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Deltamethrin-Induced Immunotoxicity and its Protection by Quercetin: An Experimental Study.
Endocr Metab Immune Disord Drug Targets. 2020; 20(1):67-76.EM

Abstract

BACKGROUND

Deltamethrin (DLM) is a type 2 pyrethroid insecticide used in agriculture and home to control pests. However, emerging reports have indicated the immunotoxicity of DLM.

OBJECTIVE

Thus, in the current investigation, we have checked the immune-protective role of quercetin in DLM-induced immunotoxicity by using in silico and in vitro techniques.

RESULTS

In silico results have shown good interaction of quercetin towards immune cell receptors (T & B cell receptors). The findings of in vitro studies indicated the decrease in oxidative stress which is elevated by DLM in concentration & time-dependent manner. The increased caspases-3 activity was decreased by treatment of quercetin. The apoptosis induced by DLM in thymus and spleen was suppressed only at higher concentration (50μg/ml) of quercetin. Finally, the phenotypic changes due to DLM were restored by quercetin.

CONCLUSION

Quercetin has strong binding affinity towards CD4, CD8 and CD28, CD45 receptors and protects the thymocytes and splenocytes against DLM-induced apoptotic signaling pathways.

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Authors+Show Affiliations

Kumar A
Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Lucknow (UP), India.
Gupta M
Department of Pharmacology, ISF College of Pharmacology, Moga, Punjab, India.
Sharma R
Department of Biotechnology, Indo-Soviet Friendship College of Professional Studies (ISFCPS), Moga, Punjab, India.
Sharma N
Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India.

MeSH

AnimalsApoptosisCD28 AntigensCD4 AntigensCD8 AntigensCells, CulturedDose-Response Relationship, DrugInsecticidesLeukocyte Common AntigensLymphocytesMaleMice, Inbred BALB CNitrilesOxidative StressPyrethrinsQuercetinSpleenThymus GlandTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30968779

Citation

Kumar, Anoop, et al. "Deltamethrin-Induced Immunotoxicity and Its Protection By Quercetin: an Experimental Study." Endocrine, Metabolic & Immune Disorders Drug Targets, vol. 20, no. 1, 2020, pp. 67-76.
Kumar A, Gupta M, Sharma R, et al. Deltamethrin-Induced Immunotoxicity and its Protection by Quercetin: An Experimental Study. Endocr Metab Immune Disord Drug Targets. 2020;20(1):67-76.
Kumar, A., Gupta, M., Sharma, R., & Sharma, N. (2020). Deltamethrin-Induced Immunotoxicity and its Protection by Quercetin: An Experimental Study. Endocrine, Metabolic & Immune Disorders Drug Targets, 20(1), 67-76. https://doi.org/10.2174/1871530319666190410144540
Kumar A, et al. Deltamethrin-Induced Immunotoxicity and Its Protection By Quercetin: an Experimental Study. Endocr Metab Immune Disord Drug Targets. 2020;20(1):67-76. PubMed PMID: 30968779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deltamethrin-Induced Immunotoxicity and its Protection by Quercetin: An Experimental Study. AU - Kumar,Anoop, AU - Gupta,Meenakshi, AU - Sharma,Ruchika, AU - Sharma,Neelima, PY - 2018/12/10/received PY - 2019/03/01/revised PY - 2019/03/14/accepted PY - 2019/4/11/pubmed PY - 2020/11/25/medline PY - 2019/4/11/entrez KW - Pyrethroid insecticide KW - apoptosis KW - deltamethrin KW - oxidative stress KW - phenotyping KW - quercetin. SP - 67 EP - 76 JF - Endocrine, metabolic & immune disorders drug targets JO - Endocr Metab Immune Disord Drug Targets VL - 20 IS - 1 N2 - BACKGROUND: Deltamethrin (DLM) is a type 2 pyrethroid insecticide used in agriculture and home to control pests. However, emerging reports have indicated the immunotoxicity of DLM. OBJECTIVE: Thus, in the current investigation, we have checked the immune-protective role of quercetin in DLM-induced immunotoxicity by using in silico and in vitro techniques. RESULTS: In silico results have shown good interaction of quercetin towards immune cell receptors (T & B cell receptors). The findings of in vitro studies indicated the decrease in oxidative stress which is elevated by DLM in concentration & time-dependent manner. The increased caspases-3 activity was decreased by treatment of quercetin. The apoptosis induced by DLM in thymus and spleen was suppressed only at higher concentration (50μg/ml) of quercetin. Finally, the phenotypic changes due to DLM were restored by quercetin. CONCLUSION: Quercetin has strong binding affinity towards CD4, CD8 and CD28, CD45 receptors and protects the thymocytes and splenocytes against DLM-induced apoptotic signaling pathways. SN - 2212-3873 UR - https://www.unboundmedicine.com/medline/citation/30968779/Deltamethrin_Induced_Immunotoxicity_and_its_Protection_by_Quercetin:_An_Experimental_Study_ L2 - http://www.eurekaselect.com/171513/article DB - PRIME DP - Unbound Medicine ER -