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Survival and life-expectancy in a young-onset dementia cohort with six years of follow-up: the NeedYD-study.
Int Psychogeriatr. 2019 12; 31(12):1781-1789.IP

Abstract

OBJECTIVES

The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity.

DESIGN, SETTING AND PARTICIPANTS

Survival was examined in 198 participants in the Needs in Young-onset Dementia study, including participants with Alzheimer's dementia (AD), vascular dementia (VaD) and frontotemporal dementia (FTD).

MEASURES

The primary outcomes were survival time after symptom onset and after date of diagnosis. Cox proportional hazards models were used to explore the relationship between survival and age, sex, dementia subtype and comorbidity. Additionally, the impact on remaining life expectancy was explored.

RESULTS

During the six-year follow-up, 77 of the participants died (38.9%), 78 participants survived (39.4%) and 43 were lost to follow-up (21.7%). The mean survival time after symptom onset and diagnosis was 209 months (95% CI 185-233) and 120 months (95% CI 110-130) respectively. Participants with AD had a statistically significant shorter survival compared with VaD participants, both regarding survival after symptom onset (p = 0.047) as well as regarding survival after diagnosis (p = 0.049). Younger age at symptom onset or at diagnosis was associated with longer survival times. The remaining life expectancy, after diagnosis, was reduced with 51% for males and 59% for females compared to the life expectancy of the general population in the same age groups.

CONCLUSION/IMPLICATIONS

It is important to consider the dementia subtype when persons with YOD and their families are informed about the prognosis of survival. Our study suggests longer survival times compared to other studies on YOD, and survival is prolonged compared to studies on LOD. Younger age at symptom onset or at diagnosis was positively related to survival but diagnosis at younger ages, nevertheless, still diminishes life expectancy dramatically.

Authors+Show Affiliations

De Wever, Centre for Elderly Care, Tilburg, the Netherlands. Department of Primary and Community Care, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands. Radboud University Medical Centre, Alzheimer Centre, Nijmegen, the Netherlands.Department of Primary and Community Care, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands. Radboud University Medical Centre, Alzheimer Centre, Nijmegen, the Netherlands. Florence, Mariahoeve, Centre for Specialized Care in Young-onset Dementia, Den Haag, the Netherlands.School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Neurology and Alzheimer Centre, Amsterdam University Medical Centres, Amsterdam Neuroscience, Amsterdam, the Netherlands.School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University Medical Centre, Maastricht, the Netherlands.School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Primary and Community Care, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands. Radboud University Medical Centre, Alzheimer Centre, Nijmegen, the Netherlands. Joachim en Anna, Centre for Specialized Geriatric Care, Nijmegen, the Netherlands.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30915930

Citation

Gerritsen, Adrie A J., et al. "Survival and Life-expectancy in a Young-onset Dementia Cohort With Six Years of Follow-up: the NeedYD-study." International Psychogeriatrics, vol. 31, no. 12, 2019, pp. 1781-1789.
Gerritsen AAJ, Bakker C, Verhey FRJ, et al. Survival and life-expectancy in a young-onset dementia cohort with six years of follow-up: the NeedYD-study. Int Psychogeriatr. 2019;31(12):1781-1789.
Gerritsen, A. A. J., Bakker, C., Verhey, F. R. J., Pijnenburg, Y. A. L., Millenaar, J. K., de Vugt, M. E., & Koopmans, R. T. C. M. (2019). Survival and life-expectancy in a young-onset dementia cohort with six years of follow-up: the NeedYD-study. International Psychogeriatrics, 31(12), 1781-1789. https://doi.org/10.1017/S1041610219000152
Gerritsen AAJ, et al. Survival and Life-expectancy in a Young-onset Dementia Cohort With Six Years of Follow-up: the NeedYD-study. Int Psychogeriatr. 2019;31(12):1781-1789. PubMed PMID: 30915930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survival and life-expectancy in a young-onset dementia cohort with six years of follow-up: the NeedYD-study. AU - Gerritsen,Adrie A J, AU - Bakker,Christian, AU - Verhey,Frans R J, AU - Pijnenburg,Yolande A L, AU - Millenaar,Joany K, AU - de Vugt,Marjolein E, AU - Koopmans,Raymond T C M, Y1 - 2019/03/27/ PY - 2019/3/28/pubmed PY - 2020/5/28/medline PY - 2019/3/28/entrez KW - Dementia KW - Long-Term Care KW - Young Onset Dementia SP - 1781 EP - 1789 JF - International psychogeriatrics JO - Int Psychogeriatr VL - 31 IS - 12 N2 - OBJECTIVES: The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity. DESIGN, SETTING AND PARTICIPANTS: Survival was examined in 198 participants in the Needs in Young-onset Dementia study, including participants with Alzheimer's dementia (AD), vascular dementia (VaD) and frontotemporal dementia (FTD). MEASURES: The primary outcomes were survival time after symptom onset and after date of diagnosis. Cox proportional hazards models were used to explore the relationship between survival and age, sex, dementia subtype and comorbidity. Additionally, the impact on remaining life expectancy was explored. RESULTS: During the six-year follow-up, 77 of the participants died (38.9%), 78 participants survived (39.4%) and 43 were lost to follow-up (21.7%). The mean survival time after symptom onset and diagnosis was 209 months (95% CI 185-233) and 120 months (95% CI 110-130) respectively. Participants with AD had a statistically significant shorter survival compared with VaD participants, both regarding survival after symptom onset (p = 0.047) as well as regarding survival after diagnosis (p = 0.049). Younger age at symptom onset or at diagnosis was associated with longer survival times. The remaining life expectancy, after diagnosis, was reduced with 51% for males and 59% for females compared to the life expectancy of the general population in the same age groups. CONCLUSION/IMPLICATIONS: It is important to consider the dementia subtype when persons with YOD and their families are informed about the prognosis of survival. Our study suggests longer survival times compared to other studies on YOD, and survival is prolonged compared to studies on LOD. Younger age at symptom onset or at diagnosis was positively related to survival but diagnosis at younger ages, nevertheless, still diminishes life expectancy dramatically. SN - 1741-203X UR - https://www.unboundmedicine.com/medline/citation/30915930/Survival_and_life_expectancy_in_a_young_onset_dementia_cohort_with_six_years_of_follow_up:_the_NeedYD_study_ DB - PRIME DP - Unbound Medicine ER -