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The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease.
Annu Rev Food Sci Technol. 2019 03 25; 10:619-639.AR

Abstract

Improved life expectancy worldwide has resulted in a significant increase in age-related diseases. Dementia is one of the fastest growing age-related diseases, with 75 million adults globally projected to develop the condition by 2030. Alzheimer's disease (AD) is the most common form of dementia and represents the most significant stage of cognitive decline. With no cure identified to date for AD, focus is being placed on preventative strategies to slow progression, minimize the burden of neurological disease, and promote healthy aging. Accumulating evidence suggests that nutrition (e.g., via fruit, vegetables, fish) is important for optimizing cognition and reducing risk of AD. This review examines the role of nutrition on cognition and AD, with specific emphasis on the Mediterranean diet (MeDi) and key nutritional components of the MeDi, namely xanthophyll carotenoids and omega-3 fatty acids. Given their selective presence in the brain and their ability to attenuate proposed mechanisms involved in AD pathogenesis (namely oxidative damage and inflammation), these nutritional compounds offer potential for optimizing cognition and reducing the risk of AD.

Authors+Show Affiliations

Nutrition Research Centre Ireland, School of Health Science, Waterford Institute of Technology, Waterford, Ireland X91 K236; email: jmnolan@wit.ie.Nutrition Research Centre Ireland, School of Health Science, Waterford Institute of Technology, Waterford, Ireland X91 K236; email: jmnolan@wit.ie.Nutrition Research Centre Ireland, School of Health Science, Waterford Institute of Technology, Waterford, Ireland X91 K236; email: jmnolan@wit.ie. Age-Related Care Unit, University Hospital Waterford, Waterford, Ireland X91 ER8E.Howard Foundation, Cambridge, United Kingdom CB22 5LA.Nutrition Research Centre Ireland, School of Health Science, Waterford Institute of Technology, Waterford, Ireland X91 K236; email: jmnolan@wit.ie.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30908950

Citation

Power, Rebecca, et al. "The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease." Annual Review of Food Science and Technology, vol. 10, 2019, pp. 619-639.
Power R, Prado-Cabrero A, Mulcahy R, et al. The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease. Annu Rev Food Sci Technol. 2019;10:619-639.
Power, R., Prado-Cabrero, A., Mulcahy, R., Howard, A., & Nolan, J. M. (2019). The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease. Annual Review of Food Science and Technology, 10, 619-639. https://doi.org/10.1146/annurev-food-030216-030125
Power R, et al. The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease. Annu Rev Food Sci Technol. 2019 03 25;10:619-639. PubMed PMID: 30908950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease. AU - Power,Rebecca, AU - Prado-Cabrero,Alfonso, AU - Mulcahy,Ríona, AU - Howard,Alan, AU - Nolan,John M, PY - 2019/3/26/entrez PY - 2019/3/26/pubmed PY - 2020/8/22/medline KW - Alzheimer's disease KW - Mediterranean diet KW - carotenoids KW - cognition KW - dementia KW - nutrition KW - omega-3 fatty acids KW - prevention SP - 619 EP - 639 JF - Annual review of food science and technology JO - Annu Rev Food Sci Technol VL - 10 N2 - Improved life expectancy worldwide has resulted in a significant increase in age-related diseases. Dementia is one of the fastest growing age-related diseases, with 75 million adults globally projected to develop the condition by 2030. Alzheimer's disease (AD) is the most common form of dementia and represents the most significant stage of cognitive decline. With no cure identified to date for AD, focus is being placed on preventative strategies to slow progression, minimize the burden of neurological disease, and promote healthy aging. Accumulating evidence suggests that nutrition (e.g., via fruit, vegetables, fish) is important for optimizing cognition and reducing risk of AD. This review examines the role of nutrition on cognition and AD, with specific emphasis on the Mediterranean diet (MeDi) and key nutritional components of the MeDi, namely xanthophyll carotenoids and omega-3 fatty acids. Given their selective presence in the brain and their ability to attenuate proposed mechanisms involved in AD pathogenesis (namely oxidative damage and inflammation), these nutritional compounds offer potential for optimizing cognition and reducing the risk of AD. SN - 1941-1421 UR - https://www.unboundmedicine.com/medline/citation/30908950/The_Role_of_Nutrition_for_the_Aging_Population:_Implications_for_Cognition_and_Alzheimer's_Disease_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev-food-030216-030125?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -