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Maternal multivitamin supplementation is associated with a reduced risk of autism spectrum disorder in children: a systematic review and meta-analysis.
Nutr Res. 2019 05; 65:4-16.NR

Abstract

Several studies have explored the link of antenatal multivitamin supplementation with autism spectrum disorder (ASD) in offspring, but the findings are inconsistent. The purpose of the current study was to perform a systematic review and meta-analysis of published studies to evaluate the actual association between maternal multivitamin supplementation during the prenatal period and the risk of ASD in children. PubMed, EMBASE, PsycINFO, Web of Science, and Cochrane Library were searched up to August 26, 2018. The random-effects model was used to calculate the pooled results. The adjusted risk ratios (RRs) were used as the common measure of association among studies. Sensitivity and subgroup analyses were also conducted. A total of 5 articles (9 independent trials; 231 163 children encompassing 4459 cases) were included. The results of overall analysis showed that the likelihood of ASD in offspring whose mothers used multivitamin supplements during the prenatal period was significantly reduced compared with that in offspring of mothers without such supplementation (RR, 0.62; 95% CI, 0.45-0.86; P = .003). Additionally, the primary outcome of the meta-analysis was quite robust after being verified by sensitivity analyses and no publication bias was found. Furthermore, the findings of overall analysis were generally consistent with those of subgroup analyses. In conclusion, this meta-analysis supports a protective association between maternal multivitamin supplementation during the prenatal period and the subsequent risk of ASD in children. Further investigation is needed and should address the constituent(s) contributing to the protective effect of multivitamin on ASD risk and the underlying molecular mechanisms.

Authors+Show Affiliations

Department of Child and Adolescent Health, School of Public Health, Xinxiang Medical University, Xinxiang, Henan 453003, China. Electronic address: 161006@xxmu.edu.cn.Department of Child and Adolescent Health, School of Public Health, Xinxiang Medical University, Xinxiang, Henan 453003, China.Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan 453003, China.Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

30952506

Citation

Guo, Bao-Qiang, et al. "Maternal Multivitamin Supplementation Is Associated With a Reduced Risk of Autism Spectrum Disorder in Children: a Systematic Review and Meta-analysis." Nutrition Research (New York, N.Y.), vol. 65, 2019, pp. 4-16.
Guo BQ, Li HB, Zhai DS, et al. Maternal multivitamin supplementation is associated with a reduced risk of autism spectrum disorder in children: a systematic review and meta-analysis. Nutr Res. 2019;65:4-16.
Guo, B. Q., Li, H. B., Zhai, D. S., & Ding, S. B. (2019). Maternal multivitamin supplementation is associated with a reduced risk of autism spectrum disorder in children: a systematic review and meta-analysis. Nutrition Research (New York, N.Y.), 65, 4-16. https://doi.org/10.1016/j.nutres.2019.02.003
Guo BQ, et al. Maternal Multivitamin Supplementation Is Associated With a Reduced Risk of Autism Spectrum Disorder in Children: a Systematic Review and Meta-analysis. Nutr Res. 2019;65:4-16. PubMed PMID: 30952506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal multivitamin supplementation is associated with a reduced risk of autism spectrum disorder in children: a systematic review and meta-analysis. AU - Guo,Bao-Qiang, AU - Li,Hong-Bin, AU - Zhai,De-Sheng, AU - Ding,Shi-Bin, Y1 - 2019/02/24/ PY - 2018/10/23/received PY - 2019/01/26/revised PY - 2019/02/15/accepted PY - 2019/4/7/pubmed PY - 2020/7/25/medline PY - 2019/4/7/entrez KW - Autism spectrum disorder KW - Children KW - Meta-analysis KW - Multivitamin supplementation KW - Prenatal period SP - 4 EP - 16 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 65 N2 - Several studies have explored the link of antenatal multivitamin supplementation with autism spectrum disorder (ASD) in offspring, but the findings are inconsistent. The purpose of the current study was to perform a systematic review and meta-analysis of published studies to evaluate the actual association between maternal multivitamin supplementation during the prenatal period and the risk of ASD in children. PubMed, EMBASE, PsycINFO, Web of Science, and Cochrane Library were searched up to August 26, 2018. The random-effects model was used to calculate the pooled results. The adjusted risk ratios (RRs) were used as the common measure of association among studies. Sensitivity and subgroup analyses were also conducted. A total of 5 articles (9 independent trials; 231 163 children encompassing 4459 cases) were included. The results of overall analysis showed that the likelihood of ASD in offspring whose mothers used multivitamin supplements during the prenatal period was significantly reduced compared with that in offspring of mothers without such supplementation (RR, 0.62; 95% CI, 0.45-0.86; P = .003). Additionally, the primary outcome of the meta-analysis was quite robust after being verified by sensitivity analyses and no publication bias was found. Furthermore, the findings of overall analysis were generally consistent with those of subgroup analyses. In conclusion, this meta-analysis supports a protective association between maternal multivitamin supplementation during the prenatal period and the subsequent risk of ASD in children. Further investigation is needed and should address the constituent(s) contributing to the protective effect of multivitamin on ASD risk and the underlying molecular mechanisms. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/30952506/Maternal_multivitamin_supplementation_is_associated_with_a_reduced_risk_of_autism_spectrum_disorder_in_children:_a_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(18)31203-X DB - PRIME DP - Unbound Medicine ER -