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Diagnosis and management of diarrhea in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Clin Transplant. 2019 09; 33(9):e13550.CT

Abstract

These guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of diarrhea in the pre- and post-transplant period. Diarrhea in an organ transplant recipient may result in significant morbidity including dehydration, increased toxicity of medications, and rejection. Transplant recipients are affected by a wide range of etiologies of diarrhea with the most common causes being Clostridioides (formerly Clostridium) difficile infection, cytomegalovirus, and norovirus. Other bacterial, viral, and parasitic causes can result in diarrhea but are far less common. Further, noninfectious causes including medication toxicity, inflammatory bowel disease, post-transplant lymphoproliferative disease, and malignancy can also result in diarrhea in the transplant population. Management of diarrhea in this population is directed at the cause of the diarrhea, instituting therapy where appropriate and maintaining proper hydration. Identification of the cause to the diarrhea needs to be timely and focused.

Authors+Show Affiliations

Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.Department of Medicine, The Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30913334

Citation

Angarone, Michael, et al. "Diagnosis and Management of Diarrhea in Solid-organ Transplant Recipients: Guidelines From the American Society of Transplantation Infectious Diseases Community of Practice." Clinical Transplantation, vol. 33, no. 9, 2019, pp. e13550.
Angarone M, Snydman DR, AST ID Community of Practice. Diagnosis and management of diarrhea in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13550.
Angarone, M., & Snydman, D. R. (2019). Diagnosis and management of diarrhea in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation, 33(9), e13550. https://doi.org/10.1111/ctr.13550
Angarone M, Snydman DR, AST ID Community of Practice. Diagnosis and Management of Diarrhea in Solid-organ Transplant Recipients: Guidelines From the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13550. PubMed PMID: 30913334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and management of diarrhea in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. AU - Angarone,Michael, AU - Snydman,David R, AU - ,, Y1 - 2019/04/10/ PY - 2019/03/18/received PY - 2019/03/19/accepted PY - 2019/3/27/pubmed PY - 2020/8/19/medline PY - 2019/3/27/entrez KW - Clostridium difficile KW - antibacterial KW - cytomegalovirus KW - diarrhea KW - infection and infectious agents KW - infectious KW - norovirus KW - solid Organ Transplant SP - e13550 EP - e13550 JF - Clinical transplantation JO - Clin Transplant VL - 33 IS - 9 N2 - These guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of diarrhea in the pre- and post-transplant period. Diarrhea in an organ transplant recipient may result in significant morbidity including dehydration, increased toxicity of medications, and rejection. Transplant recipients are affected by a wide range of etiologies of diarrhea with the most common causes being Clostridioides (formerly Clostridium) difficile infection, cytomegalovirus, and norovirus. Other bacterial, viral, and parasitic causes can result in diarrhea but are far less common. Further, noninfectious causes including medication toxicity, inflammatory bowel disease, post-transplant lymphoproliferative disease, and malignancy can also result in diarrhea in the transplant population. Management of diarrhea in this population is directed at the cause of the diarrhea, instituting therapy where appropriate and maintaining proper hydration. Identification of the cause to the diarrhea needs to be timely and focused. SN - 1399-0012 UR - https://www.unboundmedicine.com/medline/citation/30913334/Diagnosis_and_management_of_diarrhea_in_solid_organ_transplant_recipients:_Guidelines_from_the_American_Society_of_Transplantation_Infectious_Diseases_Community_of_Practice_ L2 - https://doi.org/10.1111/ctr.13550 DB - PRIME DP - Unbound Medicine ER -