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Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways.
Anticancer Agents Med Chem. 2019; 19(11):1314-1324.AA

Abstract

BACKGROUND

Cancer is a multi-factorial disease including alterations in the cell signalling pathways. Currently, several drugs are in use to treat cancer but such drugs show negative side effects on normal cells and cause severe toxicity.

METHODS

The current research is mainly focused on medicinal plants with potential therapeutic efficacy in the treatment of cancer without any adverse effects on normal cells. In this regard, garlic and its active compounds including diallyl sulfide, diallyl trisulfide, ajoene, and allicin have been established to suppress the growth of cancer and killing of cancer cells.

RESULT

The review focuses on garlic and its active compounds chemopreventive effect through modulating various cell signalling pathways. Additionally, garlic and its active compound were established to induce cell cycle arrest at the G0/G1 phase and G2/M phases in cancer cells, increase the expression of tumor suppressor genes, inhibit the angiogenesis process, induction of apoptosis and modulation of various other genetic pathways.

CONCLUSION

This review sketches the diverse chemopreventive activities of garlic and their active ingredients in the management of cancer mainly focusing on cell signalling pathways.

Authors+Show Affiliations

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30963982

Citation

Almatroodi, Saleh A., et al. "Garlic and Its Active Compounds: a Potential Candidate in the Prevention of Cancer By Modulating Various Cell Signalling Pathways." Anti-cancer Agents in Medicinal Chemistry, vol. 19, no. 11, 2019, pp. 1314-1324.
Almatroodi SA, Alsahli MA, Almatroudi A, et al. Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways. Anticancer Agents Med Chem. 2019;19(11):1314-1324.
Almatroodi, S. A., Alsahli, M. A., Almatroudi, A., & Rahmani, A. H. (2019). Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways. Anti-cancer Agents in Medicinal Chemistry, 19(11), 1314-1324. https://doi.org/10.2174/1871520619666190409100955
Almatroodi SA, et al. Garlic and Its Active Compounds: a Potential Candidate in the Prevention of Cancer By Modulating Various Cell Signalling Pathways. Anticancer Agents Med Chem. 2019;19(11):1314-1324. PubMed PMID: 30963982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways. AU - Almatroodi,Saleh A, AU - Alsahli,Mohammed A, AU - Almatroudi,Ahmad, AU - Rahmani,Arshad H, PY - 2019/01/12/received PY - 2019/03/07/revised PY - 2019/03/15/accepted PY - 2019/4/10/pubmed PY - 2020/4/1/medline PY - 2019/4/10/entrez KW - Garlic KW - allicin KW - angiogenesis KW - apoptosis KW - cell signalling pathways KW - diallyl disulfide KW - diallyl trisulfide. SP - 1314 EP - 1324 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 19 IS - 11 N2 - BACKGROUND: Cancer is a multi-factorial disease including alterations in the cell signalling pathways. Currently, several drugs are in use to treat cancer but such drugs show negative side effects on normal cells and cause severe toxicity. METHODS: The current research is mainly focused on medicinal plants with potential therapeutic efficacy in the treatment of cancer without any adverse effects on normal cells. In this regard, garlic and its active compounds including diallyl sulfide, diallyl trisulfide, ajoene, and allicin have been established to suppress the growth of cancer and killing of cancer cells. RESULT: The review focuses on garlic and its active compounds chemopreventive effect through modulating various cell signalling pathways. Additionally, garlic and its active compound were established to induce cell cycle arrest at the G0/G1 phase and G2/M phases in cancer cells, increase the expression of tumor suppressor genes, inhibit the angiogenesis process, induction of apoptosis and modulation of various other genetic pathways. CONCLUSION: This review sketches the diverse chemopreventive activities of garlic and their active ingredients in the management of cancer mainly focusing on cell signalling pathways. SN - 1875-5992 UR - https://www.unboundmedicine.com/medline/citation/30963982/Garlic_and_its_Active_Compounds:_A_Potential_Candidate_in_The_Prevention_of_Cancer_by_Modulating_Various_Cell_Signalling_Pathways_ L2 - http://www.eurekaselect.com/171456/article DB - PRIME DP - Unbound Medicine ER -