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Blood coagulation dynamic testing sensor based on electromagnetic vibration.
Proc Inst Mech Eng H 2019; 233(6):611-620PI

Abstract

Rapid detection techniques and methods of blood coagulation have attracted wide attention in academia and the business community in the presence of the increased demands for rapid assessment (point-of-care testing) of patients from surgery, intensive care unit, and other departments. The differential equation of vibration system composed of elastic support and electromagnetic induction devices was set up using the principle of damping vibration and establishing the dynamics model; meanwhile, the harmonic response analysis and vibration fatigue coupling analysis were carried out, the analysis results were optimized, and the experimental device of the electromagnetic induction testing sensor was established. In addition, the experimental device with blood coagulation reagent was assorted to establish the standard point-of-care testing rapid blood coagulation detection curve, and to compare the testing curve with that of the imported point-of-care testing blood coagulation instrument. The results showed that the first-order natural frequency of the designed sensor was 102.35 Hz, the correlation between the designed sensor and the imported equipment was 0.996, and the testing repeatability of the designed sensor could reach 0.002. Therefore, the designed blood coagulation testing sensor based on electromagnetic induction had the characteristics of favorable elasticity and anti-fatigue, which could meet the accuracy requirements of clinical detection. Taken together, this study could provide the core technology for developing the point-of-care testing instrument for blood coagulation dynamic testing.

Authors+Show Affiliations

1 Changchun University of Science and Technology, Changchun, China.1 Changchun University of Science and Technology, Changchun, China. 2 Key Laboratory of Optical Control and Optical Information Transmission Technology, Department of Education, Changchun, China.1 Changchun University of Science and Technology, Changchun, China. 3 Precision Manufacturing and Testing Technology National Local Joint Engineering Laboratory, Changchun, China.1 Changchun University of Science and Technology, Changchun, China. 4 Key Laboratory of Biological Detection Engineering, Changchun, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30977434

Citation

Wang, Zhe, et al. "Blood Coagulation Dynamic Testing Sensor Based On Electromagnetic Vibration." Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, vol. 233, no. 6, 2019, pp. 611-620.
Wang Z, Yu YH, Yu ZJ, et al. Blood coagulation dynamic testing sensor based on electromagnetic vibration. Proc Inst Mech Eng H. 2019;233(6):611-620.
Wang, Z., Yu, Y. H., Yu, Z. J., & Chen, Q. M. (2019). Blood coagulation dynamic testing sensor based on electromagnetic vibration. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, 233(6), pp. 611-620. doi:10.1177/0954411919837308.
Wang Z, et al. Blood Coagulation Dynamic Testing Sensor Based On Electromagnetic Vibration. Proc Inst Mech Eng H. 2019;233(6):611-620. PubMed PMID: 30977434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood coagulation dynamic testing sensor based on electromagnetic vibration. AU - Wang,Zhe, AU - Yu,Yuan-Hua, AU - Yu,Zhan-Jiang, AU - Chen,Qi-Meng, Y1 - 2019/04/12/ PY - 2019/4/13/pubmed PY - 2019/6/21/medline PY - 2019/4/13/entrez KW - Sensor KW - blood coagulation dynamic testing KW - dynamics modeling KW - elastic support KW - electromagnetic vibration SP - 611 EP - 620 JF - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine JO - Proc Inst Mech Eng H VL - 233 IS - 6 N2 - Rapid detection techniques and methods of blood coagulation have attracted wide attention in academia and the business community in the presence of the increased demands for rapid assessment (point-of-care testing) of patients from surgery, intensive care unit, and other departments. The differential equation of vibration system composed of elastic support and electromagnetic induction devices was set up using the principle of damping vibration and establishing the dynamics model; meanwhile, the harmonic response analysis and vibration fatigue coupling analysis were carried out, the analysis results were optimized, and the experimental device of the electromagnetic induction testing sensor was established. In addition, the experimental device with blood coagulation reagent was assorted to establish the standard point-of-care testing rapid blood coagulation detection curve, and to compare the testing curve with that of the imported point-of-care testing blood coagulation instrument. The results showed that the first-order natural frequency of the designed sensor was 102.35 Hz, the correlation between the designed sensor and the imported equipment was 0.996, and the testing repeatability of the designed sensor could reach 0.002. Therefore, the designed blood coagulation testing sensor based on electromagnetic induction had the characteristics of favorable elasticity and anti-fatigue, which could meet the accuracy requirements of clinical detection. Taken together, this study could provide the core technology for developing the point-of-care testing instrument for blood coagulation dynamic testing. SN - 2041-3033 UR - https://www.unboundmedicine.com/medline/citation/30977434/Blood_coagulation_dynamic_testing_sensor_based_on_electromagnetic_vibration L2 - http://journals.sagepub.com/doi/full/10.1177/0954411919837308?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -