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The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study.
Nutrients. 2019 Apr 05; 11(4)N

Abstract

Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45⁻79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43⁻0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association.

Authors+Show Affiliations

Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", 30031 Dolo-Mirano District, Italy. francesco.bolzetta@gmail.com.Aging Branch, Neuroscience Institute, National Research Council, 35128 Padua, Italy. ilmannato@gmail.com. National Institute of Gastroenterlogy, Research Hospital, IRCCS De Bellis, Castellana Grotte, 70013 Bari, Italy. ilmannato@gmail.com.South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK. brendon.stubbs@kcl.ac.uk. Faculty of Health, Social care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, UK. brendon.stubbs@kcl.ac.uk. Institute of Psychiatry, Psychology and Neuroscience (IoPPN) King's College London, De Crespigny Park, London SE5 8AF, UK. brendon.stubbs@kcl.ac.uk.Aging Branch, Neuroscience Institute, National Research Council, 35128 Padua, Italy. marianna.noale@in.cnr.it.Primary Care Department, Azienda ULSS20 Verona, 37122 Verona, Italy. aisamaisa@gmail.com.Primary Care Department, Azienda USL Toscana Sud Est, 58100 Grosseto, Italy. eritrox7@gmail.com.Primary Care Department, Aziendale AAS3 Alto Friuli ⁻ Collinare ⁻ Medio Friuli, 33013 Udine, Italy. celottostefano@gmail.com.University of Siena, 53100 Siena, Italy. chiaracacco@gmail.com.Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", 30031 Dolo-Mirano District, Italy. alberto.cester@aulss3.veneto.it.National Institute of Gastroenterlogy, Research Hospital, IRCCS De Bellis, Castellana Grotte, 70013 Bari, Italy. gabriella.caruso@irccsdebellis.it.National Institute of Gastroenterlogy, Research Hospital, IRCCS De Bellis, Castellana Grotte, 70013 Bari, Italy. rosa.reddavide@irccsdebellis.it.National Institute of Gastroenterlogy, Research Hospital, IRCCS De Bellis, Castellana Grotte, 70013 Bari, Italy. maria.notarnicola@irccsdebellis.it.Aging Branch, Neuroscience Institute, National Research Council, 35128 Padua, Italy. stefania.maggi@in.cnr.it.Research and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, 28029 Barcelona, Spain. koyanagi1117@hotmail.com.New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA. dott.fornaro@gmail.com.NICM Health Research Institute, University of Western Sydney, Penrith, NSW 2751, Australia. joefirth@gmail.com. Division of Psychology and Mental Health, University of Manchester, Manchester M13 9PL, UK. joefirth@gmail.com.The Cambridge Centre for Sport and Exercise Sciences, Department of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK. Lee.Smith@anglia.ac.uk.Department of Neuroscience, University of Padova, 35122 Padova, Italy. marco.solmi83@gmail.com. Padova Neuroscience Center, University of Padova, 35122 Padova, Italy. marco.solmi83@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30959758

Citation

Bolzetta, Francesco, et al. "The Relationship Between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: a Cross-Sectional Analysis From a Large Cohort Study." Nutrients, vol. 11, no. 4, 2019.
Bolzetta F, Veronese N, Stubbs B, et al. The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. Nutrients. 2019;11(4).
Bolzetta, F., Veronese, N., Stubbs, B., Noale, M., Vaona, A., Demurtas, J., Celotto, S., Cacco, C., Cester, A., Caruso, M. G., Reddavide, R., Notarnicola, M., Maggi, S., Koyanagi, A., Fornaro, M., Firth, J., Smith, L., & Solmi, M. (2019). The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. Nutrients, 11(4). https://doi.org/10.3390/nu11040787
Bolzetta F, et al. The Relationship Between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: a Cross-Sectional Analysis From a Large Cohort Study. Nutrients. 2019 Apr 5;11(4) PubMed PMID: 30959758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. AU - Bolzetta,Francesco, AU - Veronese,Nicola, AU - Stubbs,Brendon, AU - Noale,Marianna, AU - Vaona,Alberto, AU - Demurtas,Jacopo, AU - Celotto,Stefano, AU - Cacco,Chiara, AU - Cester,Alberto, AU - Caruso,Maria Gabriella, AU - Reddavide,Rosa, AU - Notarnicola,Maria, AU - Maggi,Stefania, AU - Koyanagi,Ai, AU - Fornaro,Michele, AU - Firth,Joseph, AU - Smith,Lee, AU - Solmi,Marco, Y1 - 2019/04/05/ PY - 2019/01/27/received PY - 2019/03/26/revised PY - 2019/03/29/accepted PY - 2019/4/10/entrez PY - 2019/4/10/pubmed PY - 2019/8/28/medline KW - Osteoarthritis Initiative KW - depression KW - diet KW - mental health KW - nutrition KW - vitamin K JF - Nutrients JO - Nutrients VL - 11 IS - 4 N2 - Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45⁻79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43⁻0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30959758/The_Relationship_between_Dietary_Vitamin_K_and_Depressive_Symptoms_in_Late_Adulthood:_A_Cross_Sectional_Analysis_from_a_Large_Cohort_Study_ L2 - http://www.mdpi.com/resolver?pii=nu11040787 DB - PRIME DP - Unbound Medicine ER -