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tRNA-derived fragments and tRNA halves: The new players in cancers.
Cancer Lett 2019; 452:31-37CL

Abstract

tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can be divided into tRF-1, tRF-2, tRF-3, tRF-5, and i-tRF; tiRNAs can be divided into 5'tiRNA and 3'tiRNA. Both tRFs and tiRNAs play important roles in tumorigenesis. Some tRFs and tiRNAs promote cell proliferation and cell cycle progression by regulating the expression of oncogenes. Other tRFs and tiRNAs inhibit cancer progression. Mechanism studies have shown that tRFs and tiRNAs may bind to RNA binding proteins such as Y-box binding protein 1 (YBX1) and prevent transcription, inactivate initiation factor eIF4G/A, promote translation of ribosomal proteins, or activate aurora kinase A, the regulator of mitosis. Therefore, tRFs and tiRNAs regulate the occurrence and development of cancers, including lung cancer, colorectal cancer, prostate cancer, breast cancer, ovarian cancer, B cell lymphoma, chronic lymphocytic leukemia, etc. This article reviews the classification of tRFs and tiRNAs, their biological functions in the occurrence of cancers, and their relationships with some common cancers. It will provide new ideas for the diagnosis and treatment of cancers.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China. Electronic address: guojunming@nbu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30905816

Citation

Zhu, Linwen, et al. "TRNA-derived Fragments and tRNA Halves: the New Players in Cancers." Cancer Letters, vol. 452, 2019, pp. 31-37.
Zhu L, Ge J, Li T, et al. TRNA-derived fragments and tRNA halves: The new players in cancers. Cancer Lett. 2019;452:31-37.
Zhu, L., Ge, J., Li, T., Shen, Y., & Guo, J. (2019). TRNA-derived fragments and tRNA halves: The new players in cancers. Cancer Letters, 452, pp. 31-37. doi:10.1016/j.canlet.2019.03.012.
Zhu L, et al. TRNA-derived Fragments and tRNA Halves: the New Players in Cancers. Cancer Lett. 2019 Jun 28;452:31-37. PubMed PMID: 30905816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - tRNA-derived fragments and tRNA halves: The new players in cancers. AU - Zhu,Linwen, AU - Ge,Jiaxin, AU - Li,Tianwen, AU - Shen,Yijing, AU - Guo,Junming, Y1 - 2019/03/21/ PY - 2018/09/22/received PY - 2019/02/25/revised PY - 2019/03/08/accepted PY - 2019/3/25/pubmed PY - 2019/3/25/medline PY - 2019/3/26/entrez KW - Biological function KW - Mechanism KW - Small non-coding RNA KW - Tumorigenesis KW - tRNA SP - 31 EP - 37 JF - Cancer letters JO - Cancer Lett. VL - 452 N2 - tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can be divided into tRF-1, tRF-2, tRF-3, tRF-5, and i-tRF; tiRNAs can be divided into 5'tiRNA and 3'tiRNA. Both tRFs and tiRNAs play important roles in tumorigenesis. Some tRFs and tiRNAs promote cell proliferation and cell cycle progression by regulating the expression of oncogenes. Other tRFs and tiRNAs inhibit cancer progression. Mechanism studies have shown that tRFs and tiRNAs may bind to RNA binding proteins such as Y-box binding protein 1 (YBX1) and prevent transcription, inactivate initiation factor eIF4G/A, promote translation of ribosomal proteins, or activate aurora kinase A, the regulator of mitosis. Therefore, tRFs and tiRNAs regulate the occurrence and development of cancers, including lung cancer, colorectal cancer, prostate cancer, breast cancer, ovarian cancer, B cell lymphoma, chronic lymphocytic leukemia, etc. This article reviews the classification of tRFs and tiRNAs, their biological functions in the occurrence of cancers, and their relationships with some common cancers. It will provide new ideas for the diagnosis and treatment of cancers. SN - 1872-7980 UR - https://www.unboundmedicine.com/medline/citation/30905816/tRNA_derived_fragments_and_tRNA_halves:_The_new_players_in_cancers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(19)30168-5 DB - PRIME DP - Unbound Medicine ER -