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High incidence of acquiring methicillin-resistant Staphylococcus aureus in Brazilian children with Atopic Dermatitis and associated risk factors.
J Microbiol Immunol Infect. 2020 Oct; 53(5):724-730.JM

Abstract

BACKGROUND

Methicillin-resistant Staphylococcus aureus (MRSA) colonization in Atopic Dermatitis (AD) patients can contribute to worsening their clinical condition.

OBJECTIVE

A cohort study was carried out to determine the incidence of MRSA acquisition and its risk factors in AD children.

METHODS

Patients with AD (2 months-14 years old) were followed up for about 1 year at a reference center for AD treatment in Rio de Janeiro, Brazil, from September 2011 to February 2014. Nasal swabs from patients and contacts were collected every 2 months. The SCORAD system assessed the severity of the AD. S. aureus isolates were evaluated to determine the methicillin resistance and the clonal lineages.

RESULTS

Among 117 AD patients, 97 (82.9%) were already colonized with S. aureus and 26 (22.2%) had MRSA at the first evaluation. The incidence of MRSA acquisition in the cohort study was 27.47% (n = 25). The SCORAD assessments were: mild (46.15%), moderate (37.36%) or severe (16.48%). Risk factors were: colonized MRSA contacts (HR = 2.27; 95% CI: 1.16-7.54), use of cyclosporine (HR = 5.84; 95% CI: 1.70-19.98), moderate or severe AD (HR = 3.26; 95% CI: 1.13-9.37). Protective factors were: availability of running water (HR = 0.21; 95% CI: 0.049-0.96) and use of antihistamines (HR = 0.21; 95% IC: 0.64-0.75). MRSA isolates carried the SCCmec type IV and most of them were typed as USA800/ST5.

CONCLUSIONS

The high incidence of MRSA acquisition found among AD patients and the risk factors associated show that an effective surveillance of MRSA colonization in these patients is needed.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Abad ED
Pediatric Dermatology Service, IPPMG - Martagão Gesteira Pediatric Institute - Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
Ferreira DC
Veiga de Almeida University, Faculty of Dentistry, Rio de Janeiro, Brazil; Estácio de Sá University, Faculty of Dentistry, Rio de Janeiro, Brazil. Electronic address: denniscf@gmail.com.
Cavalcante FS
Universidade Federal do Rio de Janeiro - UFRJ, Campus Macaé - Rio de Janeiro, Brazil.
Saintive S
Pediatric Dermatology Service, IPPMG - Martagão Gesteira Pediatric Institute - Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
Goudouris E
Pediatric Allergy Service - IPPMG - Martagão Gesteira Pediatric Institute, Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
Prado EA
Pediatric Allergy Service - IPPMG - Martagão Gesteira Pediatric Institute, Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
Hofer C
Department of Preventive Medicine, Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
Ribeiro M
Service of Medical Genetics, IPPMG - Martagão Gesteira Pediatric Institute, Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, Brazil.
da Silva AMP
Estácio de Sá University, Faculty of Dentistry, Rio de Janeiro, Brazil.
Rosado AS
Instituto de Microbiologia Paulo de Góes- Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro, Brazil.
van Elsas JD
University of Groningen, Faculty of Mathematics and Natural Science, Microbial Ecology - GELIFES, the Netherlands.
Dos Santos KRN
Instituto de Microbiologia Paulo de Góes- Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro, Brazil.

MeSH

AdolescentAnti-Bacterial AgentsBrazilChildChild, PreschoolCohort StudiesCyclosporineDermatitis, AtopicFemaleHistamine AntagonistsHumansIncidenceInfantMaleMethicillin-Resistant Staphylococcus aureusMultivariate AnalysisProspective StudiesProtective FactorsRisk FactorsStaphylococcal Infections

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30956127

Citation

Abad, Eliane D., et al. "High Incidence of Acquiring Methicillin-resistant Staphylococcus Aureus in Brazilian Children With Atopic Dermatitis and Associated Risk Factors." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 53, no. 5, 2020, pp. 724-730.
Abad ED, Ferreira DC, Cavalcante FS, et al. High incidence of acquiring methicillin-resistant Staphylococcus aureus in Brazilian children with Atopic Dermatitis and associated risk factors. J Microbiol Immunol Infect. 2020;53(5):724-730.
Abad, E. D., Ferreira, D. C., Cavalcante, F. S., Saintive, S., Goudouris, E., Prado, E. A., Hofer, C., Ribeiro, M., da Silva, A. M. P., Rosado, A. S., van Elsas, J. D., & Dos Santos, K. R. N. (2020). High incidence of acquiring methicillin-resistant Staphylococcus aureus in Brazilian children with Atopic Dermatitis and associated risk factors. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 53(5), 724-730. https://doi.org/10.1016/j.jmii.2018.12.014
Abad ED, et al. High Incidence of Acquiring Methicillin-resistant Staphylococcus Aureus in Brazilian Children With Atopic Dermatitis and Associated Risk Factors. J Microbiol Immunol Infect. 2020;53(5):724-730. PubMed PMID: 30956127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High incidence of acquiring methicillin-resistant Staphylococcus aureus in Brazilian children with Atopic Dermatitis and associated risk factors. AU - Abad,Eliane D, AU - Ferreira,Dennis de Carvalho, AU - Cavalcante,Fernanda S, AU - Saintive,Simone, AU - Goudouris,Ekaterini, AU - Prado,Evandro A, AU - Hofer,Cristina, AU - Ribeiro,Marcia, AU - da Silva,Alexandre Marques Paes, AU - Rosado,Alexandre S, AU - van Elsas,Jan Dirk, AU - Dos Santos,Katia R N, Y1 - 2019/03/21/ PY - 2017/03/29/received PY - 2018/12/11/revised PY - 2018/12/17/accepted PY - 2019/4/9/pubmed PY - 2021/5/25/medline PY - 2019/4/9/entrez KW - Atopic dermatitis KW - MRSA KW - Risk factors KW - S. aureus SP - 724 EP - 730 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 53 IS - 5 N2 - BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) colonization in Atopic Dermatitis (AD) patients can contribute to worsening their clinical condition. OBJECTIVE: A cohort study was carried out to determine the incidence of MRSA acquisition and its risk factors in AD children. METHODS: Patients with AD (2 months-14 years old) were followed up for about 1 year at a reference center for AD treatment in Rio de Janeiro, Brazil, from September 2011 to February 2014. Nasal swabs from patients and contacts were collected every 2 months. The SCORAD system assessed the severity of the AD. S. aureus isolates were evaluated to determine the methicillin resistance and the clonal lineages. RESULTS: Among 117 AD patients, 97 (82.9%) were already colonized with S. aureus and 26 (22.2%) had MRSA at the first evaluation. The incidence of MRSA acquisition in the cohort study was 27.47% (n = 25). The SCORAD assessments were: mild (46.15%), moderate (37.36%) or severe (16.48%). Risk factors were: colonized MRSA contacts (HR = 2.27; 95% CI: 1.16-7.54), use of cyclosporine (HR = 5.84; 95% CI: 1.70-19.98), moderate or severe AD (HR = 3.26; 95% CI: 1.13-9.37). Protective factors were: availability of running water (HR = 0.21; 95% CI: 0.049-0.96) and use of antihistamines (HR = 0.21; 95% IC: 0.64-0.75). MRSA isolates carried the SCCmec type IV and most of them were typed as USA800/ST5. CONCLUSIONS: The high incidence of MRSA acquisition found among AD patients and the risk factors associated show that an effective surveillance of MRSA colonization in these patients is needed. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/30956127/High_incidence_of_acquiring_methicillin_resistant_Staphylococcus_aureus_in_Brazilian_children_with_Atopic_Dermatitis_and_associated_risk_factors_ DB - PRIME DP - Unbound Medicine ER -
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