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Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk.
Curr Vasc Pharmacol. 2019; 17(6):610-617.CV

Abstract

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

Authors+Show Affiliations

Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.IRCCS, SDN, Via Gianturco 113, 80143, Naples, Italy.Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.Department of Geriatric Medicine, University Memory Center, Research Center on Autonomy and Longevity (CeRAL), Angers University Hospital, Angers, France, School of Medicine and UPRES EA 4638, University of Angers, Angers, France.Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.Department of Geriatric Medicine, University Memory Center, Research Center on Autonomy and Longevity (CeRAL), Angers University Hospital, Angers, France, School of Medicine and UPRES EA 4638, University of Angers, Angers, France. Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.Department of Sports Science and Wellness, "Parthenope" University Naples, Naples, Italy.Department of Biochemistry and Molecular Biology, College of Medicine, Al Faisal University, Riyadh, Saudi Arabia.Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.Endocrinology Unit, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Medical School of Naples, Naples, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30963976

Citation

Muscogiuri, Giovanna, et al. "Calcium and Vitamin D Supplementation. Myths and Realities With Regard to Cardiovascular Risk." Current Vascular Pharmacology, vol. 17, no. 6, 2019, pp. 610-617.
Muscogiuri G, Barrea L, Altieri B, et al. Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk. Curr Vasc Pharmacol. 2019;17(6):610-617.
Muscogiuri, G., Barrea, L., Altieri, B., Di Somma, C., Bhattoa, H. P., Laudisio, D., Duval, G. T., Pugliese, G., Annweiler, C., Orio, F., Fakhouri, H., Savastano, S., & Colao, A. (2019). Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk. Current Vascular Pharmacology, 17(6), 610-617. https://doi.org/10.2174/1570161117666190408165805
Muscogiuri G, et al. Calcium and Vitamin D Supplementation. Myths and Realities With Regard to Cardiovascular Risk. Curr Vasc Pharmacol. 2019;17(6):610-617. PubMed PMID: 30963976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk. AU - Muscogiuri,Giovanna, AU - Barrea,Luigi, AU - Altieri,Barbara, AU - Di Somma,Carolina, AU - Bhattoa,Harjit Pal, AU - Laudisio,Daniela, AU - Duval,Guillaume T, AU - Pugliese,Gabriella, AU - Annweiler,Cédric, AU - Orio,Francesco, AU - Fakhouri,Hana, AU - Savastano,Silvia, AU - Colao,Annamaria, PY - 2018/10/06/received PY - 2019/02/09/revised PY - 2019/02/20/accepted PY - 2019/4/10/pubmed PY - 2020/6/9/medline PY - 2019/4/10/entrez KW - Vitamin D KW - bone health KW - calcium KW - cardiovascular system KW - myocardial infarction KW - stroke. SP - 610 EP - 617 JF - Current vascular pharmacology JO - Curr Vasc Pharmacol VL - 17 IS - 6 N2 - Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system. SN - 1875-6212 UR - https://www.unboundmedicine.com/medline/citation/30963976/Calcium_and_Vitamin_D_Supplementation__Myths_and_Realities_with_Regard_to_Cardiovascular_Risk_ L2 - http://www.eurekaselect.com/171454/article DB - PRIME DP - Unbound Medicine ER -