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Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial.
J Nephrol. 2019 Aug; 32(4):581-587.JN

Abstract

BACKGROUND

Pentoxifylline could reduce proteinuria and slow renal disease progression. We previously conducted a single-blind, randomized, controlled trial that showed that pentoxifylline decreases inflammatory markers and stabilizes renal function.

SETTING AND PARTICIPANTS

91 participants (46 in the pentoxifylline group and 45 in the control group) followed up for 7 additional years.

STUDY DESIGN

Post hoc analysis of a long-term follow-up after completion of the 12-months trial.

INTERVENTION

Pentoxifylline treatment (400 mg/twice a day) or standard treatment.

OUTCOME

Renal event (defined as starting dialysis therapy and/or doubling serum creatinine and/or ≥ 50% decrease in estimated glomerular filtration rate) and cardiovascular mortality.

RESULTS

During follow-up, a renal event was recorded in 24 patients from control group (13 initiated dialysis therapy and serum creatinine doubled in 11) and 11 patients from PTF group (7 initiated dialysis and serum creatinine doubled in 4) (log Rank: 5.822, p = 0.016). The possible protector effect of PTF was more significant in albuminuric patients and was independently of diabetes mellitus presence. Treatment with PTF reduced the renal events by 35% compared to the control group in a Cox model adjusted for diabetes mellitus, albuminuria and basal renal function (HR 0.65 (0.45-0.94), p = 0.022). Cardiovascular mortality was significantly reduced in PTF treatment (2 patients vs. 10 in control group) (log Rank 5.0977, p = 0.024). PTF treatment reduced cardiovascular mortality in 55% adjusted for diabetes mellitus and age (HR 0.45 (0.21-0.98), p = 0.044) (Table 3).

LIMITATIONS

Small sample size, single center, not double blind and post hoc follow-up analysis.

CONCLUSIONS

Long-term treatment with pentoxifylline may slow the rate of progression of kidney disease and reduce cardiovascular risk.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

de Morales AM
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.
Goicoechea M
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain. marian.goicoechea@gmail.com. Spanish Kidney Research Network (REDINREN), FEDER FUND, Madrid, Spain. marian.goicoechea@gmail.com.
Verde E
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.
Carbayo J
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.
Barbieri D
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.
Delgado A
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain. Spanish Kidney Research Network (REDINREN), FEDER FUND, Madrid, Spain.
Verdalles U
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.
de Jose AP
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.
Luño J
Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain. Spanish Kidney Research Network (REDINREN), FEDER FUND, Madrid, Spain.

MeSH

AgedAged, 80 and overAlbuminuriaCardiovascular DiseasesCreatinineDisease ProgressionFollow-Up StudiesGlomerular Filtration RateHumansMiddle AgedPentoxifyllinePhosphodiesterase InhibitorsRenal DialysisRenal Insufficiency, ChronicSingle-Blind MethodTime Factors

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30949987

Citation

de Morales, Alejandra Muñoz, et al. "Pentoxifylline, Progression of Chronic Kidney Disease (CKD) and Cardiovascular Mortality: Long-term Follow-up of a Randomized Clinical Trial." Journal of Nephrology, vol. 32, no. 4, 2019, pp. 581-587.
de Morales AM, Goicoechea M, Verde E, et al. Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial. J Nephrol. 2019;32(4):581-587.
de Morales, A. M., Goicoechea, M., Verde, E., Carbayo, J., Barbieri, D., Delgado, A., Verdalles, U., de Jose, A. P., & Luño, J. (2019). Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial. Journal of Nephrology, 32(4), 581-587. https://doi.org/10.1007/s40620-019-00607-0
de Morales AM, et al. Pentoxifylline, Progression of Chronic Kidney Disease (CKD) and Cardiovascular Mortality: Long-term Follow-up of a Randomized Clinical Trial. J Nephrol. 2019;32(4):581-587. PubMed PMID: 30949987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial. AU - de Morales,Alejandra Muñoz, AU - Goicoechea,Marian, AU - Verde,Eduardo, AU - Carbayo,Javier, AU - Barbieri,Diego, AU - Delgado,Andrés, AU - Verdalles,Ursula, AU - de Jose,Ana Perez, AU - Luño,José, Y1 - 2019/04/04/ PY - 2019/02/28/received PY - 2019/03/29/accepted PY - 2019/4/6/pubmed PY - 2020/8/19/medline PY - 2019/4/6/entrez KW - Pentoxifylline-chronic kidney disease-cardiovascular mortality SP - 581 EP - 587 JF - Journal of nephrology JO - J Nephrol VL - 32 IS - 4 N2 - BACKGROUND: Pentoxifylline could reduce proteinuria and slow renal disease progression. We previously conducted a single-blind, randomized, controlled trial that showed that pentoxifylline decreases inflammatory markers and stabilizes renal function. SETTING AND PARTICIPANTS: 91 participants (46 in the pentoxifylline group and 45 in the control group) followed up for 7 additional years. STUDY DESIGN: Post hoc analysis of a long-term follow-up after completion of the 12-months trial. INTERVENTION: Pentoxifylline treatment (400 mg/twice a day) or standard treatment. OUTCOME: Renal event (defined as starting dialysis therapy and/or doubling serum creatinine and/or ≥ 50% decrease in estimated glomerular filtration rate) and cardiovascular mortality. RESULTS: During follow-up, a renal event was recorded in 24 patients from control group (13 initiated dialysis therapy and serum creatinine doubled in 11) and 11 patients from PTF group (7 initiated dialysis and serum creatinine doubled in 4) (log Rank: 5.822, p = 0.016). The possible protector effect of PTF was more significant in albuminuric patients and was independently of diabetes mellitus presence. Treatment with PTF reduced the renal events by 35% compared to the control group in a Cox model adjusted for diabetes mellitus, albuminuria and basal renal function (HR 0.65 (0.45-0.94), p = 0.022). Cardiovascular mortality was significantly reduced in PTF treatment (2 patients vs. 10 in control group) (log Rank 5.0977, p = 0.024). PTF treatment reduced cardiovascular mortality in 55% adjusted for diabetes mellitus and age (HR 0.45 (0.21-0.98), p = 0.044) (Table 3). LIMITATIONS: Small sample size, single center, not double blind and post hoc follow-up analysis. CONCLUSIONS: Long-term treatment with pentoxifylline may slow the rate of progression of kidney disease and reduce cardiovascular risk. SN - 1724-6059 UR - https://www.unboundmedicine.com/medline/citation/30949987/Pentoxifylline_progression_of_chronic_kidney_disease__CKD__and_cardiovascular_mortality:_long_term_follow_up_of_a_randomized_clinical_trial_ DB - PRIME DP - Unbound Medicine ER -