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Liposomal bupivacaine reduces opiate consumption after rotator cuff repair in a randomized controlled trial.
J Shoulder Elbow Surg. 2019 May; 28(5):819-827.JS

Abstract

BACKGROUND

Arthroscopic rotator cuff repair (ARCR) provides excellent clinical outcomes but is often associated with significant postoperative pain. The use of intraoperative anesthesia in conjunction with multimodal pharmacologic strategies is a widely accepted approach for managing surgical pain and reducing opiate use. The purpose of this study was to determine whether using a combined field and suprascapular nerve block with liposomal bupivacaine (LB) in addition to an interscalene block would provide greater pain relief and a reduction in opiate consumption compared with an interscalene block alone.

METHODS

The study enrolled 50 patients with full-thickness rotator cuff tears undergoing primary ARCR surgery. Patients were randomized to receive intraoperative LB (n = 25) or not (n = 25) and given postoperative "pain journals" to document visual analog scale pain scores and to track their daily opioid consumption during the first 5 postoperative days.

RESULTS

Patients in the LB group reported statistically and clinically lower pain scores during postoperative days 1 and 2 (P < .0001 and P = .03, respectively). In addition, patients in the LB group consumed significantly fewer narcotics than the control group during the 5-day period, demonstrating a 64% reduction in total narcotic consumption (P = .002).

CONCLUSION

The findings of this study suggest that the addition of LB to multimodal anesthetic protocols significantly reduces the acute perioperative pain experienced following rotator cuff repair and the number of narcotic pills consumed in the first 5 days after ARCR. Furthermore, the findings provide guidelines for postoperative narcotic prescribing to reduce the quantity of opiates prescribed.

Authors+Show Affiliations

Orthopaedic & Neurosurgery Specialists, Greenwich, CT, USA; The ONS Foundation for Clinical Research and Education, Greenwich, CT, USA. Electronic address: sethi@onsmd.com.The ONS Foundation for Clinical Research and Education, Greenwich, CT, USA.The ONS Foundation for Clinical Research and Education, Greenwich, CT, USA.The ONS Foundation for Clinical Research and Education, Greenwich, CT, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30928396

Citation

Sethi, Paul M., et al. "Liposomal Bupivacaine Reduces Opiate Consumption After Rotator Cuff Repair in a Randomized Controlled Trial." Journal of Shoulder and Elbow Surgery, vol. 28, no. 5, 2019, pp. 819-827.
Sethi PM, Brameier DT, Mandava NK, et al. Liposomal bupivacaine reduces opiate consumption after rotator cuff repair in a randomized controlled trial. J Shoulder Elbow Surg. 2019;28(5):819-827.
Sethi, P. M., Brameier, D. T., Mandava, N. K., & Miller, S. R. (2019). Liposomal bupivacaine reduces opiate consumption after rotator cuff repair in a randomized controlled trial. Journal of Shoulder and Elbow Surgery, 28(5), 819-827. https://doi.org/10.1016/j.jse.2019.01.008
Sethi PM, et al. Liposomal Bupivacaine Reduces Opiate Consumption After Rotator Cuff Repair in a Randomized Controlled Trial. J Shoulder Elbow Surg. 2019;28(5):819-827. PubMed PMID: 30928396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liposomal bupivacaine reduces opiate consumption after rotator cuff repair in a randomized controlled trial. AU - Sethi,Paul M, AU - Brameier,Devon T, AU - Mandava,Nikhil K, AU - Miller,Seth R, Y1 - 2019/03/28/ PY - 2018/10/15/received PY - 2019/01/03/revised PY - 2019/01/06/accepted PY - 2019/4/1/pubmed PY - 2019/7/19/medline PY - 2019/4/1/entrez KW - Postoperative care KW - analgesia KW - liposomal bupivacaine KW - opioid epidemic KW - pain management KW - rotator cuff repair SP - 819 EP - 827 JF - Journal of shoulder and elbow surgery JO - J Shoulder Elbow Surg VL - 28 IS - 5 N2 - BACKGROUND: Arthroscopic rotator cuff repair (ARCR) provides excellent clinical outcomes but is often associated with significant postoperative pain. The use of intraoperative anesthesia in conjunction with multimodal pharmacologic strategies is a widely accepted approach for managing surgical pain and reducing opiate use. The purpose of this study was to determine whether using a combined field and suprascapular nerve block with liposomal bupivacaine (LB) in addition to an interscalene block would provide greater pain relief and a reduction in opiate consumption compared with an interscalene block alone. METHODS: The study enrolled 50 patients with full-thickness rotator cuff tears undergoing primary ARCR surgery. Patients were randomized to receive intraoperative LB (n = 25) or not (n = 25) and given postoperative "pain journals" to document visual analog scale pain scores and to track their daily opioid consumption during the first 5 postoperative days. RESULTS: Patients in the LB group reported statistically and clinically lower pain scores during postoperative days 1 and 2 (P < .0001 and P = .03, respectively). In addition, patients in the LB group consumed significantly fewer narcotics than the control group during the 5-day period, demonstrating a 64% reduction in total narcotic consumption (P = .002). CONCLUSION: The findings of this study suggest that the addition of LB to multimodal anesthetic protocols significantly reduces the acute perioperative pain experienced following rotator cuff repair and the number of narcotic pills consumed in the first 5 days after ARCR. Furthermore, the findings provide guidelines for postoperative narcotic prescribing to reduce the quantity of opiates prescribed. SN - 1532-6500 UR - https://www.unboundmedicine.com/medline/citation/30928396/Liposomal_bupivacaine_reduces_opiate_consumption_after_rotator_cuff_repair_in_a_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -