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Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia on Clinical and Economic Outcomes.
Am J Alzheimers Dis Other Demen. 2019 Nov-Dec; 34(7-8):492-499.AJ

Abstract

BACKGROUND

Patients with dementia commonly suffer from symptoms of overactive bladder (OAB); however, limited research exists on the clinical impact of coexisting OAB among patients with dementia. As such, the objective of this study was to examine the impact of OAB on clinical outcomes, health-care resource use, and associated costs among patients with dementia.

METHODS

We conducted a retrospective cohort analysis of patients with dementia using 3861 matched pairs of patients with and without OAB. Analyses were based on administrative claims data from January 1, 2007, to September 30, 2015, and compared clinical outcomes, health services use, and associated costs.

RESULTS

Patients with dementia and OAB were more likely than those without OAB to have least one fall (incidence rate ratio [IRR]: 1.43, 95% confidence interval [CI], 1.22-1.68, P < .001), fracture (IRR: 1.23, 95% CI, 1.05-1.44, P = .008), combined fall/fracture (IRR: 1.25, 95% CI, 1.11-1.42, P < .001), or urinary tract infection (IRR: 2.75, 95% CI, 2.55-2.96, P < .001). Patients with dementia and OAB demonstrated greater utilization of all-cause encounter types compared to similar patients without coexisting OAB (P < .01). All-cause and dementia-related total health-care costs were approximately 23% (95% CI, 0.19-0.28, P < .001) and 13% (95% CI, 0.05-0.20, P = .001), respectively, greater than similar patients without coexisting OAB.

CONCLUSION

Coexisting OAB was associated with impacts on clinical outcomes, health-care resource utilization, and costs in patients with dementia.

Authors+Show Affiliations

Humana Healthcare Research Inc, Louisville, KY, USA.Humana Healthcare Research Inc, Louisville, KY, USA.Humana Healthcare Research Inc, Louisville, KY, USA.Astellas Pharma Global Development, Inc, Northbrook, IL, USA.Astellas Pharma Global Development, Inc, Northbrook, IL, USA.Humana Inc, Cincinnati, OH, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30966757

Citation

Caplan, Eleanor O., et al. "Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia On Clinical and Economic Outcomes." American Journal of Alzheimer's Disease and Other Dementias, vol. 34, no. 7-8, 2019, pp. 492-499.
Caplan EO, Abbass IM, Suehs BT, et al. Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia on Clinical and Economic Outcomes. Am J Alzheimers Dis Other Demen. 2019;34(7-8):492-499.
Caplan, E. O., Abbass, I. M., Suehs, B. T., Ng, D. B., Gooch, K., & van Amerongen, D. (2019). Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia on Clinical and Economic Outcomes. American Journal of Alzheimer's Disease and Other Dementias, 34(7-8), 492-499. https://doi.org/10.1177/1533317519841164
Caplan EO, et al. Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia On Clinical and Economic Outcomes. Am J Alzheimers Dis Other Demen. 2019 Nov-Dec;34(7-8):492-499. PubMed PMID: 30966757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Coexisting Overactive Bladder in Medicare Patients With Dementia on Clinical and Economic Outcomes. AU - Caplan,Eleanor O, AU - Abbass,Ibrahim M, AU - Suehs,Brandon T, AU - Ng,Daniel B, AU - Gooch,Katherine, AU - van Amerongen,Derek, Y1 - 2019/04/09/ PY - 2019/4/11/pubmed PY - 2020/7/11/medline PY - 2019/4/11/entrez KW - costs KW - dementia KW - falls KW - fractures KW - health-care resource utilization KW - overactive bladder SP - 492 EP - 499 JF - American journal of Alzheimer's disease and other dementias JO - Am J Alzheimers Dis Other Demen VL - 34 IS - 7-8 N2 - BACKGROUND: Patients with dementia commonly suffer from symptoms of overactive bladder (OAB); however, limited research exists on the clinical impact of coexisting OAB among patients with dementia. As such, the objective of this study was to examine the impact of OAB on clinical outcomes, health-care resource use, and associated costs among patients with dementia. METHODS: We conducted a retrospective cohort analysis of patients with dementia using 3861 matched pairs of patients with and without OAB. Analyses were based on administrative claims data from January 1, 2007, to September 30, 2015, and compared clinical outcomes, health services use, and associated costs. RESULTS: Patients with dementia and OAB were more likely than those without OAB to have least one fall (incidence rate ratio [IRR]: 1.43, 95% confidence interval [CI], 1.22-1.68, P < .001), fracture (IRR: 1.23, 95% CI, 1.05-1.44, P = .008), combined fall/fracture (IRR: 1.25, 95% CI, 1.11-1.42, P < .001), or urinary tract infection (IRR: 2.75, 95% CI, 2.55-2.96, P < .001). Patients with dementia and OAB demonstrated greater utilization of all-cause encounter types compared to similar patients without coexisting OAB (P < .01). All-cause and dementia-related total health-care costs were approximately 23% (95% CI, 0.19-0.28, P < .001) and 13% (95% CI, 0.05-0.20, P = .001), respectively, greater than similar patients without coexisting OAB. CONCLUSION: Coexisting OAB was associated with impacts on clinical outcomes, health-care resource utilization, and costs in patients with dementia. SN - 1938-2731 UR - https://www.unboundmedicine.com/medline/citation/30966757/Impact_of_Coexisting_Overactive_Bladder_in_Medicare_Patients_With_Dementia_on_Clinical_and_Economic_Outcomes_ L2 - https://journals.sagepub.com/doi/10.1177/1533317519841164?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -