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Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review.
Curr Pharm Des. 2019; 25(8):871-935.CP

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The genus Curcuma, which is the most important source of curcumin, has been widely used in different traditional medicines. Various species of Curcuma have long been used for several purposes such as healing wounds, liver disorders, jaundice and also as a blood purifier.

AIM OF THE STUDY

This review focused on the ethnopharmacological uses and phytochemical aspects of Curcuma. Additionally, in this study, the different properties of two species of Curcuma in Islamic Traditional Medicine (ITM), C. longa and C. zedoaria, as well as their pharmacological aspects in modern medicine are reviewed.

MATERIALS AND METHODS

ITM literatures were searched to find Curcuma's applications. Also, electronic databases including PubMed and Scopus were searched to obtain studies giving any in vitro, in vivo or human evidence of the efficacy of C. longa and C. zedoaria in the treatment of different diseases. ChemOffice software was used to find chemical structures.

RESULTS

The analysis showed that ethno-medical uses of Curcuma have been recorded for centuries. Approximately, 427 chemical compounds have been isolated and identified from Curcuma spp. This genus is rich in flavonoids, tannins, anthocyanin, phenolic compounds, oil, organic acids and inorganic compounds. Curcumin is one of the main active ingredients in Curcuma which has strong anti-inflammatory and antioxidant effects. Besides, pharmacological studies have indicated wide range of Curcuma's activities, such as hepato-protective, antifungal, antihypertensive and neuroprotective.

CONCLUSIONS

In this study, we reviewed various studies conducted on ethno-medicinal, ITM properties and photochemistry of Curcuma spp. Also, pharmacological activities of two species, C. longa and C. zedoaria are summarized. Pre-clinical investigations have demonstrated some of the traditional aspects of Curcuma, such as wound healing, anti-arthritic, anti-tumor and liver protective activities. These could be related to antioxidant and anti-inflammatory properties of Curcuma which might be due to high amounts of phenolic compounds. Curcuma is mentioned to have neural tonic properties in ITM which have been confirmed by some animal studies. Considering various preclinical studies on C. longa and C. zedoaria and their active ingredient, curcumin, randomized controlled trials are warranted to confirm their promise as a clinically effective hepato and neuro-protective agents.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ayati Z
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Ramezani M
Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amiri MS
Department of Biology, Payame Noor University, Tehran, Iran.
Moghadam AT
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rahimi H
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abdollahzade A
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Sahebkar A
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Emami SA
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmacognosy, School of Pharmacy, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

MeSH

AnimalsCurcumaEthnobotanyEthnopharmacologyHumansMedicine, TraditionalPhytochemicalsPhytotherapyPlant Extracts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30947655

Citation

Ayati, Zahra, et al. "Ethnobotany, Phytochemistry and Traditional Uses of Curcuma Spp. and Pharmacological Profile of Two Important Species (C. Longa and C. Zedoaria): a Review." Current Pharmaceutical Design, vol. 25, no. 8, 2019, pp. 871-935.
Ayati Z, Ramezani M, Amiri MS, et al. Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review. Curr Pharm Des. 2019;25(8):871-935.
Ayati, Z., Ramezani, M., Amiri, M. S., Moghadam, A. T., Rahimi, H., Abdollahzade, A., Sahebkar, A., & Emami, S. A. (2019). Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review. Current Pharmaceutical Design, 25(8), 871-935. https://doi.org/10.2174/1381612825666190402163940
Ayati Z, et al. Ethnobotany, Phytochemistry and Traditional Uses of Curcuma Spp. and Pharmacological Profile of Two Important Species (C. Longa and C. Zedoaria): a Review. Curr Pharm Des. 2019;25(8):871-935. PubMed PMID: 30947655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnobotany, Phytochemistry and Traditional Uses of Curcuma spp. and Pharmacological Profile of Two Important Species (C. longa and C. zedoaria): A Review. AU - Ayati,Zahra, AU - Ramezani,Mahin, AU - Amiri,Mohammad Sadegh, AU - Moghadam,Ali Tafazoli, AU - Rahimi,Hoda, AU - Abdollahzade,Aref, AU - Sahebkar,Amirhossein, AU - Emami,Seyed Ahmad, PY - 2018/12/12/received PY - 2019/03/26/accepted PY - 2019/4/6/pubmed PY - 2020/2/25/medline PY - 2019/4/6/entrez KW - Curcuma KW - Curcuma longa KW - Curcuma zedoaria KW - Zingiberaceae KW - curcumin KW - liver protection KW - turmeric. SP - 871 EP - 935 JF - Current pharmaceutical design JO - Curr Pharm Des VL - 25 IS - 8 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The genus Curcuma, which is the most important source of curcumin, has been widely used in different traditional medicines. Various species of Curcuma have long been used for several purposes such as healing wounds, liver disorders, jaundice and also as a blood purifier. AIM OF THE STUDY: This review focused on the ethnopharmacological uses and phytochemical aspects of Curcuma. Additionally, in this study, the different properties of two species of Curcuma in Islamic Traditional Medicine (ITM), C. longa and C. zedoaria, as well as their pharmacological aspects in modern medicine are reviewed. MATERIALS AND METHODS: ITM literatures were searched to find Curcuma's applications. Also, electronic databases including PubMed and Scopus were searched to obtain studies giving any in vitro, in vivo or human evidence of the efficacy of C. longa and C. zedoaria in the treatment of different diseases. ChemOffice software was used to find chemical structures. RESULTS: The analysis showed that ethno-medical uses of Curcuma have been recorded for centuries. Approximately, 427 chemical compounds have been isolated and identified from Curcuma spp. This genus is rich in flavonoids, tannins, anthocyanin, phenolic compounds, oil, organic acids and inorganic compounds. Curcumin is one of the main active ingredients in Curcuma which has strong anti-inflammatory and antioxidant effects. Besides, pharmacological studies have indicated wide range of Curcuma's activities, such as hepato-protective, antifungal, antihypertensive and neuroprotective. CONCLUSIONS: In this study, we reviewed various studies conducted on ethno-medicinal, ITM properties and photochemistry of Curcuma spp. Also, pharmacological activities of two species, C. longa and C. zedoaria are summarized. Pre-clinical investigations have demonstrated some of the traditional aspects of Curcuma, such as wound healing, anti-arthritic, anti-tumor and liver protective activities. These could be related to antioxidant and anti-inflammatory properties of Curcuma which might be due to high amounts of phenolic compounds. Curcuma is mentioned to have neural tonic properties in ITM which have been confirmed by some animal studies. Considering various preclinical studies on C. longa and C. zedoaria and their active ingredient, curcumin, randomized controlled trials are warranted to confirm their promise as a clinically effective hepato and neuro-protective agents. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/30947655/Ethnobotany_Phytochemistry_and_Traditional_Uses_of_Curcuma_spp__and_Pharmacological_Profile_of_Two_Important_Species__C__longa_and_C__zedoaria_:_A_Review_ DB - PRIME DP - Unbound Medicine ER -