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Oxidation of Pharmaceuticals by Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents.
Environ Sci Technol. 2019 05 07; 53(9):5272-5281.ES

Abstract

Destruction of pharmaceuticals excreted in urine can be an efficient approach to eliminate these environmental pollutants. However, urine contains high concentrations of chloride, ammonium, and bicarbonate, which may hinder treatment processes. This study evaluated the application of ferrate(VI) (FeVIO42-, Fe(VI)) to oxidize pharmaceuticals (carbamazepine (CBZ), naproxen (NAP), trimethoprim (TMP), and sulfonamide antibiotics (SAs)) in synthetic hydrolyzed human urine and uncovered new effects from urine's major inorganic constituents. Chloride slightly decreased pharmaceuticals' removal rate by Fe(VI) due to the ionic strength effect. Ammonium (0.5 M) in undiluted hydrolyzed urine posed a strong scavenging effect, but lower concentrations (≤0.25 M) of ammonium enhanced the pharmaceuticals' degradation by 300 μM Fe(VI), likely due to the reactive ammonium complex form of Fe(V)/Fe(IV). For the first time, bicarbonate was found to significantly promote the oxidation of aniline-containing SAs by Fe(VI) and alter the reaction stoichiometry of Fe(VI) and SA from 4:1 to 3:1. In depth investigation indicated that bicarbonate not only changed the Fe(VI)/SA complexation ratio from 1:2 to 1:1 but provided a stabilizing effect for Fe(V) intermediate formed in situ, enabling its degradation of SAs. Overall, the results of this study suggested that Fe(VI) is a promising oxidant for the removal of pharmaceuticals in hydrolyzed urine.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Luo C
School of Civil and Environmental Engineering , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.
Feng M
Department of Environment and Occupational Health, School of Public Health , Texas A&M University , College Station , Texas 77843 , United States.
Sharma VK
Department of Environment and Occupational Health, School of Public Health , Texas A&M University , College Station , Texas 77843 , United States.
Huang CH
School of Civil and Environmental Engineering , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.

MeSH

HumansIronKineticsOxidantsOxidation-ReductionWater Pollutants, ChemicalWater Purification

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

30933490

Citation

Luo, Cong, et al. "Oxidation of Pharmaceuticals By Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents." Environmental Science & Technology, vol. 53, no. 9, 2019, pp. 5272-5281.
Luo C, Feng M, Sharma VK, et al. Oxidation of Pharmaceuticals by Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents. Environ Sci Technol. 2019;53(9):5272-5281.
Luo, C., Feng, M., Sharma, V. K., & Huang, C. H. (2019). Oxidation of Pharmaceuticals by Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents. Environmental Science & Technology, 53(9), 5272-5281. https://doi.org/10.1021/acs.est.9b00006
Luo C, et al. Oxidation of Pharmaceuticals By Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents. Environ Sci Technol. 2019 05 7;53(9):5272-5281. PubMed PMID: 30933490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidation of Pharmaceuticals by Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents. AU - Luo,Cong, AU - Feng,Mingbao, AU - Sharma,Virender K, AU - Huang,Ching-Hua, Y1 - 2019/04/11/ PY - 2019/4/2/pubmed PY - 2019/9/19/medline PY - 2019/4/2/entrez SP - 5272 EP - 5281 JF - Environmental science & technology JO - Environ Sci Technol VL - 53 IS - 9 N2 - Destruction of pharmaceuticals excreted in urine can be an efficient approach to eliminate these environmental pollutants. However, urine contains high concentrations of chloride, ammonium, and bicarbonate, which may hinder treatment processes. This study evaluated the application of ferrate(VI) (FeVIO42-, Fe(VI)) to oxidize pharmaceuticals (carbamazepine (CBZ), naproxen (NAP), trimethoprim (TMP), and sulfonamide antibiotics (SAs)) in synthetic hydrolyzed human urine and uncovered new effects from urine's major inorganic constituents. Chloride slightly decreased pharmaceuticals' removal rate by Fe(VI) due to the ionic strength effect. Ammonium (0.5 M) in undiluted hydrolyzed urine posed a strong scavenging effect, but lower concentrations (≤0.25 M) of ammonium enhanced the pharmaceuticals' degradation by 300 μM Fe(VI), likely due to the reactive ammonium complex form of Fe(V)/Fe(IV). For the first time, bicarbonate was found to significantly promote the oxidation of aniline-containing SAs by Fe(VI) and alter the reaction stoichiometry of Fe(VI) and SA from 4:1 to 3:1. In depth investigation indicated that bicarbonate not only changed the Fe(VI)/SA complexation ratio from 1:2 to 1:1 but provided a stabilizing effect for Fe(V) intermediate formed in situ, enabling its degradation of SAs. Overall, the results of this study suggested that Fe(VI) is a promising oxidant for the removal of pharmaceuticals in hydrolyzed urine. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/30933490/Oxidation_of_Pharmaceuticals_by_Ferrate_VI__in_Hydrolyzed_Urine:_Effects_of_Major_Inorganic_Constituents_ DB - PRIME DP - Unbound Medicine ER -