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Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China.
Ren Fail. 2019 Nov; 41(1):197-203.RF

Abstract

OBJECTIVE

To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference.

METHODS

A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2. We examined the association between SUA levels and CKD. Multivariate binary logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) by comparing association between the SUA level and CKD. The models were adjusted for age, gender, body mass index (BMI), hypertension, diabetes, triglyceride and high-density lipoprotein cholesterol (HDL-C).

RESULT

The prevalence of hyperuricemia was 22.2%, and it was significantly higher in male than in female (25.2% vs. 17%, p < .001). The prevalence of hyperuricemia increased with age, especially in the female. The prevalence of CKD was 27.8% in male and 20.2% in female (p < .001). Compared with the SUA first quartile, the multivariate-adjusted odds for CKD of fourth quartiles were 6.05 (95%CI: 4.32-8.49) in male and 8.21(95%CI: 5.37-12.54) in female.

CONCLUSION

Our finding showed gender-specific differences in the association between high SUA and an increased risk of CKD in the elderly population. The association of SUA and CKD was independent of other potential confounding factors including age, glucose, hypertension, HDL, TG and BMI.

Authors+Show Affiliations

a Department of Nephrology , Affiliated Yijishan Hospital, Wannan Medical College , Wuhu , China.b NanRui Community Health Service Centers , Wuhu , China.a Department of Nephrology , Affiliated Yijishan Hospital, Wannan Medical College , Wuhu , China.a Department of Nephrology , Affiliated Yijishan Hospital, Wannan Medical College , Wuhu , China.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30973288

Citation

Yang, Yanlang, et al. "Gender-specific Association Between Uric Acid Level and Chronic Kidney Disease in the Elderly Health Checkup Population in China." Renal Failure, vol. 41, no. 1, 2019, pp. 197-203.
Yang Y, Zhou W, Wang Y, et al. Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China. Ren Fail. 2019;41(1):197-203.
Yang, Y., Zhou, W., Wang, Y., & Zhou, R. (2019). Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China. Renal Failure, 41(1), 197-203. https://doi.org/10.1080/0886022X.2019.1591994
Yang Y, et al. Gender-specific Association Between Uric Acid Level and Chronic Kidney Disease in the Elderly Health Checkup Population in China. Ren Fail. 2019;41(1):197-203. PubMed PMID: 30973288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender-specific association between uric acid level and chronic kidney disease in the elderly health checkup population in China. AU - Yang,Yanlang, AU - Zhou,Wei, AU - Wang,YuWei, AU - Zhou,Ru, PY - 2019/4/12/entrez PY - 2019/4/12/pubmed PY - 2019/6/7/medline KW - Hyperuricemia KW - chronic kidney disease KW - elderly KW - gender SP - 197 EP - 203 JF - Renal failure JO - Ren Fail VL - 41 IS - 1 N2 - OBJECTIVE: To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore the gender difference. METHODS: A total of 4242 subjects were included in the cross-sectional study. All of the subjects participated in the annual checkup between June 2016 and June 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2. We examined the association between SUA levels and CKD. Multivariate binary logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) by comparing association between the SUA level and CKD. The models were adjusted for age, gender, body mass index (BMI), hypertension, diabetes, triglyceride and high-density lipoprotein cholesterol (HDL-C). RESULT: The prevalence of hyperuricemia was 22.2%, and it was significantly higher in male than in female (25.2% vs. 17%, p < .001). The prevalence of hyperuricemia increased with age, especially in the female. The prevalence of CKD was 27.8% in male and 20.2% in female (p < .001). Compared with the SUA first quartile, the multivariate-adjusted odds for CKD of fourth quartiles were 6.05 (95%CI: 4.32-8.49) in male and 8.21(95%CI: 5.37-12.54) in female. CONCLUSION: Our finding showed gender-specific differences in the association between high SUA and an increased risk of CKD in the elderly population. The association of SUA and CKD was independent of other potential confounding factors including age, glucose, hypertension, HDL, TG and BMI. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/30973288/Gender_specific_association_between_uric_acid_level_and_chronic_kidney_disease_in_the_elderly_health_checkup_population_in_China_ L2 - https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1591994 DB - PRIME DP - Unbound Medicine ER -