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Genome-wide Association Mapping and Prediction of Adult Stage Septoria tritici Blotch Infection in European Winter Wheat via High-Density Marker Arrays.
Plant Genome. 2019 03; 12(1)PG

Abstract

blotch (STB) caused by the fungus is a devastating foliar disease of wheat (L.) that can lead to substantial yield losses. Quantitative genetic resistance has been proposed as a durable strategy for STB control. In this study, we dissected the genetic basis of STB infection in 371 European wheat varieties based on 35k and 90k single nucleotide polymorphism marker arrays. The phenotypic data analyses suggested that large genetic variance exists for STB infection with a broad-sense heritability of 0.78. Genome-wide association studies (GWAS) propose the highly quantitative nature of STB infection with potential associations on chromosomes 1A, 1B, 2D, 4A, 5A, 6A, 6D, 7A, and 7B. Increased marker density in GWAS by combining markers from both arrays helped to detect additional markers explaining increased genotypic variance. Linkage disequilibrium analyses revealed genes with a possible role in disease resistance. The potential of genomic prediction (GP) assessed via two models accounting for additive effects and additive plus epistatic interactions among the loci suggested the possibility of genomic selection for improved STB resistance. Genomic prediction results also indicated that the higher-order epistatic interactions are not abundant and that both marker platforms are equally suitable for GP of STB infection. Our results provide further understanding of the quantitative genetic nature of STB infection, serve as a resource for marker-assisted breeding, and highlight the potential of genomic selection for improved STB resistance.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30951099

Citation

Muqaddasi, Quddoos H., et al. "Genome-wide Association Mapping and Prediction of Adult Stage Septoria Tritici Blotch Infection in European Winter Wheat Via High-Density Marker Arrays." The Plant Genome, vol. 12, no. 1, 2019.
Muqaddasi QH, Zhao Y, Rodemann B, et al. Genome-wide Association Mapping and Prediction of Adult Stage Septoria tritici Blotch Infection in European Winter Wheat via High-Density Marker Arrays. Plant Genome. 2019;12(1).
Muqaddasi, Q. H., Zhao, Y., Rodemann, B., Plieske, J., Ganal, M. W., & Röder, M. S. (2019). Genome-wide Association Mapping and Prediction of Adult Stage Septoria tritici Blotch Infection in European Winter Wheat via High-Density Marker Arrays. The Plant Genome, 12(1). https://doi.org/10.3835/plantgenome2018.05.0029
Muqaddasi QH, et al. Genome-wide Association Mapping and Prediction of Adult Stage Septoria Tritici Blotch Infection in European Winter Wheat Via High-Density Marker Arrays. Plant Genome. 2019;12(1) PubMed PMID: 30951099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome-wide Association Mapping and Prediction of Adult Stage Septoria tritici Blotch Infection in European Winter Wheat via High-Density Marker Arrays. AU - Muqaddasi,Quddoos H, AU - Zhao,Yusheng, AU - Rodemann,Bernd, AU - Plieske,Jörg, AU - Ganal,Martin W, AU - Röder,Marion S, PY - 2019/4/6/entrez PY - 2019/4/6/pubmed PY - 2019/4/24/medline JF - The plant genome JO - Plant Genome VL - 12 IS - 1 N2 - blotch (STB) caused by the fungus is a devastating foliar disease of wheat (L.) that can lead to substantial yield losses. Quantitative genetic resistance has been proposed as a durable strategy for STB control. In this study, we dissected the genetic basis of STB infection in 371 European wheat varieties based on 35k and 90k single nucleotide polymorphism marker arrays. The phenotypic data analyses suggested that large genetic variance exists for STB infection with a broad-sense heritability of 0.78. Genome-wide association studies (GWAS) propose the highly quantitative nature of STB infection with potential associations on chromosomes 1A, 1B, 2D, 4A, 5A, 6A, 6D, 7A, and 7B. Increased marker density in GWAS by combining markers from both arrays helped to detect additional markers explaining increased genotypic variance. Linkage disequilibrium analyses revealed genes with a possible role in disease resistance. The potential of genomic prediction (GP) assessed via two models accounting for additive effects and additive plus epistatic interactions among the loci suggested the possibility of genomic selection for improved STB resistance. Genomic prediction results also indicated that the higher-order epistatic interactions are not abundant and that both marker platforms are equally suitable for GP of STB infection. Our results provide further understanding of the quantitative genetic nature of STB infection, serve as a resource for marker-assisted breeding, and highlight the potential of genomic selection for improved STB resistance. SN - 1940-3372 UR - https://www.unboundmedicine.com/medline/citation/30951099/Genome_wide_Association_Mapping_and_Prediction_of_Adult_Stage_Septoria_tritici_Blotch_Infection_in_European_Winter_Wheat_via_High_Density_Marker_Arrays_ L2 - https://doi.org/10.3835/plantgenome2018.05.0029 DB - PRIME DP - Unbound Medicine ER -