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Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.
Euro Surveill. 2019 Mar; 24(12)ES

Abstract

In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans.

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Authors+Show Affiliations

Takashita E
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Kawakami C
Yokohama City Institute of Public Health, Kanagawa, Japan.
Ogawa R
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Morita H
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Fujisaki S
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Shirakura M
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Miura H
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Nakamura K
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Kishida N
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Kuwahara T
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Ota A
Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan.
Togashi H
Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan.
Saito A
Saito Children's Clinic, Kanagawa, Japan.
Mitamura K
Eiju General Hospital, Tokyo, Japan.
Abe T
Abe Children's Clinic, Kanagawa, Japan.
Ichikawa M
Ichikawa Children's Clinic, Kanagawa, Japan.
Yamazaki M
Zama Children's Clinic, Kanagawa, Japan.
Watanabe S
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Odagiri T
Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

MeSH

AdolescentAdultAntiviral AgentsChildDibenzothiepinsDrug Resistance, ViralEnzyme InhibitorsHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanInpatientsJapanMiddle AgedMorpholinesOxazinesPolymerase Chain ReactionPyridinesPyridonesThiepinsTreatment OutcomeTriazinesYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30914078

Citation

Takashita, Emi, et al. "Influenza A(H3N2) Virus Exhibiting Reduced Susceptibility to Baloxavir Due to a Polymerase Acidic Subunit I38T Substitution Detected From a Hospitalised Child Without Prior Baloxavir Treatment, Japan, January 2019." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 24, no. 12, 2019.
Takashita E, Kawakami C, Ogawa R, et al. Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019. Euro Surveill. 2019;24(12).
Takashita, E., Kawakami, C., Ogawa, R., Morita, H., Fujisaki, S., Shirakura, M., Miura, H., Nakamura, K., Kishida, N., Kuwahara, T., Ota, A., Togashi, H., Saito, A., Mitamura, K., Abe, T., Ichikawa, M., Yamazaki, M., Watanabe, S., & Odagiri, T. (2019). Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 24(12). https://doi.org/10.2807/1560-7917.ES.2019.24.12.1900170
Takashita E, et al. Influenza A(H3N2) Virus Exhibiting Reduced Susceptibility to Baloxavir Due to a Polymerase Acidic Subunit I38T Substitution Detected From a Hospitalised Child Without Prior Baloxavir Treatment, Japan, January 2019. Euro Surveill. 2019;24(12) PubMed PMID: 30914078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019. AU - Takashita,Emi, AU - Kawakami,Chiharu, AU - Ogawa,Rie, AU - Morita,Hiroko, AU - Fujisaki,Seiichiro, AU - Shirakura,Masayuki, AU - Miura,Hideka, AU - Nakamura,Kazuya, AU - Kishida,Noriko, AU - Kuwahara,Tomoko, AU - Ota,Akira, AU - Togashi,Hayato, AU - Saito,Ayako, AU - Mitamura,Keiko, AU - Abe,Takashi, AU - Ichikawa,Masataka, AU - Yamazaki,Masahiko, AU - Watanabe,Shinji, AU - Odagiri,Takato, PY - 2019/3/28/entrez PY - 2019/3/28/pubmed PY - 2020/7/9/medline KW - Influenza virus KW - baloxavir acid KW - baloxavir marboxil KW - cap-dependent endonuclease inhibitor KW - drug resistance JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 24 IS - 12 N2 - In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/30914078/Influenza_A_H3N2__virus_exhibiting_reduced_susceptibility_to_baloxavir_due_to_a_polymerase_acidic_subunit_I38T_substitution_detected_from_a_hospitalised_child_without_prior_baloxavir_treatment_Japan_January_2019_ DB - PRIME DP - Unbound Medicine ER -