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Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes.
Yale J Biol Med 2019; 92(1):63-80YJ

Abstract

Slow-wave sleep (SWS) is involved in the overnight consolidation of declarative memories. Recent efforts using auditory stimulation, slow-oscillatory transcranial direct current stimulation (so-tDCS), and pharmacological agents have targeted sleep slow-waves as a method for enhancing cognitive performance. However, no studies thus far have integrated current evidence to provide a preliminary review of the effects of SWS enhancement on memory and other cognitive outcomes. The objective of this review was to synthesize the results of recent experimental studies that have used auditory stimulation, electrical, and pharmacological methods to boost both SWS and cognitive performance. A systematic review was done to identify and consolidate all currently existing empirical studies in this area. We found that each stimulation method could enhance slow-wave power and/or SWS duration in human subjects. Closed-loop, in-phase auditory stimulation enhanced verbal declarative memory in healthy adults. Electrical stimulation using so-tDCS showed some efficacy in promoting verbal declarative memory, picture recognition memory, and location memory. Interleukin-6 and sodium oxybate enhanced declarative verbal memory, while tiagabine and sodium oxybate improved some non-memory measures of cognitive performance. There is some evidence that so-tDCS can also improve certain cognitive outcomes in clinical populations. Overall, future studies should recruit larger sample sizes drawn from more diverse populations, and determine clinical significance and effect sizes of each enhancement methodology.

Authors+Show Affiliations

Department of Psychology, McGill University, Montréal, QC, Canada.Department of Psychiatry, McGill University, Montréal, QC, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30923474

Citation

Zhang, Yujie, and Reut Gruber. "Can Slow-Wave Sleep Enhancement Improve Memory? a Review of Current Approaches and Cognitive Outcomes." The Yale Journal of Biology and Medicine, vol. 92, no. 1, 2019, pp. 63-80.
Zhang Y, Gruber R. Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes. Yale J Biol Med. 2019;92(1):63-80.
Zhang, Y., & Gruber, R. (2019). Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes. The Yale Journal of Biology and Medicine, 92(1), pp. 63-80.
Zhang Y, Gruber R. Can Slow-Wave Sleep Enhancement Improve Memory? a Review of Current Approaches and Cognitive Outcomes. Yale J Biol Med. 2019;92(1):63-80. PubMed PMID: 30923474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes. AU - Zhang,Yujie, AU - Gruber,Reut, Y1 - 2019/03/25/ PY - 2019/3/30/entrez PY - 2019/3/30/pubmed PY - 2019/8/9/medline KW - Auditory stimulation KW - Cognition KW - Direct current stimulation KW - Humans KW - Memory KW - Sleep slow oscillations KW - Sleep spindles KW - Slow-wave enhancement KW - Slow-wave sleep KW - Sustained attention SP - 63 EP - 80 JF - The Yale journal of biology and medicine JO - Yale J Biol Med VL - 92 IS - 1 N2 - Slow-wave sleep (SWS) is involved in the overnight consolidation of declarative memories. Recent efforts using auditory stimulation, slow-oscillatory transcranial direct current stimulation (so-tDCS), and pharmacological agents have targeted sleep slow-waves as a method for enhancing cognitive performance. However, no studies thus far have integrated current evidence to provide a preliminary review of the effects of SWS enhancement on memory and other cognitive outcomes. The objective of this review was to synthesize the results of recent experimental studies that have used auditory stimulation, electrical, and pharmacological methods to boost both SWS and cognitive performance. A systematic review was done to identify and consolidate all currently existing empirical studies in this area. We found that each stimulation method could enhance slow-wave power and/or SWS duration in human subjects. Closed-loop, in-phase auditory stimulation enhanced verbal declarative memory in healthy adults. Electrical stimulation using so-tDCS showed some efficacy in promoting verbal declarative memory, picture recognition memory, and location memory. Interleukin-6 and sodium oxybate enhanced declarative verbal memory, while tiagabine and sodium oxybate improved some non-memory measures of cognitive performance. There is some evidence that so-tDCS can also improve certain cognitive outcomes in clinical populations. Overall, future studies should recruit larger sample sizes drawn from more diverse populations, and determine clinical significance and effect sizes of each enhancement methodology. SN - 1551-4056 UR - https://www.unboundmedicine.com/medline/citation/30923474/Can_Slow-Wave_Sleep_Enhancement_Improve_Memory_A_Review_of_Current_Approaches_and_Cognitive_Outcomes L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30923474/ DB - PRIME DP - Unbound Medicine ER -