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Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman.
BMC Neurol 2019; 19(1):58BN

Abstract

BACKGROUND

Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populations have shown that NMOSDs disproportionately affect black people with relatively more frequent encephalic involvement. We report a case of APS revealing an NMOSD associated with central nervous system (CNS) tuberculosis in a young Togolese woman residing in Togo (West Africa).

CASE PRESENTATION

A 28-year-old Togolese woman was admitted for left hemibody sensory problems with ataxia. These problems were observed while the patient was hospitalized for a few days in the hepato-gastroenterology department for persistent vomiting, abdominal pain and hiccups lasting for about a month. The examination confirmed left hemibody ataxia with nystagmus when looking to the left, pronounced left osteotendinous reflexes, and left hemibody hypoesthesia up to the base of the neck. Encephalic magnetic resonance imaging (MRI) showed a hypersignal lesion in the bulbar more lateralized on the left in the fluid-attenuated inversion recovery sequence, not enhanced after a gadolinium injection. Biological assessment showed the presence of Mycobacterium tuberculosis deoxyribonucleic acid in the cerebrospinal fluid and a sedimentation rate of 120 mm in the 1st hour. The result of the anti-AQP4 antibody test was positive. Two months from the onset of digestive problems with Lhermitte's sign and hand and foot contracture access without vesico-sphincter problems were established. Cervical medullary MRI showed an additional intramedullary hypersignal lesion in the T2 sequence at the C2 level, not enhanced after a gadolinium injection. A second course of intravenous corticosteroids was administered, and anti-tuberculosis treatment was continued. The outcome was favorable. After 8 months of anti-tuberculosis treatment, the patient started immunosuppressive therapy (azathioprine 50 mg twice daily) to limit the risk of recurrence of NMOSD.

CONCLUSION

The recognition of an APS is an additional challenge for the diagnosis of NMOSDs, especially in countries with limited resources. CNS tuberculosis must be tested when faced with an NMOSD because it seems to be a major cause.

Authors+Show Affiliations

Faculte des Sciences de la Sante, Universite de Lome, BP 1515, Lome, Togo. kapetse@univ-lome.tg. Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo. kapetse@univ-lome.tg.Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.Service d'imagerie médicale, CHU Sylvanus Olympio, BP 18, Lome, Togo.Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.Faculte des Sciences de la Sante, Universite de Lome, BP 1515, Lome, Togo. Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.Faculte des Sciences de la Sante, Universite de Lome, BP 1515, Lome, Togo. Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.Faculte des Sciences de la Sante, Universite de Lome, BP 1515, Lome, Togo. Service de Neurologie, CHU CAMPUS de Lome, 03 BP 30284, Lome, Togo.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30971218

Citation

Apetse, Kossivi, et al. "Case Report: an Area Postrema Syndrome Revealing a Neuromyelitis Optica Spectrum Disorder Associated With Central Nervous System Tuberculosis in a Young Togolese (black African) Woman." BMC Neurology, vol. 19, no. 1, 2019, p. 58.
Apetse K, Diatewa JE, Dongmo Tajeuna JJ, et al. Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. BMC Neurol. 2019;19(1):58.
Apetse, K., Diatewa, J. E., Dongmo Tajeuna, J. J., Dansou, Y. M., Bakoudissa, R., Waklatsi, K. P., ... Balogou, A. A. K. (2019). Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. BMC Neurology, 19(1), p. 58. doi:10.1186/s12883-019-1287-5.
Apetse K, et al. Case Report: an Area Postrema Syndrome Revealing a Neuromyelitis Optica Spectrum Disorder Associated With Central Nervous System Tuberculosis in a Young Togolese (black African) Woman. BMC Neurol. 2019 Apr 10;19(1):58. PubMed PMID: 30971218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. AU - Apetse,Kossivi, AU - Diatewa,Josué Euberma, AU - Dongmo Tajeuna,Jean Joel, AU - Dansou,Yaovi Mawuéna, AU - Bakoudissa,Rolph, AU - Waklatsi,Kokouvi Panabalo, AU - Kombate,Damelan, AU - Assogba,Komi, AU - Balogou,Agnon A Koffi, Y1 - 2019/04/10/ PY - 2018/08/10/received PY - 2019/03/28/accepted PY - 2019/4/12/entrez PY - 2019/4/12/pubmed PY - 2019/5/22/medline KW - Africa KW - Area postrema syndrome KW - Neuromyelitis optica spectrum disorders KW - Togo KW - Tuberculosis SP - 58 EP - 58 JF - BMC neurology JO - BMC Neurol VL - 19 IS - 1 N2 - BACKGROUND: Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populations have shown that NMOSDs disproportionately affect black people with relatively more frequent encephalic involvement. We report a case of APS revealing an NMOSD associated with central nervous system (CNS) tuberculosis in a young Togolese woman residing in Togo (West Africa). CASE PRESENTATION: A 28-year-old Togolese woman was admitted for left hemibody sensory problems with ataxia. These problems were observed while the patient was hospitalized for a few days in the hepato-gastroenterology department for persistent vomiting, abdominal pain and hiccups lasting for about a month. The examination confirmed left hemibody ataxia with nystagmus when looking to the left, pronounced left osteotendinous reflexes, and left hemibody hypoesthesia up to the base of the neck. Encephalic magnetic resonance imaging (MRI) showed a hypersignal lesion in the bulbar more lateralized on the left in the fluid-attenuated inversion recovery sequence, not enhanced after a gadolinium injection. Biological assessment showed the presence of Mycobacterium tuberculosis deoxyribonucleic acid in the cerebrospinal fluid and a sedimentation rate of 120 mm in the 1st hour. The result of the anti-AQP4 antibody test was positive. Two months from the onset of digestive problems with Lhermitte's sign and hand and foot contracture access without vesico-sphincter problems were established. Cervical medullary MRI showed an additional intramedullary hypersignal lesion in the T2 sequence at the C2 level, not enhanced after a gadolinium injection. A second course of intravenous corticosteroids was administered, and anti-tuberculosis treatment was continued. The outcome was favorable. After 8 months of anti-tuberculosis treatment, the patient started immunosuppressive therapy (azathioprine 50 mg twice daily) to limit the risk of recurrence of NMOSD. CONCLUSION: The recognition of an APS is an additional challenge for the diagnosis of NMOSDs, especially in countries with limited resources. CNS tuberculosis must be tested when faced with an NMOSD because it seems to be a major cause. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/30971218/Case_report:_an_area_postrema_syndrome_revealing_a_neuromyelitis_optica_spectrum_disorder_associated_with_central_nervous_system_tuberculosis_in_a_young_Togolese_(black_African)_woman L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1287-5 DB - PRIME DP - Unbound Medicine ER -