Tags

Type your tag names separated by a space and hit enter

Dietary protein intake and subsequent risk of type 2 diabetes: a dose-response meta-analysis of prospective cohort studies.
Acta Diabetol. 2019 Aug; 56(8):851-870.AD

Abstract

AIMS

Dietary proteins, including those obtained from animal and plant sources, have inconsistently been correlated with type 2 diabetes mellitus (T2DM) risk. Therefore, a meta-analysis was conducted to evaluate the association between dietary proteins and the risk of T2DM.

METHODS

Prospective cohort studies published until November 2018 were systematically searched in PubMed, Embase, and the Cochrane library. The pooled relative risks (RRs) were calculated with 95% confidence intervals (CIs) using the random-effects model.

RESULTS

Ten articles involving a total of 21 cohorts were included in the final meta-analysis. A total of 487,956 individuals were recruited in these studies and 38,350 T2DM cases were reported. Analysis of the pooled RRs indicated that high total protein intake was associated with an increased risk of T2DM (RR 1.10; P = 0.006), whereas moderate total protein intake was not significantly associated with T2DM risk (RR 1.00; P = 0.917). Moreover, a higher risk of T2DM was observed with high animal protein intake (RR 1.13; P = 0.013), whereas moderate animal protein intake had little or no effect on T2DM risk (RR 1.06; P = 0.058). Finally, high intake of plant protein did not affect T2DM risk (RR 0.93; P = 0.074), whereas moderate intake was associated with a reduced risk of T2DM (RR 0.94; P < 0.001).

CONCLUSIONS

The results of this study indicate that high total protein and animal protein intakes are associated with an increased risk of T2DM, whereas moderate plant protein intake is associated with a decreased risk of T2DM.

Authors+Show Affiliations

Department of Endocrinology, Foshan Hospital of TCM, Foshan, 528000, China.Department of Endocrinology, Foshan Hospital of TCM, Foshan, 528000, China.Department of Endocrinology, Foshan Hospital of TCM, Foshan, 528000, China.Department of Endocrinology, Foshan Hospital of TCM, Foshan, 528000, China.Department of Endocrinology, Foshan Hospital of TCM, Foshan, 528000, China.Functional Department, Foshan Hospital of TCM, No.6 Qinren Road, Chancheng District, Foshan, 528000, China. fszyyyjh@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

30929078

Citation

Ye, Jianhong, et al. "Dietary Protein Intake and Subsequent Risk of Type 2 Diabetes: a Dose-response Meta-analysis of Prospective Cohort Studies." Acta Diabetologica, vol. 56, no. 8, 2019, pp. 851-870.
Ye J, Yu Q, Mai W, et al. Dietary protein intake and subsequent risk of type 2 diabetes: a dose-response meta-analysis of prospective cohort studies. Acta Diabetol. 2019;56(8):851-870.
Ye, J., Yu, Q., Mai, W., Liang, P., Liu, X., & Wang, Y. (2019). Dietary protein intake and subsequent risk of type 2 diabetes: a dose-response meta-analysis of prospective cohort studies. Acta Diabetologica, 56(8), 851-870. https://doi.org/10.1007/s00592-019-01320-x
Ye J, et al. Dietary Protein Intake and Subsequent Risk of Type 2 Diabetes: a Dose-response Meta-analysis of Prospective Cohort Studies. Acta Diabetol. 2019;56(8):851-870. PubMed PMID: 30929078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary protein intake and subsequent risk of type 2 diabetes: a dose-response meta-analysis of prospective cohort studies. AU - Ye,Jianhong, AU - Yu,Qixin, AU - Mai,Weihua, AU - Liang,Peiling, AU - Liu,Xiaoxia, AU - Wang,Yunnan, Y1 - 2019/03/30/ PY - 2019/01/23/received PY - 2019/03/05/accepted PY - 2019/4/1/pubmed PY - 2019/10/16/medline PY - 2019/4/1/entrez KW - Dietary proteins KW - Energy intake KW - Meta-analysis KW - Type 2 diabetes mellitus SP - 851 EP - 870 JF - Acta diabetologica JO - Acta Diabetol VL - 56 IS - 8 N2 - AIMS: Dietary proteins, including those obtained from animal and plant sources, have inconsistently been correlated with type 2 diabetes mellitus (T2DM) risk. Therefore, a meta-analysis was conducted to evaluate the association between dietary proteins and the risk of T2DM. METHODS: Prospective cohort studies published until November 2018 were systematically searched in PubMed, Embase, and the Cochrane library. The pooled relative risks (RRs) were calculated with 95% confidence intervals (CIs) using the random-effects model. RESULTS: Ten articles involving a total of 21 cohorts were included in the final meta-analysis. A total of 487,956 individuals were recruited in these studies and 38,350 T2DM cases were reported. Analysis of the pooled RRs indicated that high total protein intake was associated with an increased risk of T2DM (RR 1.10; P = 0.006), whereas moderate total protein intake was not significantly associated with T2DM risk (RR 1.00; P = 0.917). Moreover, a higher risk of T2DM was observed with high animal protein intake (RR 1.13; P = 0.013), whereas moderate animal protein intake had little or no effect on T2DM risk (RR 1.06; P = 0.058). Finally, high intake of plant protein did not affect T2DM risk (RR 0.93; P = 0.074), whereas moderate intake was associated with a reduced risk of T2DM (RR 0.94; P < 0.001). CONCLUSIONS: The results of this study indicate that high total protein and animal protein intakes are associated with an increased risk of T2DM, whereas moderate plant protein intake is associated with a decreased risk of T2DM. SN - 1432-5233 UR - https://www.unboundmedicine.com/medline/citation/30929078/Dietary_protein_intake_and_subsequent_risk_of_type_2_diabetes:_a_dose_response_meta_analysis_of_prospective_cohort_studies_ L2 - https://dx.doi.org/10.1007/s00592-019-01320-x DB - PRIME DP - Unbound Medicine ER -