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The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials.
Eur J Pharmacol. 2019 Jun 05; 852:254-264.EJ

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to evaluate the effect of probiotic and symbiotic supplementation on inflammatory markers among patients with diabetes. Clinical trials were searched using Cochrane Library, EMBASE, PubMed, and Web of Science online databases for relevant trials published until April 2018. Two independent investigators evaluated study eligibility, extracted data, and assessed risk of bias of included clinical trials. Cochran's Q test and I-square (I2) statistic were used to detect heterogeneity among the included. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as the summary effect size. From 986 originally identified publications 18 clinical trials with a total of 1337 patients were included. Findings showed that probiotic and synbiotic supplementation among patients with diabetes significantly decreased tumor necrosis factor-α (TNF-α) (SMD = -2.99; 95% CI, -4.77, -1.20; P = 0.001; I2: 96.3), and C-reactive protein (CRP) (SMD = -0.87; 95% CI, -1.27, -0.48; P < 0.001; I2: 90.2); while significantly increased nitric oxide (NO) concentrations (SMD = 1.49; 95% CI, 0.81, 2.16; P < 0.001; I2: 92.1). There were no effects of probiotic and synbiotic supplementation on interleukin-6 (IL-6) levels (SMD = -0.65; 95% CI, -1.88, 0.59; P = 0.30; I2: 94.7). In summary, the current meta-analysis demonstrated probiotic and synbiotic supplementation among patients with diabetes significantly decreased CRP and TNF-α, and increased NO levels, but did not affect IL-6 levels.

Authors+Show Affiliations

Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran.Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Electronic address: drshokrpour@gmail.com.Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: asemi_r@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30959049

Citation

Tabrizi, Reza, et al. "The Effects of Probiotic and Synbiotic Supplementation On Inflammatory Markers Among Patients With Diabetes: a Systematic Review and Meta-analysis of Randomized Controlled Trials." European Journal of Pharmacology, vol. 852, 2019, pp. 254-264.
Tabrizi R, Ostadmohammadi V, Lankarani KB, et al. The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials. Eur J Pharmacol. 2019;852:254-264.
Tabrizi, R., Ostadmohammadi, V., Lankarani, K. B., Akbari, M., Akbari, H., Vakili, S., Shokrpour, M., Kolahdooz, F., Rouhi, V., & Asemi, Z. (2019). The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials. European Journal of Pharmacology, 852, 254-264. https://doi.org/10.1016/j.ejphar.2019.04.003
Tabrizi R, et al. The Effects of Probiotic and Synbiotic Supplementation On Inflammatory Markers Among Patients With Diabetes: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur J Pharmacol. 2019 Jun 5;852:254-264. PubMed PMID: 30959049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials. AU - Tabrizi,Reza, AU - Ostadmohammadi,Vahidreza, AU - Lankarani,Kamran B, AU - Akbari,Maryam, AU - Akbari,Hamideh, AU - Vakili,Sina, AU - Shokrpour,Maryam, AU - Kolahdooz,Fariba, AU - Rouhi,Vajihe, AU - Asemi,Zatollah, Y1 - 2019/04/06/ PY - 2019/01/18/received PY - 2019/03/28/revised PY - 2019/04/02/accepted PY - 2019/4/9/pubmed PY - 2019/9/4/medline PY - 2019/4/9/entrez KW - Diabetes KW - Inflammatory markers KW - Meta-analysis KW - Probiotic KW - Synbiotic SP - 254 EP - 264 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 852 N2 - This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to evaluate the effect of probiotic and symbiotic supplementation on inflammatory markers among patients with diabetes. Clinical trials were searched using Cochrane Library, EMBASE, PubMed, and Web of Science online databases for relevant trials published until April 2018. Two independent investigators evaluated study eligibility, extracted data, and assessed risk of bias of included clinical trials. Cochran's Q test and I-square (I2) statistic were used to detect heterogeneity among the included. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as the summary effect size. From 986 originally identified publications 18 clinical trials with a total of 1337 patients were included. Findings showed that probiotic and synbiotic supplementation among patients with diabetes significantly decreased tumor necrosis factor-α (TNF-α) (SMD = -2.99; 95% CI, -4.77, -1.20; P = 0.001; I2: 96.3), and C-reactive protein (CRP) (SMD = -0.87; 95% CI, -1.27, -0.48; P < 0.001; I2: 90.2); while significantly increased nitric oxide (NO) concentrations (SMD = 1.49; 95% CI, 0.81, 2.16; P < 0.001; I2: 92.1). There were no effects of probiotic and synbiotic supplementation on interleukin-6 (IL-6) levels (SMD = -0.65; 95% CI, -1.88, 0.59; P = 0.30; I2: 94.7). In summary, the current meta-analysis demonstrated probiotic and synbiotic supplementation among patients with diabetes significantly decreased CRP and TNF-α, and increased NO levels, but did not affect IL-6 levels. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/30959049/The_effects_of_probiotic_and_synbiotic_supplementation_on_inflammatory_markers_among_patients_with_diabetes:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ DB - PRIME DP - Unbound Medicine ER -