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Breast milk: To each his own. From metabolomic study, evidence of personalized nutrition in preterm infants.

Abstract

OBJECTIVES

The composition of milk from mothers delivering prematurely differs from that of full-term mature milk and changes over time. The aim of this study is to test the hypothesis that changes in milk metabolomic profile from mothers delivering prematurely persist over time when compared with mothers delivering at term.

METHODS

Nuclear magnetic resonance spectroscopy was used to analyze the metabolome pattern of human milk samples collected from 18 mothers. Twelve mothers collected 12 term milk samples (one for each mother) once between 4 and 7 d after delivery. Six mothers delivering prematurely (29-31 wk of gestational age) and collected three samples each, once a week after delivery until the third week after birth.

RESULTS

Principal component analysis identified two distinct metabolite groups, one represented by the 18 preterm milk samples and the other by term milk samples. Metabolite profiling identified that lactose and oligosaccharide levels were significantly more represented in preterm than in milk term samples.

CONCLUSIONS

The preterm milk metabolome pattern undergoes maturation during the first 3 wk after birth, but at the end of the third week it still does not resemble the term milk pattern. The specific changes in mothers' milk metabolomic profiles according to their offspring might reflect the different nutritional requirement of each preterm infant. This knowledge is crucial to move from standardized nutritional protocols to tailored, individualized nutrition in preterm infants.

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  • Authors+Show Affiliations

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    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address: Saraspv@yahoo.it.

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    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

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    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

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    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

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    NMR Center, University of Siena, Siena, Italy.

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    NMR Center, University of Siena, Siena, Italy.

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    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

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    Kode Solutions, Pisa, Italy.

    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    30921551

    Citation

    Perrone, Serafina, et al. "Breast Milk: to Each His Own. From Metabolomic Study, Evidence of Personalized Nutrition in Preterm Infants." Nutrition (Burbank, Los Angeles County, Calif.), vol. 62, 2019, pp. 158-161.
    Perrone S, Longini M, Zollino I, et al. Breast milk: To each his own. From metabolomic study, evidence of personalized nutrition in preterm infants. Nutrition. 2019;62:158-161.
    Perrone, S., Longini, M., Zollino, I., Bazzini, F., Tassini, M., Vivi, A., ... Buonocore, G. (2019). Breast milk: To each his own. From metabolomic study, evidence of personalized nutrition in preterm infants. Nutrition (Burbank, Los Angeles County, Calif.), 62, pp. 158-161. doi:10.1016/j.nut.2018.12.015.
    Perrone S, et al. Breast Milk: to Each His Own. From Metabolomic Study, Evidence of Personalized Nutrition in Preterm Infants. Nutrition. 2019;62:158-161. PubMed PMID: 30921551.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breast milk: To each his own. From metabolomic study, evidence of personalized nutrition in preterm infants. AU - Perrone,Serafina, AU - Longini,Mariangela, AU - Zollino,Ilaria, AU - Bazzini,Francesco, AU - Tassini,Maria, AU - Vivi,Antonio, AU - Bracciali,Carlotta, AU - Calderisi,Marco, AU - Buonocore,Giuseppe, Y1 - 2019/01/25/ PY - 2018/08/24/received PY - 2018/11/21/revised PY - 2018/12/20/accepted PY - 2019/3/29/pubmed PY - 2019/3/29/medline PY - 2019/3/29/entrez KW - Human milk KW - Metabolomics KW - NMR spectroscopy KW - Nutrition KW - Preterm SP - 158 EP - 161 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 62 N2 - OBJECTIVES: The composition of milk from mothers delivering prematurely differs from that of full-term mature milk and changes over time. The aim of this study is to test the hypothesis that changes in milk metabolomic profile from mothers delivering prematurely persist over time when compared with mothers delivering at term. METHODS: Nuclear magnetic resonance spectroscopy was used to analyze the metabolome pattern of human milk samples collected from 18 mothers. Twelve mothers collected 12 term milk samples (one for each mother) once between 4 and 7 d after delivery. Six mothers delivering prematurely (29-31 wk of gestational age) and collected three samples each, once a week after delivery until the third week after birth. RESULTS: Principal component analysis identified two distinct metabolite groups, one represented by the 18 preterm milk samples and the other by term milk samples. Metabolite profiling identified that lactose and oligosaccharide levels were significantly more represented in preterm than in milk term samples. CONCLUSIONS: The preterm milk metabolome pattern undergoes maturation during the first 3 wk after birth, but at the end of the third week it still does not resemble the term milk pattern. The specific changes in mothers' milk metabolomic profiles according to their offspring might reflect the different nutritional requirement of each preterm infant. This knowledge is crucial to move from standardized nutritional protocols to tailored, individualized nutrition in preterm infants. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/30921551/Breast_milk:_To_each_his_own._From_metabolomic_study,_evidence_of_personalized_nutrition_in_preterm_infants L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(18)30948-1 DB - PRIME DP - Unbound Medicine ER -