Tags

Type your tag names separated by a space and hit enter

Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy.
Graefes Arch Clin Exp Ophthalmol. 2019 Jun; 257(6):1169-1181.GA

Abstract

PURPOSE

The purpose of the study was to investigate the characteristics of the parafoveal cone density changes in patients with retinitis pigmentosa (RP) using adaptive optics scanning laser ophthalmoscopy (AO-SLO).

METHODS

A total of 14 eyes of RP patients and 10 eyes of control subjects were examined. High-resolution images of cone photoreceptor cells were obtained with a Canon AO-SLO system in the four retinal regions of the superior, inferior, temporal, and nasal areas located 1.0 mm from the central fovea. The relationships of cone density with optical coherence tomography (OCT) findings and the visual sensitivity of the static perimetry tests were analyzed in RP patients.

RESULTS

The averaged cone densities in RP patients were decreased at 1.0 mm eccentricity from the fovea (11,899 cells/mm2) compared with those in control subjects (16,647 cells/mm2; P < 0.01). The cone density was substantially decreased even in RP patients with an intact interdigitation zone at the examined area (12,865 cells/mm2; P < 0.01 vs. controls) and preserved visual sensitivity with > 35 dB (13,019 cells/mm2; P < 0.001 vs. controls).

CONCLUSIONS

In RP, cone photoreceptor cell loss occurred in the parafoveal region with a preserved EZ/IZ or visual sensitivity. AO-SLO may be a useful modality to detect early changes of cone photoreceptor cells in RP patients.

Authors+Show Affiliations

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan. ymuraka3@med.kyushu-u.ac.jp.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30937533

Citation

Nakatake, Shunji, et al. "Early Detection of Cone Photoreceptor Cell Loss in Retinitis Pigmentosa Using Adaptive Optics Scanning Laser Ophthalmoscopy." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 257, no. 6, 2019, pp. 1169-1181.
Nakatake S, Murakami Y, Funatsu J, et al. Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy. Graefes Arch Clin Exp Ophthalmol. 2019;257(6):1169-1181.
Nakatake, S., Murakami, Y., Funatsu, J., Koyanagi, Y., Akiyama, M., Momozawa, Y., Ishibashi, T., Sonoda, K. H., & Ikeda, Y. (2019). Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 257(6), 1169-1181. https://doi.org/10.1007/s00417-019-04307-0
Nakatake S, et al. Early Detection of Cone Photoreceptor Cell Loss in Retinitis Pigmentosa Using Adaptive Optics Scanning Laser Ophthalmoscopy. Graefes Arch Clin Exp Ophthalmol. 2019;257(6):1169-1181. PubMed PMID: 30937533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy. AU - Nakatake,Shunji, AU - Murakami,Yusuke, AU - Funatsu,Jun, AU - Koyanagi,Yoshito, AU - Akiyama,Masato, AU - Momozawa,Yukihide, AU - Ishibashi,Tatsuro, AU - Sonoda,Koh-Hei, AU - Ikeda,Yasuhiro, Y1 - 2019/04/01/ PY - 2018/10/27/received PY - 2019/03/21/accepted PY - 2019/02/18/revised PY - 2019/4/3/pubmed PY - 2019/6/6/medline PY - 2019/4/3/entrez KW - Adaptive optics scanning laser ophthalmoscopy (AO-SLO) KW - Cone density KW - Cone photoreceptor cell KW - Retinitis pigmentosa SP - 1169 EP - 1181 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 257 IS - 6 N2 - PURPOSE: The purpose of the study was to investigate the characteristics of the parafoveal cone density changes in patients with retinitis pigmentosa (RP) using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS: A total of 14 eyes of RP patients and 10 eyes of control subjects were examined. High-resolution images of cone photoreceptor cells were obtained with a Canon AO-SLO system in the four retinal regions of the superior, inferior, temporal, and nasal areas located 1.0 mm from the central fovea. The relationships of cone density with optical coherence tomography (OCT) findings and the visual sensitivity of the static perimetry tests were analyzed in RP patients. RESULTS: The averaged cone densities in RP patients were decreased at 1.0 mm eccentricity from the fovea (11,899 cells/mm2) compared with those in control subjects (16,647 cells/mm2; P < 0.01). The cone density was substantially decreased even in RP patients with an intact interdigitation zone at the examined area (12,865 cells/mm2; P < 0.01 vs. controls) and preserved visual sensitivity with > 35 dB (13,019 cells/mm2; P < 0.001 vs. controls). CONCLUSIONS: In RP, cone photoreceptor cell loss occurred in the parafoveal region with a preserved EZ/IZ or visual sensitivity. AO-SLO may be a useful modality to detect early changes of cone photoreceptor cells in RP patients. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/30937533/Early_detection_of_cone_photoreceptor_cell_loss_in_retinitis_pigmentosa_using_adaptive_optics_scanning_laser_ophthalmoscopy_ L2 - https://dx.doi.org/10.1007/s00417-019-04307-0 DB - PRIME DP - Unbound Medicine ER -