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Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.
J Am Acad Dermatol. 2019 Aug; 81(2):480-488.JA

Abstract

BACKGROUND

Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, and in another form, skin appears thickened with coarse wrinkles. Etiologic, clinical, and therapeutic distinctions among different forms of photoaging remain largely unknown.

OBJECTIVE

To characterize the clinical, histologic, and molecular features of hypertrophic and atrophic photoaging.

METHODS

In total, 53 individuals were clinically classified as having primarily atrophic or hypertrophic photoaging or neither (controls). Participants' demographic and sun exposure-related lifestyle data were captured by questionnaire. Fifteen clinical features of participants were qualitatively or quantitively scored. Facial biopsies were analyzed for gene expression and histologic characteristics.

RESULTS

Actinic and seborrheic keratosis, telangiectasia, and prior incidence of skin cancers were statistically significantly greater and photoaging scale severity, coarse wrinkles, thickness, and sallowness were significantly reduced in atrophic versus hypertrophic groups. Histology also revealed significantly less elastotic material in atrophic photoaging. Gene expression of matrix metalloproteinases and collagens did not differ between the 2 forms of photoaging.

LIMITATIONS

The study was not designed to identify other possible subtypes of photoaging.

CONCLUSION

Systematic, categorical, and quantitative clinical and histologic assessments distinguish atrophic and hypertrophic photoaging.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Dermatology, University of Michigan, Ann Arbor, Michigan. Electronic address: dsachs@med.umich.edu.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

Pub Type(s)

Journal Article

Observational Study

Language

eng

PubMed ID

30954583

Citation

Sachs, Dana L., et al. "Atrophic and Hypertrophic Photoaging: Clinical, Histologic, and Molecular Features of 2 Distinct Phenotypes of Photoaged Skin." Journal of the American Academy of Dermatology, vol. 81, no. 2, 2019, pp. 480-488.

Sachs DL, Varani J, Chubb H, et al. Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin. J Am Acad Dermatol. 2019;81(2):480-488.

Sachs, D. L., Varani, J., Chubb, H., Fligiel, S. E. G., Cui, Y., Calderone, K., Helfrich, Y., Fisher, G. J., & Voorhees, J. J. (2019). Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin. Journal of the American Academy of Dermatology, 81(2), 480-488. https://doi.org/10.1016/j.jaad.2019.03.081

Sachs DL, et al. Atrophic and Hypertrophic Photoaging: Clinical, Histologic, and Molecular Features of 2 Distinct Phenotypes of Photoaged Skin. J Am Acad Dermatol. 2019;81(2):480-488. PubMed PMID: 30954583.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin. AU - Sachs,Dana L, AU - Varani,James, AU - Chubb,Heather, AU - Fligiel,Suzanne E G, AU - Cui,Yilei, AU - Calderone,Ken, AU - Helfrich,Yolanda, AU - Fisher,Gary J, AU - Voorhees,John J, Y1 - 2019/04/05/ PY - 2018/08/03/received PY - 2019/01/17/revised PY - 2019/03/08/accepted PY - 2019/4/8/pubmed PY - 2019/12/21/medline PY - 2019/4/8/entrez KW - aging KW - elastosis KW - photoaging KW - skin cancer KW - telangiectasia KW - wrinkles SP - 480 EP - 488 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 81 IS - 2 N2 - BACKGROUND: Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, and in another form, skin appears thickened with coarse wrinkles. Etiologic, clinical, and therapeutic distinctions among different forms of photoaging remain largely unknown. OBJECTIVE: To characterize the clinical, histologic, and molecular features of hypertrophic and atrophic photoaging. METHODS: In total, 53 individuals were clinically classified as having primarily atrophic or hypertrophic photoaging or neither (controls). Participants' demographic and sun exposure-related lifestyle data were captured by questionnaire. Fifteen clinical features of participants were qualitatively or quantitively scored. Facial biopsies were analyzed for gene expression and histologic characteristics. RESULTS: Actinic and seborrheic keratosis, telangiectasia, and prior incidence of skin cancers were statistically significantly greater and photoaging scale severity, coarse wrinkles, thickness, and sallowness were significantly reduced in atrophic versus hypertrophic groups. Histology also revealed significantly less elastotic material in atrophic photoaging. Gene expression of matrix metalloproteinases and collagens did not differ between the 2 forms of photoaging. LIMITATIONS: The study was not designed to identify other possible subtypes of photoaging. CONCLUSION: Systematic, categorical, and quantitative clinical and histologic assessments distinguish atrophic and hypertrophic photoaging. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/30954583/Atrophic_and_hypertrophic_photoaging:_Clinical_histologic_and_molecular_features_of_2_distinct_phenotypes_of_photoaged_skin_ DB - PRIME DP - Unbound Medicine ER -