Tags

Type your tag names separated by a space and hit enter

Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High-Fat Diet-Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice.
Mol Nutr Food Res 2019; 63(9):e1800937MN

Abstract

SCOPE

Intestinal microbial metabolites from gallotannins (GT), including gallic acid (GA) and pyrogallol (PG), may possess potential anti-obesogenic properties. Lactobacillus plantarum (L. plantarum) found in the intestinal microbiome encodes for enzymatic activities that metabolize GT into GA and PG. Anti-obesogenic activities of orally administered GT in the presence or absence of L. plantarum is examined in gnotobiotic mice fed a high-fat diet (HFD).

METHODS AND RESULTS

Germ-free (GF) C57BL/6J mice are divided into three groups, GF control, GF gavaged with GT, and mice colonized with L. plantarum and gavaged with GT. Compared to the control, GT decreases the expressions of lipogenic genes (e.g., fatty acid synthase (FAS)) in epididymal white adipose tissue and increases thermogenic genes (e.g., nuclear factor erythroid-2-like 1 (Nfe2l1)) in interscapular brown adipose tissue. Intestinal colonization with L. plantarum enhances these effects, and mice colonized with L. plantarum exhibit lower levels of tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), leptin and plasma insulin.

CONCLUSIONS

Results indicate that GT and L. plantarum reduce HFD-induced inflammation, insulin resistance, and promote thermogenesis in adipose tissue potentially through the activity of GT-metabolizing bacterial enzymes yielding absorbable bioactive GT metabolites. These findings imply the potential role of prebiotic-probiotic interactions in the prevention of diet-induced metabolic disorders.

Authors+Show Affiliations

Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, College Station, 77843, TX, USA.Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, College Station, 77843, TX, USA.Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30908878

Citation

Fang, Chuo, et al. "Gallotannins and Lactobacillus Plantarum WCFS1 Mitigate High-Fat Diet-Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice." Molecular Nutrition & Food Research, vol. 63, no. 9, 2019, pp. e1800937.
Fang C, Kim H, Yanagisawa L, et al. Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High-Fat Diet-Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice. Mol Nutr Food Res. 2019;63(9):e1800937.
Fang, C., Kim, H., Yanagisawa, L., Bennett, W., Sirven, M. A., Alaniz, R. C., ... Mertens-Talcott, S. U. (2019). Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High-Fat Diet-Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice. Molecular Nutrition & Food Research, 63(9), pp. e1800937. doi:10.1002/mnfr.201800937.
Fang C, et al. Gallotannins and Lactobacillus Plantarum WCFS1 Mitigate High-Fat Diet-Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice. Mol Nutr Food Res. 2019;63(9):e1800937. PubMed PMID: 30908878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High-Fat Diet-Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice. AU - Fang,Chuo, AU - Kim,Hyemee, AU - Yanagisawa,Lora, AU - Bennett,William, AU - Sirven,Maritza A, AU - Alaniz,Robert C, AU - Talcott,Stephen T, AU - Mertens-Talcott,Susanne U, Y1 - 2019/04/10/ PY - 2018/09/06/received PY - 2018/11/15/revised PY - 2019/3/26/pubmed PY - 2019/11/28/medline PY - 2019/3/26/entrez KW - Lactobacillus plantarum KW - gallotannins KW - gnotobiotic mouse KW - obesity KW - polyphenols KW - thermogenesis SP - e1800937 EP - e1800937 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 63 IS - 9 N2 - SCOPE: Intestinal microbial metabolites from gallotannins (GT), including gallic acid (GA) and pyrogallol (PG), may possess potential anti-obesogenic properties. Lactobacillus plantarum (L. plantarum) found in the intestinal microbiome encodes for enzymatic activities that metabolize GT into GA and PG. Anti-obesogenic activities of orally administered GT in the presence or absence of L. plantarum is examined in gnotobiotic mice fed a high-fat diet (HFD). METHODS AND RESULTS: Germ-free (GF) C57BL/6J mice are divided into three groups, GF control, GF gavaged with GT, and mice colonized with L. plantarum and gavaged with GT. Compared to the control, GT decreases the expressions of lipogenic genes (e.g., fatty acid synthase (FAS)) in epididymal white adipose tissue and increases thermogenic genes (e.g., nuclear factor erythroid-2-like 1 (Nfe2l1)) in interscapular brown adipose tissue. Intestinal colonization with L. plantarum enhances these effects, and mice colonized with L. plantarum exhibit lower levels of tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), leptin and plasma insulin. CONCLUSIONS: Results indicate that GT and L. plantarum reduce HFD-induced inflammation, insulin resistance, and promote thermogenesis in adipose tissue potentially through the activity of GT-metabolizing bacterial enzymes yielding absorbable bioactive GT metabolites. These findings imply the potential role of prebiotic-probiotic interactions in the prevention of diet-induced metabolic disorders. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/30908878/Gallotannins_and_Lactobacillus_plantarum_WCFS1_Mitigate_High_Fat_Diet_Induced_Inflammation_and_Induce_Biomarkers_for_Thermogenesis_in_Adipose_Tissue_in_Gnotobiotic_Mice_ L2 - https://doi.org/10.1002/mnfr.201800937 DB - PRIME DP - Unbound Medicine ER -