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Harnessing CRISPR/Cas9 technology in cardiovascular disease.
Trends Cardiovasc Med. 2020 02; 30(2):93-101.TC

Abstract

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compared to other genome editing techniques such as zinc-finger nucleases and transcription activator-like effector nucleases (TALENS), the CRISPR/Cas9 system is much easier and more efficient. Most importantly, the multifunctional capacity of this technology allows simultaneous editing of several genes. The CRISPR/Cas9 system also potentially has the ability to prevent and treat human diseases. The present article addresses some key points related to the use of the CRISPR/Cas9 system as a powerful tool in cardiovascular research and as a new strategy for the treatment of cardiovascular disease (CVD).

Authors+Show Affiliations

Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.Departeman of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran.Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Biology, Faculty of basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.Departeman of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran.Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK.Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sahebkara@mums.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30935726

Citation

Rezaei, Hamzeh, et al. "Harnessing CRISPR/Cas9 Technology in Cardiovascular Disease." Trends in Cardiovascular Medicine, vol. 30, no. 2, 2020, pp. 93-101.
Rezaei H, Khadempar S, Farahani N, et al. Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends Cardiovasc Med. 2020;30(2):93-101.
Rezaei, H., Khadempar, S., Farahani, N., Hosseingholi, E. Z., Hayat, S. M. G., Sathyapalan, T., & Sahebkar, A. H. (2020). Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends in Cardiovascular Medicine, 30(2), 93-101. https://doi.org/10.1016/j.tcm.2019.03.005
Rezaei H, et al. Harnessing CRISPR/Cas9 Technology in Cardiovascular Disease. Trends Cardiovasc Med. 2020;30(2):93-101. PubMed PMID: 30935726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Harnessing CRISPR/Cas9 technology in cardiovascular disease. AU - Rezaei,Hamzeh, AU - Khadempar,Saedeh, AU - Farahani,Najmeh, AU - Hosseingholi,Elaheh Zadeh, AU - Hayat,Seyed Mohammad Gheibi, AU - Sathyapalan,Thozhukat, AU - Sahebkar,Amir Hossein, Y1 - 2019/03/26/ PY - 2018/12/30/received PY - 2019/03/03/revised PY - 2019/03/20/accepted PY - 2019/4/3/pubmed PY - 2020/10/21/medline PY - 2019/4/3/entrez KW - CRISPR/Cas9 KW - Cardiovascular disease KW - Genome editing SP - 93 EP - 101 JF - Trends in cardiovascular medicine JO - Trends Cardiovasc Med VL - 30 IS - 2 N2 - The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compared to other genome editing techniques such as zinc-finger nucleases and transcription activator-like effector nucleases (TALENS), the CRISPR/Cas9 system is much easier and more efficient. Most importantly, the multifunctional capacity of this technology allows simultaneous editing of several genes. The CRISPR/Cas9 system also potentially has the ability to prevent and treat human diseases. The present article addresses some key points related to the use of the CRISPR/Cas9 system as a powerful tool in cardiovascular research and as a new strategy for the treatment of cardiovascular disease (CVD). SN - 1873-2615 UR - https://www.unboundmedicine.com/medline/citation/30935726/Harnessing_CRISPR/Cas9_technology_in_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-1738(19)30042-8 DB - PRIME DP - Unbound Medicine ER -