, Bogomolets National Medical University, Kyiv, Ukraine.Department of Human Anatomy, Bogomolets National Medical University, Kyiv, Ukraine, Department of Fundamental Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine, Department of Fundamental Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30903778

Citation

Chuhray, Svitlana M., et al. "Morphofunctional Status of Cardio-vascular System of Rats With Congenital Hypothyreosis." Wiadomosci Lekarskie (Warsaw, Poland : 1960), vol. 72, no. 2, 2019, pp. 229-233.
Chuhray SM, Lavrynenko VE, Kaminsky RF, et al. Morphofunctional status of cardio-vascular system of rats with congenital hypothyreosis. Wiad Lek. 2019;72(2):229-233.
Chuhray, S. M., Lavrynenko, V. E., Kaminsky, R. F., Dzevulska, I. V., Malikov, O. V., Kovalchuk, O. I., & Sokurenko, L. M. (2019). Morphofunctional status of cardio-vascular system of rats with congenital hypothyreosis. Wiadomosci Lekarskie (Warsaw, Poland : 1960), 72(2), pp. 229-233.
Chuhray SM, et al. Morphofunctional Status of Cardio-vascular System of Rats With Congenital Hypothyreosis. Wiad Lek. 2019;72(2):229-233. PubMed PMID: 30903778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphofunctional status of cardio-vascular system of rats with congenital hypothyreosis. AU - Chuhray,Svitlana M, AU - Lavrynenko,Viktoria E, AU - Kaminsky,Rostyslav F, AU - Dzevulska,Iryna V, AU - Malikov,Olexandr V, AU - Kovalchuk,Olexandr I, AU - Sokurenko,Liudmyla M, PY - 2019/3/24/entrez PY - 2019/3/25/pubmed PY - 2019/8/29/medline KW - congenital hypothyroidism KW - electron microscopy KW - blood capillaries KW - myocardium KW - rat SP - 229 EP - 233 JF - Wiadomosci lekarskie (Warsaw, Poland : 1960) JO - Wiad. Lek. VL - 72 IS - 2 N2 - OBJECTIVE: Introduction: There is an increasing number of cases of congenital hypothyroidism. One of the most common complications of hypothyroidism is damage to the cardiovascular system, which in 30-50% of patients leads to the development of arterial hypertension. The aim: studying the features of the ultrastructure of myocardial capillaries in mature rats with hypothyroidism. PATIENTS AND METHODS: Materials and methods: Experiments were conducted on 40Wistar line rats with congenital hypothyroidism: juvenile young (45-day) and sexually mature (100-day) rats, as well as intact animals of the corresponding age. While extracted from the experiment rats of all experimental groups had their arterial pressure measured using a plethysmograph while the development of hypothyroidism was controlled by the immune-enzymatic method. Electron microscopic examination of the left ventricular myocardium and morphometric study of volumetric and quantitative densities, cross-section area, and form factor of micropinocytotic vesicles were conducted. RESULTS: Results: In the sexually mature rats with congenital hypothyroidism the quantitative density of the capillaries in the myocardium decreases. Activation of transcytosis is accompanied by significant violations of vesiculation. Some of the endothelial cells of experimental animals contain a moderate amount of transport vesicles, while others are overfilled with these structures and desquamate into the lumen. In older rats with congenital hypothyroidism there is a further dilution of capillaries, the development of hypoxic state in them, mucinous edema of interstitial space, decrease of biosynthetic and transport processes activity. CONCLUSION: Conclusions: In young (45-day) rats with congenital hypothyroidism the direction and expressiveness of compensatory processes is to enhance the transcytosis processes. Dystrophicdestructive changes are manifested by apoptosis in some endothelial cells, decrease in the number of biosynthetic organelles, lysis and edema of their cytoplasm. In sexually mature (100-day) rats with congenital hypothyroidism destructively-dystrophic processes in the blood capillaries of the myocardium are approximately balanced with compensatory-adaptive. SN - 0043-5147 UR - https://www.unboundmedicine.com/medline/citation/30903778/Morphofunctional_status_of_cardio-vascular_system_of_rats_with_congenital_hypothyreosis L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -