Tags

Type your tag names separated by a space and hit enter

Vegetarians have a lower fasting insulin level and higher insulin sensitivity than matched omnivores: A cross-sectional study.
Nutr Metab Cardiovasc Dis 2019; 29(5):467-473NM

Abstract

BACKGROUND AND AIMS

Potential associations of vegetarian diet patterns with fasting insulin (FI) and insulin sensitivity remain unclear. We aimed to investigate whether vegetarian diets were associated with FI and insulin sensitivity in a cross-sectional study in Chinese vegetarians and matched omnivores and then to test whether it is independent of body mass index (BMI).

METHODS AND RESULTS

This study included 279 vegetarians (73 vegans, 206 lacto-ovo-vegetarians) and 279 age- and sex-matched omnivores. Fasting blood glucose (FG) and FI concentrations were measured, and β-cell function (HOMA-β) and insulin resistance index (HOMA-IR) were used to evaluate insulin sensitivity. All blood glucose and insulin sensitivity indices were naturally log-transformed, and multiple-linear regression was used to determine the association between vegetarian diet patterns and insulin sensitivity after adjusting for confounders including BMI, visceral fat area, physical activity, sedentary time, income, alcohol consumption, and daily dietary intakes of macronutrients. Compared to omnivores, both vegan diet [β = -0.25, 95% CI: (-0.38, -0.14)] and lacto-ovo-vegetarian diet [β = -0.10, 95% CI: (-0.18, -0.01)] were negatively associated with HOMA-IR after adjusting for BMI. Vegan diet remained negatively associated with FI [β = -0.16, 95% CI: (-0.30, -0.01)] and HOMA-IR [β = -0.17, 95% CI: (-0.32, -0.03)] after adjusting for all confounders.

CONCLUSION

Vegetarian diet, especially vegan diet, is negatively associated with FI and IR, independent of BMI.

Authors+Show Affiliations

Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN 47405, USA.Department of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China; Department of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: caiw1978@163.com.Department of Nutrition, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China; Department of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: srachel@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30956029

Citation

Cui, X, et al. "Vegetarians Have a Lower Fasting Insulin Level and Higher Insulin Sensitivity Than Matched Omnivores: a Cross-sectional Study." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 29, no. 5, 2019, pp. 467-473.
Cui X, Wang B, Wu Y, et al. Vegetarians have a lower fasting insulin level and higher insulin sensitivity than matched omnivores: A cross-sectional study. Nutr Metab Cardiovasc Dis. 2019;29(5):467-473.
Cui, X., Wang, B., Wu, Y., Xie, L., Xun, P., Tang, Q., ... Shen, X. (2019). Vegetarians have a lower fasting insulin level and higher insulin sensitivity than matched omnivores: A cross-sectional study. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 29(5), pp. 467-473. doi:10.1016/j.numecd.2019.01.012.
Cui X, et al. Vegetarians Have a Lower Fasting Insulin Level and Higher Insulin Sensitivity Than Matched Omnivores: a Cross-sectional Study. Nutr Metab Cardiovasc Dis. 2019;29(5):467-473. PubMed PMID: 30956029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetarians have a lower fasting insulin level and higher insulin sensitivity than matched omnivores: A cross-sectional study. AU - Cui,X, AU - Wang,B, AU - Wu,Y, AU - Xie,L, AU - Xun,P, AU - Tang,Q, AU - Cai,W, AU - Shen,X, Y1 - 2019/02/02/ PY - 2018/10/21/received PY - 2018/12/29/revised PY - 2019/01/24/accepted PY - 2019/4/9/pubmed PY - 2019/4/9/medline PY - 2019/4/9/entrez KW - BMI KW - Blood glucose KW - Fasting insulin KW - Insulin sensitivity KW - vegetarian SP - 467 EP - 473 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 29 IS - 5 N2 - BACKGROUND AND AIMS: Potential associations of vegetarian diet patterns with fasting insulin (FI) and insulin sensitivity remain unclear. We aimed to investigate whether vegetarian diets were associated with FI and insulin sensitivity in a cross-sectional study in Chinese vegetarians and matched omnivores and then to test whether it is independent of body mass index (BMI). METHODS AND RESULTS: This study included 279 vegetarians (73 vegans, 206 lacto-ovo-vegetarians) and 279 age- and sex-matched omnivores. Fasting blood glucose (FG) and FI concentrations were measured, and β-cell function (HOMA-β) and insulin resistance index (HOMA-IR) were used to evaluate insulin sensitivity. All blood glucose and insulin sensitivity indices were naturally log-transformed, and multiple-linear regression was used to determine the association between vegetarian diet patterns and insulin sensitivity after adjusting for confounders including BMI, visceral fat area, physical activity, sedentary time, income, alcohol consumption, and daily dietary intakes of macronutrients. Compared to omnivores, both vegan diet [β = -0.25, 95% CI: (-0.38, -0.14)] and lacto-ovo-vegetarian diet [β = -0.10, 95% CI: (-0.18, -0.01)] were negatively associated with HOMA-IR after adjusting for BMI. Vegan diet remained negatively associated with FI [β = -0.16, 95% CI: (-0.30, -0.01)] and HOMA-IR [β = -0.17, 95% CI: (-0.32, -0.03)] after adjusting for all confounders. CONCLUSION: Vegetarian diet, especially vegan diet, is negatively associated with FI and IR, independent of BMI. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/30956029/Vegetarians_have_a_lower_fasting_insulin_level_and_higher_insulin_sensitivity_than_matched_omnivores:_A_cross-sectional_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(19)30029-8 DB - PRIME DP - Unbound Medicine ER -