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Fecal alpha 1-antitrypsin and hemoglobin excretion in healthy human milk-, formula-, or cow's milk-fed infants.
Pediatrics. 1986 Aug; 78(2):305-12.Ped

Abstract

There is concern that whole cow's milk feedings may be associated with intestinal abnormalities in infants. We studied this issue by measuring random fecal samples for alpha 1-antitrypsin (FA1AT) and hemoglobin (FH) concentrations in 820 healthy infants up to 12 months of age. Subjects were fed either human milk, formula, or fresh whole cow's milk. Solid foods were given ad libitum. Fecal samples were also tested for occult blood with Hematest reagent tablets. None of the infants younger than 6 months of age were receiving fresh whole cow's milk. We found small but statistically significant differences in mean FA1AT between the three feeding groups (P less than .0001): human milk (n = 354) greater than formula (n = 320) greater than cow's milk (n = 146). The younger subjects fed either formula or human milk tended to have higher FA1AT concentrations than did the age-matched subjects who were not consuming solid foods (P less than or equal to .005). Daily FA1AT excretion, FA1AT concentration, and daily stool output were subsequently determined on a separate group of 40 infants 8 to 12 months of age to ascertain whether differences in total daily FA1AT excretion occur in children fed different types of milk. Total daily FA1AT excretion was similar in the three milk feeding groups. An inverse correlation between FA1AT concentration and daily stool output was also found (P less than .001). The overall rate of detectable FH in 792 stool smears was 2.1% and unrelated to type of milk feeding. Of 705 stool smears, 3.5% had positive Hematest reactions.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3090512

Citation

Thomas, D W., et al. "Fecal Alpha 1-antitrypsin and Hemoglobin Excretion in Healthy Human Milk-, Formula-, or Cow's Milk-fed Infants." Pediatrics, vol. 78, no. 2, 1986, pp. 305-12.
Thomas DW, McGilligan KM, Carlson M, et al. Fecal alpha 1-antitrypsin and hemoglobin excretion in healthy human milk-, formula-, or cow's milk-fed infants. Pediatrics. 1986;78(2):305-12.
Thomas, D. W., McGilligan, K. M., Carlson, M., Azen, S. P., Eisenberg, L. D., Lieberman, H. M., & Rissman, E. M. (1986). Fecal alpha 1-antitrypsin and hemoglobin excretion in healthy human milk-, formula-, or cow's milk-fed infants. Pediatrics, 78(2), 305-12.
Thomas DW, et al. Fecal Alpha 1-antitrypsin and Hemoglobin Excretion in Healthy Human Milk-, Formula-, or Cow's Milk-fed Infants. Pediatrics. 1986;78(2):305-12. PubMed PMID: 3090512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fecal alpha 1-antitrypsin and hemoglobin excretion in healthy human milk-, formula-, or cow's milk-fed infants. AU - Thomas,D W, AU - McGilligan,K M, AU - Carlson,M, AU - Azen,S P, AU - Eisenberg,L D, AU - Lieberman,H M, AU - Rissman,E M, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 305 EP - 12 JF - Pediatrics JO - Pediatrics VL - 78 IS - 2 N2 - There is concern that whole cow's milk feedings may be associated with intestinal abnormalities in infants. We studied this issue by measuring random fecal samples for alpha 1-antitrypsin (FA1AT) and hemoglobin (FH) concentrations in 820 healthy infants up to 12 months of age. Subjects were fed either human milk, formula, or fresh whole cow's milk. Solid foods were given ad libitum. Fecal samples were also tested for occult blood with Hematest reagent tablets. None of the infants younger than 6 months of age were receiving fresh whole cow's milk. We found small but statistically significant differences in mean FA1AT between the three feeding groups (P less than .0001): human milk (n = 354) greater than formula (n = 320) greater than cow's milk (n = 146). The younger subjects fed either formula or human milk tended to have higher FA1AT concentrations than did the age-matched subjects who were not consuming solid foods (P less than or equal to .005). Daily FA1AT excretion, FA1AT concentration, and daily stool output were subsequently determined on a separate group of 40 infants 8 to 12 months of age to ascertain whether differences in total daily FA1AT excretion occur in children fed different types of milk. Total daily FA1AT excretion was similar in the three milk feeding groups. An inverse correlation between FA1AT concentration and daily stool output was also found (P less than .001). The overall rate of detectable FH in 792 stool smears was 2.1% and unrelated to type of milk feeding. Of 705 stool smears, 3.5% had positive Hematest reactions.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/3090512/Fecal_alpha_1_antitrypsin_and_hemoglobin_excretion_in_healthy_human_milk__formula__or_cow's_milk_fed_infants_ DB - PRIME DP - Unbound Medicine ER -