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Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus.
Mov Disord. 2019 06; 34(6):884-892.MD

Abstract

BACKGROUND

We aimed to investigate neuromelanin-sensitive magnetic resonance imaging (NM-MRI) features in the locus coeruleus of de novo Parkinson's disease patients with different cognitive states and to determine whether these features are associated with cognitive impairment.

METHODS

Three groups of subjects were recruited in this study, including patients with de novo PD with mild cognitive impairment (n = 23), patients with de novo PD without cognitive impairment (n = 48), and control subjects (n = 32). All subjects underwent clinical evaluations, as well as MRI scanning. The contrast-to-noise ratio of the locus coeruleus in the neuromelanin-sensitive MRI images and cortical thickness were measured.

RESULTS

The contrast-to-noise ratio of the locus coeruleus in PD patients with mild cognitive impairment was significantly lower than that of controls (P = 0.016). The contrast-to-noise ratio of the locus coeruleus for PD patients without cognitive impairment was intermediate between that of controls and PD patients with mild cognitive impairment. Furthermore, multiple linear regression analysis showed that the contrast-to-noise ratio of the locus coeruleus was negatively associated with performance on the Trail Making Test B in all PD patients, controlling for age, sex, years of education, the Unified Parkinson's Disease Rating Scale motor scores from right upper limb, Geriatric Depression Rating Scales scores, Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire scores, and cortical thickness.

CONCLUSIONS

Dysfunction of the locus coeruleus neurons may partly contribute to the decline in executive function in early de novo PD. In the future, the locus coeruleus-norepinephrine system might be targeted for early-intervention strategies in PD patients. © 2019 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. Shanghai Medical Imaging Institute, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. Shanghai Medical Imaging Institute, Shanghai, China.MR Research, GE Healthcare, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. Shanghai Medical Imaging Institute, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China. Shanghai Medical Imaging Institute, Shanghai, China.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30938892

Citation

Li, Yuanfang, et al. "Mild Cognitive Impairment in De Novo Parkinson's Disease: a Neuromelanin MRI Study in Locus Coeruleus." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 34, no. 6, 2019, pp. 884-892.
Li Y, Wang C, Wang J, et al. Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus. Mov Disord. 2019;34(6):884-892.
Li, Y., Wang, C., Wang, J., Zhou, Y., Ye, F., Zhang, Y., Cheng, X., Huang, Z., Liu, K., Fei, G., Zhong, C., Zeng, M., & Jin, L. (2019). Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus. Movement Disorders : Official Journal of the Movement Disorder Society, 34(6), 884-892. https://doi.org/10.1002/mds.27682
Li Y, et al. Mild Cognitive Impairment in De Novo Parkinson's Disease: a Neuromelanin MRI Study in Locus Coeruleus. Mov Disord. 2019;34(6):884-892. PubMed PMID: 30938892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus. AU - Li,Yuanfang, AU - Wang,Changpeng, AU - Wang,Jian, AU - Zhou,Ying, AU - Ye,Fang, AU - Zhang,Yong, AU - Cheng,Xiaoqin, AU - Huang,Zhen, AU - Liu,Kai, AU - Fei,Guoqiang, AU - Zhong,Chunjiu, AU - Zeng,Mengsu, AU - Jin,Lirong, Y1 - 2019/04/02/ PY - 2018/07/08/received PY - 2019/02/15/revised PY - 2019/02/18/accepted PY - 2019/4/3/pubmed PY - 2020/3/14/medline PY - 2019/4/3/entrez KW - MRI KW - Parkinson's disease KW - locus coeruleus KW - mild cognitive impairment KW - neuromelanin SP - 884 EP - 892 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 34 IS - 6 N2 - BACKGROUND: We aimed to investigate neuromelanin-sensitive magnetic resonance imaging (NM-MRI) features in the locus coeruleus of de novo Parkinson's disease patients with different cognitive states and to determine whether these features are associated with cognitive impairment. METHODS: Three groups of subjects were recruited in this study, including patients with de novo PD with mild cognitive impairment (n = 23), patients with de novo PD without cognitive impairment (n = 48), and control subjects (n = 32). All subjects underwent clinical evaluations, as well as MRI scanning. The contrast-to-noise ratio of the locus coeruleus in the neuromelanin-sensitive MRI images and cortical thickness were measured. RESULTS: The contrast-to-noise ratio of the locus coeruleus in PD patients with mild cognitive impairment was significantly lower than that of controls (P = 0.016). The contrast-to-noise ratio of the locus coeruleus for PD patients without cognitive impairment was intermediate between that of controls and PD patients with mild cognitive impairment. Furthermore, multiple linear regression analysis showed that the contrast-to-noise ratio of the locus coeruleus was negatively associated with performance on the Trail Making Test B in all PD patients, controlling for age, sex, years of education, the Unified Parkinson's Disease Rating Scale motor scores from right upper limb, Geriatric Depression Rating Scales scores, Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire scores, and cortical thickness. CONCLUSIONS: Dysfunction of the locus coeruleus neurons may partly contribute to the decline in executive function in early de novo PD. In the future, the locus coeruleus-norepinephrine system might be targeted for early-intervention strategies in PD patients. © 2019 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/30938892/Mild_cognitive_impairment_in_de_novo_Parkinson's_disease:_A_neuromelanin_MRI_study_in_locus_coeruleus_ L2 - https://doi.org/10.1002/mds.27682 DB - PRIME DP - Unbound Medicine ER -