Tags

Type your tag names separated by a space and hit enter

Immune-mediated necrotizing myopathy due to statins exposure.
Acta Myol. 2018 Dec; 37(4):257-262.AM

Abstract

Statin-induced necrotizing autoimmune myopathy (IMNM) is an autoimmune disorder induced by anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase (anti-HMGCR) antibodies. We performed a retrospective clinical, histological, and radiological evaluation of 5 patients with a 3-year therapeutic follow-up. All patients used statins and then experienced proximal weakness that persisted after drug cessation. Muscle biopsies revealed a primary necrotizing myopathy without inflammatory infiltrates. All patients required immunomodulant combination therapy to achieve clinical remission. Magnetic resonance imaging (MRI) showed the presence of edema in the medial gastrocnemius, posterior and central loggia of the thigh, posterior loggia of the arm, and the infraspinatus and subscapularis muscles, as well as extensive inflammation of the subcutaneous tissues and muscolaris fasciae. Serum analysis, muscle biopsy, and MRI are fundamental for IMNM diagnosis and follow-up. The growing use of statins in the general population raises the importance of acquaintance with this disease in clinical practice.

Authors+Show Affiliations

Neuromuscular and Rare Disease Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy. Neuromuscular Disease Centre, Department of Clinical Neurosciences, University Hospital of Nice (CHU), France.Neuromuscular and Rare Disease Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy.Neuroradiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy.Neuromuscular and Rare Disease Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy.Laboratorio analisi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Laboratorio analisi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Laboratorio analisi, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Neuromuscular and Rare Disease Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy.Neuromuscular and Rare Disease Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy.Neuromuscular and Rare Disease Unit, Department of Neuroscience, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Italy.Neuroradiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy.Neuroradiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30944904

Citation

Villa, Luisa, et al. "Immune-mediated Necrotizing Myopathy Due to Statins Exposure." Acta Myologica : Myopathies and Cardiomyopathies : Official Journal of the Mediterranean Society of Myology, vol. 37, no. 4, 2018, pp. 257-262.
Villa L, Lerario A, Calloni S, et al. Immune-mediated necrotizing myopathy due to statins exposure. Acta Myol. 2018;37(4):257-262.
Villa, L., Lerario, A., Calloni, S., Peverelli, L., Matinato, C., DE Liso, F., Ceriotti, F., Tironi, R., Sciacco, M., Moggio, M., Triulzi, F., & Cinnante, C. (2018). Immune-mediated necrotizing myopathy due to statins exposure. Acta Myologica : Myopathies and Cardiomyopathies : Official Journal of the Mediterranean Society of Myology, 37(4), 257-262.
Villa L, et al. Immune-mediated Necrotizing Myopathy Due to Statins Exposure. Acta Myol. 2018;37(4):257-262. PubMed PMID: 30944904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune-mediated necrotizing myopathy due to statins exposure. AU - Villa,Luisa, AU - Lerario,Alberto, AU - Calloni,Sonia, AU - Peverelli,Lorenzo, AU - Matinato,Caterina, AU - DE Liso,Federica, AU - Ceriotti,Ferruccio, AU - Tironi,Roberto, AU - Sciacco,Monica, AU - Moggio,Maurizio, AU - Triulzi,Fabio, AU - Cinnante,Claudia, Y1 - 2018/12/01/ PY - 2019/4/5/entrez PY - 2019/4/5/pubmed PY - 2019/8/9/medline KW - HMGCR autoantibodies KW - muscular MRI KW - necrotizing myopathy SP - 257 EP - 262 JF - Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology JO - Acta Myol VL - 37 IS - 4 N2 - Statin-induced necrotizing autoimmune myopathy (IMNM) is an autoimmune disorder induced by anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase (anti-HMGCR) antibodies. We performed a retrospective clinical, histological, and radiological evaluation of 5 patients with a 3-year therapeutic follow-up. All patients used statins and then experienced proximal weakness that persisted after drug cessation. Muscle biopsies revealed a primary necrotizing myopathy without inflammatory infiltrates. All patients required immunomodulant combination therapy to achieve clinical remission. Magnetic resonance imaging (MRI) showed the presence of edema in the medial gastrocnemius, posterior and central loggia of the thigh, posterior loggia of the arm, and the infraspinatus and subscapularis muscles, as well as extensive inflammation of the subcutaneous tissues and muscolaris fasciae. Serum analysis, muscle biopsy, and MRI are fundamental for IMNM diagnosis and follow-up. The growing use of statins in the general population raises the importance of acquaintance with this disease in clinical practice. SN - 2532-1900 UR - https://www.unboundmedicine.com/medline/citation/30944904/Immune_mediated_necrotizing_myopathy_due_to_statins_exposure_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30944904/ DB - PRIME DP - Unbound Medicine ER -