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A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis.
Biosci Biotechnol Biochem. 2019 Jul; 83(7):1382-1384.BB

Abstract

Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens.

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Authors+Show Affiliations

Kariu T
a Department of Life Science , Shokei University , Kumamoto , Japan.
Ikeda T
b Faculty of Pharmaceutical Sciences , Sojo University , Kumamoto , Japan.
Nakashima K
b Faculty of Pharmaceutical Sciences , Sojo University , Kumamoto , Japan.
Potempa J
c Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology , Jagiellonian University , Krakow , Poland. d Department of Oral Immunology and Infectious Disease , University of Louisville School of Dentistry , Louisville , KY , USA.
Imamura T
e Department of Molecular Pathology, Faculty of Life Sciences , Kumamoto University , Kumamoto , Japan.

MeSH

Adhesins, BacterialCysteine EndopeptidasesCysteine Proteinase InhibitorsFlavonoidsGingipain Cysteine EndopeptidasesHumansPorphyromonas gingivalisVirulence

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30912703

Citation

Kariu, Toru, et al. "A Natural Anti-periodontitis Agent, Epimedokoreanin B, Inhibits Virulence Activities of Gingipains From Porphyromonas Gingivalis." Bioscience, Biotechnology, and Biochemistry, vol. 83, no. 7, 2019, pp. 1382-1384.
Kariu T, Ikeda T, Nakashima K, et al. A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis. Biosci Biotechnol Biochem. 2019;83(7):1382-1384.
Kariu, T., Ikeda, T., Nakashima, K., Potempa, J., & Imamura, T. (2019). A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis. Bioscience, Biotechnology, and Biochemistry, 83(7), 1382-1384. https://doi.org/10.1080/09168451.2019.1597615
Kariu T, et al. A Natural Anti-periodontitis Agent, Epimedokoreanin B, Inhibits Virulence Activities of Gingipains From Porphyromonas Gingivalis. Biosci Biotechnol Biochem. 2019;83(7):1382-1384. PubMed PMID: 30912703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis. AU - Kariu,Toru, AU - Ikeda,Tsuyoshi, AU - Nakashima,Keisuke, AU - Potempa,Jan, AU - Imamura,Takahisa, Y1 - 2019/03/26/ PY - 2019/3/27/pubmed PY - 2019/8/7/medline PY - 2019/3/27/entrez KW - KW - epimedokoreanin B KW - flavonoids KW - gingipains SP - 1382 EP - 1384 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 83 IS - 7 N2 - Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/30912703/A_natural_anti_periodontitis_agent_epimedokoreanin_B_inhibits_virulence_activities_of_gingipains_from_Porphyromonas_gingivalis_ L2 - https://www.tandfonline.com/doi/full/10.1080/09168451.2019.1597615 DB - PRIME DP - Unbound Medicine ER -